{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,21]],"date-time":"2026-05-21T21:33:39Z","timestamp":1779399219788,"version":"3.53.1"},"reference-count":47,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2025,4,6]],"date-time":"2025-04-06T00:00:00Z","timestamp":1743897600000},"content-version":"vor","delay-in-days":5,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004794","name":"Centre National de la Recherche Scientifique","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004794","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Clinical Hypertension"],"published-print":{"date-parts":[[2025,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p>Hypertension is the most common modifiable cardiovascular risk factor. Policosanol exhibits lipid\u2010modifying and beneficial vascular pleiotropic effects. Some previous Cuban trials found that policosanol lowered blood pressure in hypercholesterolemic patients. Similar results were found recently in prehypertensive Asian subjects. The aim of this study was to report the effects of 20\u00a0mg\/day of policosanol on blood pressure in Cuban patients with prehypertension. A double\u2010blind multicenter trial randomized 400 eligible patients into two strata of 200 patients each (prehypertension and Grade 1 hypertension), treated with placebo or 20\u00a0mg\/day of policosanol (100 patients\/group\/stratum) for 12 weeks. The primary outcome was to determine whether policosanol could achieve significant systolic blood pressure (SBP) reductions \u226510\u00a0mmHg versus placebo. Changes in diastolic blood pressure (DBP) and lipid profile were secondary outcomes. Safety indicators and adverse events (AE) were assessed. Statistical analyses were conducted by intention\u2010to\u2010treat (ITT). Here we report the results of the prehypertension stratum (SBP 120\u2013139\u00a0mmHg, DBP 80\u201389\u00a0mmHg). Both groups were similar at randomization. At study completion, policosanol significantly lowered (<jats:italic>p<\/jats:italic> &lt; 0.001) SBP and DBP values versus baseline and placebo. Also, more (<jats:italic>p<\/jats:italic> &lt; 0.0001) policosanol patients (44%) reached SBP reductions \u226510\u00a0mmHg and DBP reductions \u22655\u00a0mmHg versus baseline (44% and 61%, respectively) than placebo patients (7% and 22%, respectively). Policosanol significantly lowered low\u2010density lipoprotein cholesterol (LDL\u2010C) and total cholesterol (TC) and increased low\u2010density lipoprotein cholesterol (HDL\u2010C). Policosanol was well tolerated. Nine patients (4.5%) discontinued the trial, none because of AE. Four patients (3 placebo, 1 policosanol) reported AE. It is concluded that policosanol 20\u00a0mg\/day given for 12 weeks to Cuban patients with prehypertension lowered SBP and DBP and produced beneficial changes in the lipid profile, being well tolerated.<\/jats:p>","DOI":"10.1111\/jch.14948","type":"journal-article","created":{"date-parts":[[2025,4,7]],"date-time":"2025-04-07T05:34:42Z","timestamp":1744004082000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Efficacy and Safety of Policosanol (Sugarcane Wax Alcohols) 20\u00a0mg\/Day in Cuban Prehypertensive Patients: A Randomized, Double\u2010Blind, Multicentre Study"],"prefix":"10.1111","volume":"27","author":[{"given":"Moura","family":"Revueltas","sequence":"first","affiliation":[{"name":"Department of Epidemiology National Institute of Hygiene, Epidemiology and Microbiology  Havana Cuba"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amarilys","family":"Jimenez Chiquet","sequence":"additional","affiliation":[{"name":"Department of Epidemiology National Institute of Hygiene, Epidemiology and Microbiology  Havana Cuba"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yamile","family":"Valdes","sequence":"additional","affiliation":[{"name":"Calixto Garc\u00eda Hospital  Havana Cuba"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8144-4129","authenticated-orcid":false,"given":"Julio C.","family":"Fern\u00e1ndez","sequence":"additional","affiliation":[{"name":"Clinical Trials Unit National Centre for Scientific Research  Havana Cuba"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yenney","family":"Reyes","sequence":"additional","affiliation":[{"name":"Clinical Trials Unit National Centre for Scientific Research  Havana Cuba"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanay","family":"Fern\u00e1ndez","sequence":"additional","affiliation":[{"name":"Clinical Trials Unit National Centre for Scientific Research  Havana Cuba"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Evelyn","family":"Gonz\u00e1lez","sequence":"additional","affiliation":[{"name":"Clinical Trials Unit National Centre for Scientific Research  Havana Cuba"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarahi","family":"Mendoza","sequence":"additional","affiliation":[{"name":"Clinical Trials Unit National Centre for Scientific Research  Havana Cuba"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yohani","family":"P\u00e9rez","sequence":"additional","affiliation":[{"name":"Clinical Trials Unit National Centre for Scientific Research  Havana Cuba"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manuel Delfin","family":"P\u00e9rez","sequence":"additional","affiliation":[{"name":"Hermanos Ameijeiras Hospital  Havana Cuba"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deisy","family":"Navarro","sequence":"additional","affiliation":[{"name":"Institute of Endocrinology  Havana Cuba"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yolanda","family":"Cruz","sequence":"additional","affiliation":[{"name":"Clinical Laboratory, Medical Surgical Research Centre  Havana Cuba"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meilis","family":"Mesa","sequence":"additional","affiliation":[{"name":"Clinical Laboratory, Medical Surgical Research Centre  Havana Cuba"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gladys","family":"Jim\u00e9nez","sequence":"additional","affiliation":[{"name":"Department of Date Management Cuba's National Clinical Trials Coordinating Centre  Havana Cuba"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlos","family":"S\u00e1nchez","sequence":"additional","affiliation":[{"name":"Department of Date Management Cuba's National Clinical Trials Coordinating Centre  Havana Cuba"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"the Family's Doctors of the polyclinical centres of Plaza Municipality","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,4,6]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1803180"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(21)00221-X"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamainternmed.2017.6015"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.120.15026"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/HJH.0000000000003480"},{"key":"e_1_2_10_7_1","doi-asserted-by":"crossref","unstructured":"S.Virani L. 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