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Unlike traditional treatments such as erythropoiesis\u2010stimulating agents (ESAs), HIF\u2010PH inhibitors are orally administered drugs and may increase endogenous erythropoietin and improve iron homeostasis. However, a significant concern is their possible side effect on blood pressure. The current mini\u2010review summarizes the data of 26 randomized controlled (placebo or ESAs) trials on six different HIF\u2010PH inhibitors with regard to their potential influence on blood pressure and hypertension in the management of anemia in CKD. Overall, the use of HIF\u2010PH inhibitors was associated with a higher risk of hypertension than placebo (pooled risk ratio 1.36, 95% confidence interval [CI] 1.16\u20131.59), but a lower risk of hypertension than ESA treatment (pooled risk ratio 0.92, 95% CI 0.86\u20130.98), especially in CKD patients not undergoing dialysis (pooled risk ratio 0.85, 95% CI 0.73\u20130.98). This review highlights the importance of blood pressure monitoring during the treatment of HIF\u2010PH inhibitors, especially out\u2010of\u2010office blood pressure measurement.<\/jats:p>","DOI":"10.1111\/jch.14924","type":"journal-article","created":{"date-parts":[[2024,11,4]],"date-time":"2024-11-04T12:29:28Z","timestamp":1730723368000},"page":"1375-1383","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Hypertension Induced by Hypoxia\u2010Inducible Factor Prolyl Hydroxylase Inhibitors in Treating Anemia in Patients With Chronic Kidney Disease: A Mini\u2010Review"],"prefix":"10.1111","volume":"26","author":[{"given":"Wei","family":"Zhang","sequence":"first","affiliation":[{"name":"Department of Cardiovascular Medicine, State Key Laboratory of Medical Genomics, Shanghai Key Laboratory of Hypertension, Shanghai Institute of Hypertension Ruijin Hospital, Shanghai Jiao Tong University School of Medicine  Shanghai 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