{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T22:26:10Z","timestamp":1791930370286,"version":"4.3.4"},"reference-count":54,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2024,11,16]],"date-time":"2024-11-16T00:00:00Z","timestamp":1731715200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100002855","name":"Ministry of Science and Technology of the People's Republic of China","doi-asserted-by":"publisher","award":["2021YFC2700700"],"award-info":[{"award-number":["2021YFC2700700"]}],"id":[{"id":"10.13039\/501100002855","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Clinical Hypertension"],"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p>Circulating lipids play a crucial role during pregnancy and may impact various pregnancy\u2010related diseases. This study employed a two\u2010sample Mendelian randomization (MR) framework to investigate the causal relationship between alterations in multidimensional plasma lipid levels and the risk of preeclampsia or eclampsia, offering deeper insight into this association. The inverse variance weighted (IVW) method was utilized as the main analysis. Summary statistics from plasma lipidomics of 7174 Finnish individuals and summary data on preeclampsia\/eclampsia from the FinnGen consortium involving 219 817 European participants were employed. Sensitivity analyses were conducted to evaluate heterogeneity and pleiotropy. The study identified 17 lipid species from a total of 179 lipid species associated with susceptibility to preeclampsia\/eclampsia. Notably, ten species, including six triacylglycerols (TAGs) (50:1, 48:1, 56:4, 49:2, 48:2, 54:3), a diacylglycerol (DAG) (16:1_18:1), and three sphingomyelins (SMs) (d36:1, d34:1, d38:1), were found to increase the risk of preeclampsia\/eclampsia. Conversely, seven species, including five phosphatidylcholines (PCs) (16:1_20:4, O\u201018:1_20:4, 18:1_20:4, 16:0_20:4, 17:0_20:4) and two phosphatidylethanolamines (PEAs) (18:0_20:4, 16:0_20:4), all containing arachidonic acid (ARA) in the sn\u20102 position, were associated with a reduced risk of preeclampsia\/eclampsia (all <jats:italic>p<\/jats:italic> &lt; 0.05). The results of the\u00a0stratified analysis were consistent with these findings. Furthermore, reverse MR analysis indicated that preeclampsia\/eclampsia does not causally affect plasma levels of these lipids. Our findings established a causal relationship between specific plasma lipid species and modulation of preeclampsia\/eclampsia risk, providing improved resolution for risk assessment and potential therapeutic targets in the disease.<\/jats:p>","DOI":"10.1111\/jch.14939","type":"journal-article","created":{"date-parts":[[2024,11,17]],"date-time":"2024-11-17T02:38:23Z","timestamp":1731811103000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Multidimensional Plasma Lipids Affect Preeclampsia\/Eclampsia: A Mendelian Randomization Study"],"prefix":"10.1111","volume":"27","author":[{"ORCID":"https:\/\/orcid.org\/0009-0002-0431-7323","authenticated-orcid":false,"given":"Shaole","family":"Shi","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology The First Affiliated Hospital of Sun Yat\u2010sen University  Guangzhou China"},{"name":"Guangdong Provincial Clinical Research Center for Obstetrical and Gynecological Diseases  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fangyuan","family":"Wu","sequence":"additional","affiliation":[{"name":"Division of Hypertension and Vascular Diseases Department of Cardiology Heart Center The First Affiliated Hospital of Sun Yat\u2010sen University  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shanshan","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology The First Affiliated Hospital of Sun Yat\u2010sen University  Guangzhou China"},{"name":"Guangdong Provincial Clinical Research Center for Obstetrical and Gynecological Diseases  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zilian","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology The First Affiliated Hospital of Sun Yat\u2010sen University  Guangzhou China"},{"name":"Guangdong Provincial Clinical Research Center for Obstetrical and Gynecological Diseases  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yongqiang","family":"Fan","sequence":"additional","affiliation":[{"name":"Department of Cardiology Donguan Songshan Lake Tungwah Hospital  Dongguan China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,11,16]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41572-023-00417-6"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/AOG.0000000000003891"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/joim.13823"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.3390\/biom14060691"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/MOL.0000000000000927"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.atherosclerosis.2018.05.051"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cbpa.2023.102370"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-023-42532-8"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehad736"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.n2233"},{"key":"e_1_2_11_12_1","doi-asserted-by":"crossref","DOI":"10.1136\/bmj-2022-072148","article-title":"A Framework for Assessing Selection and Misclassification Bias in Mendelian Randomisation Studies: An Illustrative Example Between Body Mass Index and Covid\u201019","volume":"381","author":"Clayton G. 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