{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,16]],"date-time":"2026-06-16T20:28:03Z","timestamp":1781641683680,"version":"3.54.5"},"reference-count":19,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2024,11,20]],"date-time":"2024-11-20T00:00:00Z","timestamp":1732060800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Clinical Hypertension"],"published-print":{"date-parts":[[2024,12]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p>This analysis of real\u2010world data examines the efficacy, safety, and long\u2010term outcomes of renal denervation in hypertensive patients for up to 10 years. Sixty\u2010five consecutive patients underwent renal denervation (RDN) (single operator) for uncontrolled resistant hypertension. Efficacy was defined as the interindividual change of office (OBPM) and ambulatory blood pressure monitoring (ABPM) at 1, 6, 12 months, 2\u20134 and 5\u201310 years after RDN. Medication changes, renal function, and device generation disparities were analyzed. Of these patients, 42 received RDN with a first\u2010generation device, while 23 underwent the procedure with a second\u2010generation device. Baseline demographics included a predominantly male cohort (57.6%) with an average age of 60.3 years. The mean number of medications at baseline was 4.3. OBPM at baseline was 169.0\/87.4\u00a0mmHg, and ABPM at baseline was 153.4\/88.4\u00a0mmHg. Post\u2010procedure, significant reductions in systolic blood pressure (SBP) were observed in both OBPM and ABPM at 1 month (OBPM 147.9\/82.8\u00a0mmHg; ABPM 141.3\/83.0\u00a0mmHg [SBP, <jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.001]), sustained up to 10 years (OBPM 153.1\/84.3\u00a0mmHg; ABPM 138\/80.1\u00a0mmHg [SBP, <jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.001]). After 1 year around half of patients had a controlled OBPM and 24\u00a0h ABPM &lt;\u00a0135\/85\u00a0mmHg, which was associated with a higher number of ablation spots (31.5\u00b114.8\u00a0vs. 15.5 \u00b1 6.5, <jats:italic>p<\/jats:italic> = 0.002) and occurred more often when treated with a second\u2010generation device (2 [12.5%] vs. 7 [77.8%], <jats:italic>p<\/jats:italic>\u00a0=\u00a00.002). Renal function displayed a minor physiological decline over 5\u201310 years. No major complication occurred. Renal denervation demonstrated sustained significant reductions in systolic OBPM and ABPM up to 10 years post\u2010procedure. Controlled blood pressure at 1 year was associated with a higher number of mean ablated spots and the use of a second\u2010generation device. The procedure exhibited a favorable safety profile, indicating its viability in managing hypertension without significant renal function compromise.<\/jats:p>","DOI":"10.1111\/jch.14931","type":"journal-article","created":{"date-parts":[[2024,11,20]],"date-time":"2024-11-20T16:47:03Z","timestamp":1732121223000},"page":"1521-1527","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Catheter\u2010Based Renal Denervation for Resistant Arterial Hypertension: 10\u2010Year Real\u2010World Follow\u2010Up Data"],"prefix":"10.1111","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7081-4881","authenticated-orcid":false,"given":"Sofie","family":"Brouwers","sequence":"first","affiliation":[{"name":"Department of Cardiology Cardiovascular Center Aalst  Aalst Belgium"},{"name":"Department of Experimental Pharmacology, Faculty of Medicine and Pharmacy Vrije Universiteit Brussel  Brussels 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