{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T23:32:57Z","timestamp":1788391977217,"version":"build-2803163510"},"reference-count":36,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2024,12,4]],"date-time":"2024-12-04T00:00:00Z","timestamp":1733270400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Clinical Hypertension"],"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p>Sacubitril\/valsartan, an angiotensin receptor\u2010neprilysin inhibitor, has demonstrated a superior blood pressure\u2010lowering effect compared with renin\u2010angiotensin system inhibitors in several clinical trials. However, there has been no available evidence on the comparison between sacubitril\/valsartan and calcium channel blockers (CCBs), a well\u2010established class of antihypertensive drugs.<\/jats:p><jats:p>In this open\u2010label, multicenter study, we aimed to demonstrate the efficacy and safety of sacubitril\/valsartan versus amlodipine, one of the most widely used CCBs, after 8 weeks of treatment. A total of 359 Japanese patients with essential hypertension (office systolic blood pressure [SBP] \u2265\u00a0150 to &lt;\u00a0180\u00a0mmHg), aged 18\u201379, were randomly assigned to receive either once\u2010daily sacubitril\/valsartan 200\u00a0mg or once\u2010daily amlodipine 5\u00a0mg in a 1:1 allocation ratio. The primary endpoint was the noninferiority of sacubitril\/valsartan compared with amlodipine in mean change in 24\u2010h SBP from baseline to Week 8, followed by a significance test as a secondary endpoint analysis. The mean change in 24\u2010h SBP in sacubitril\/valsartan was noninferior to that in amlodipine (between\u2010treatment difference \u22120.62\u00a0mmHg [95% confidential interval: \u22123.23 to 1.98; <jats:italic>p<\/jats:italic> = 0.003 for noninferiority; independent <jats:italic>t<\/jats:italic>\u2010test with noninferiority margin 3.0\u00a0mmHg]), with no significant difference observed (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.637). There was no significant difference in the incidence of adverse events (AEs). These results suggested that the blood pressure\u2010lowering effect of sacubitril\/valsartan is comparable to that of amlodipine, with no marked differences in tolerability between the two groups. Sacubitril\/valsartan, a potent antihypertensive drug comparable to amlodipine, is expected to improve blood pressure control in clinical practice.<\/jats:p>","DOI":"10.1111\/jch.14938","type":"journal-article","created":{"date-parts":[[2024,12,5]],"date-time":"2024-12-05T07:29:15Z","timestamp":1733383755000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Efficacy and Safety of Sacubitril\/Valsartan Versus Amlodipine in Japanese Patients With Essential Hypertension: A Randomized, Multicenter, Open\u2010Label, Noninferiority Study (PARASOL Study)"],"prefix":"10.1111","volume":"27","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0107-9315","authenticated-orcid":false,"given":"Koichi","family":"Yamamoto","sequence":"first","affiliation":[{"name":"Department of Geriatric and General Medicine Osaka University Graduate School of Medicine  Osaka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4547-2805","authenticated-orcid":false,"given":"Daisuke","family":"Yarimizu","sequence":"additional","affiliation":[{"name":"Medical Affairs, Novartis Pharma K.K.  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