{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T13:12:27Z","timestamp":1791637947968,"version":"4.3.4"},"reference-count":40,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2024,11,25]],"date-time":"2024-11-25T00:00:00Z","timestamp":1732492800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Clinical Hypertension"],"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p>Angiotensin II receptor blockers (ARBs) and calcium channel blockers (CCBs) are commonly prescribed as first\u2010 and second\u2010line treatments for older Japanese patients with hypertension. However, due to age\u2010related decline in renin activity, the effectiveness of ARBs may decrease. This highlights the need for other antihypertensive agents to be used in combination with CCBs to replace ARBs for more effective blood pressure (BP) control. The ESCORT\u2010HT study is a multicenter, randomized, controlled, open\u2010label, parallel\u2010group study with a 4\u2010week run\u2010in period and 12\u2010week treatment period. This study aims to evaluate the efficacy of esaxerenone as a second\u2010line treatment for hypertension and to determine whether its BP\u2010lowering effect is noninferior to that of ARBs in older patients with uncontrolled hypertension on CCB monotherapy. The safety profiles of esaxerenone and ARBs will also be evaluated. Patients will be randomly assigned in a 1:1 ratio to receive either esaxerenone or an ARB. The primary efficacy endpoint will be the change from baseline in morning home systolic BP at the end of the treatment period. The BP\u2010lowering effect of esaxerenone will be considered noninferior to that of ARBs if the upper limit of the two\u2010sided 95% confidence interval (CI) for the difference in systolic BP change between esaxerenone and ARB is &lt;3.8\u00a0mmHg, and will be considered superior if the upper limit of the two\u2010sided 95% CI is &lt;0. The findings may elucidate the possible benefits of earlier use of mineralocorticoid receptor blockers in combination with CCBs in older patients with essential hypertension.<\/jats:p>","DOI":"10.1111\/jch.14947","type":"journal-article","created":{"date-parts":[[2024,11,25]],"date-time":"2024-11-25T11:10:17Z","timestamp":1732533017000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Rationale and Design of a Randomized, Open\u2010Label, Parallel\u2010Group Study of Esaxerenone Versus Angiotensin Receptor Blockers in Older Patients With Uncontrolled Hypertension on Calcium Channel Blocker Monotherapy (ESCORT\u2010HT)"],"prefix":"10.1111","volume":"27","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8251-4480","authenticated-orcid":false,"given":"Kazuomi","family":"Kario","sequence":"first","affiliation":[{"name":"Division of Cardiovascular Medicine Department of Medicine Jichi Medical University School of Medicine  Shimotsuke Tochigi Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomohiro","family":"Katsuya","sequence":"additional","affiliation":[{"name":"Katsuya Clinic  Amagasaki Hyogo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tatsuo","family":"Shimosawa","sequence":"additional","affiliation":[{"name":"Department of Clinical Laboratory School of Medicine International University of Health and Welfare  Narita Chiba Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takashi","family":"Taguchi","sequence":"additional","affiliation":[{"name":"Primary Medical Science Department Medical Affairs Division Daiichi Sankyo Co., Ltd  Chuo\u2010ku Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ayumi","family":"Tanabe","sequence":"additional","affiliation":[{"name":"Data Intelligence Department Daiichi Sankyo Co., Ltd.  Shinagawa\u2010ku Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mitsuru","family":"Ohishi","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine and Hypertension Graduate School of Medical and Dental Sciences Kagoshima University  Kagoshima Kagoshima Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"the ESCORT\u2010HT investigators","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,11,25]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.35772\/ghm.2019.01011"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jjcc.2023.08.006"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2016.01.037"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.116.07201"},{"issue":"133","key":"e_1_2_11_6_1","first-page":"1","article-title":"Hypertension Among Adults in the United States: National Health and Nutrition Examination Survey, 2011\u20132012","author":"Nwankwo T.","year":"2013","journal-title":"NCHS Data Brief"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/hr.2010.162"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41440-022-01087-9"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.118.11203"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41440-019-0284-9"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41440-019-0238-2"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.2165\/00002512-199405050-00007"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/jch.12733"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.HYP.0000067463.13172.EA"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1524-6175.2004.03146.x"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2015.06.015"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13318-022-00760-1"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41440-024-01762-z"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41440\u2010024\u201001887\u20101"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1253\/circj.CJ-17-0109"},{"key":"e_1_2_11_21_1","unstructured":"Esaxerenone (Minnebro) Tablets [Japanese package insert][In Japanese] Daiichi Sankyo Co. 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