{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T05:19:22Z","timestamp":1792819162893,"version":"4.5.0"},"reference-count":62,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2024,11,17]],"date-time":"2024-11-17T00:00:00Z","timestamp":1731801600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Clinical Hypertension"],"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Sarcopenia worsens the prognosis in hypertensive patients, leading to complications such as proteinuria, osteoporosis, disability, and cognitive impairment. Early screening and intervention for sarcopenia in these patients may improve outcomes. This cross\u2010sectional study utilized data from 9253 hypertensive patients in the 1999\u20132018 National Health and Nutrition Examination Survey (NHANES). We used logistic and linear regression models, restricted cubic splines (RCS), and subgroup analyses to evaluate the relationship between pan\u2010immune\u2010inflammation value (PIV) and sarcopenia. Patients were divided into quartiles based on PIV levels. After controlling for confounding factors, our study found that those in the highest PIV quartile faced a 36% greater risk of developing sarcopenia compared to those in the lowest quartile (OR\u00a0=\u00a01.36, 95% confidence interval [CI]: 1.04\u20131.77). The RCS analysis indicated a linear increase in sarcopenia risk as PIV levels rose (non\u2010linear\n                    <jats:italic>p<\/jats:italic>\n                    \u00a0=\u00a00.130). Subgroup analysis demonstrated that diabetes synergistically increased sarcopenia risk (\n                    <jats:italic>p<\/jats:italic>\n                    for interaction\u00a0=\u00a00.007). Elevated PIV levels were identified as an independent risk factor for sarcopenia, with diabetes amplifying this risk. These findings highlight the importance of early identification and management of elevated PIV levels to improve outcomes for hypertensive patients at risk of sarcopenia.\n                  <\/jats:p>","DOI":"10.1111\/jch.14944","type":"journal-article","created":{"date-parts":[[2024,11,18]],"date-time":"2024-11-18T02:30:43Z","timestamp":1731897043000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Association between Pan\u2010Immune Inflammation Value and Sarcopenia in Hypertensive Patients, NHANES 1999\u20132018"],"prefix":"10.1111","volume":"27","author":[{"given":"Lu","family":"Long","sequence":"first","affiliation":[{"name":"Department of Cardiology The Second Affiliated Hospital of Chongqing Medical University  Chongqing China"},{"name":"Department of Geriatrics, Chongqing General Hospital Chongqing University  Chongqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bingquan","family":"Xiong","sequence":"additional","affiliation":[{"name":"Department of Cardiology The Second Affiliated Hospital of Chongqing Medical University  Chongqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhidan","family":"Luo","sequence":"additional","affiliation":[{"name":"Department of Geriatrics, Chongqing General Hospital Chongqing University  Chongqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haiyan","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Geriatrics, Chongqing General Hospital Chongqing University  Chongqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5049-1264","authenticated-orcid":false,"given":"Qiang","family":"She","sequence":"additional","affiliation":[{"name":"Department of Cardiology The Second Affiliated Hospital of Chongqing Medical University  Chongqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,11,17]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cjca.2015.07.734"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2016.19043"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(08)60655-8"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcsm.12147"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0195485"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/ijcp.13800"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.7150\/ijms.20286"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bone.2015.04.016"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.2147\/CIA.S257304"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1155\/2018\/9758040"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41569-023-00964-1"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12026-023-09414-z"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00089.2007"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biocel.2013.06.024"},{"key":"e_1_2_12_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tips.2023.11.005"},{"key":"e_1_2_12_17_1","doi-asserted-by":"publisher","DOI":"10.1301\/00296640260085949"},{"issue":"4","key":"e_1_2_12_18_1","first-page":"445","article-title":"Mechanism of the Occurrence of Sarcopenia in the Elderly","volume":"70","author":"Zhou Y. 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