{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T01:10:57Z","timestamp":1787015457685,"version":"build-2736575974"},"reference-count":37,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,1,17]],"date-time":"2025-01-17T00:00:00Z","timestamp":1737072000000},"content-version":"vor","delay-in-days":16,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81500190"],"award-info":[{"award-number":["81500190"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100017950","name":"Shanghai Municipal Health Commission","doi-asserted-by":"publisher","award":["20234Y2139)"],"award-info":[{"award-number":["20234Y2139)"]}],"id":[{"id":"10.13039\/100017950","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100018625","name":"Science and Technology Innovation Plan Of Shanghai Science and Technology Commission","doi-asserted-by":"publisher","award":["23015820100"],"award-info":[{"award-number":["23015820100"]}],"id":[{"id":"10.13039\/501100018625","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Clinical Hypertension"],"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    The aim of this study was to explore whether 24\u2010h ambulatory central (aortic) blood pressure (BP) has an advantage over office central aortic BP in screening for hypertension\u2010mediated target organ damage (HMOD). A total of 714 inpatients with primary hypertension and the presence of several cardiovascular risk factors or complications involving clinical HMOD were enrolled. Twenty\u2010four hour central aortic BP was measured by means of a noninvasive automated oscillometric device (Mobil\u2010O\u2010Graph). Office BP was measured with a validated oscillometric Omron device after a 5\u2010min rest in a sitting position. Central aortic pressure waveforms were derived from the radial pressure waveforms with a validated transfer function of the Sphygmocor software, version 8.0 (Atcor Medical, Sydney, Australia). Carotid\u2013femoral pulse wave velocity (cf\u2010PWV) measurement was performed by sequential placement of the transducer on the femoral artery and carotid artery and determining transit time between the two pulses in reference to the R wave of the ECG. cf\u2010PWV was calculated as the measured distance from the suprasternal notch to the femoral artery minus the distance from the suprasternal notch to the carotid artery divided by the pulse transit time. HMOD was defined as the presence of carotid intima\u2013media thickness (IMT) above normal values and\/or carotid plaque, left ventricular hypertrophy (LVH), renal abnormalities as assessed by urine albumin\/creatinine ratio (ACR) above normal values and\/or estimated glomerular filtration rate (eGFR) less than 60\u00a0mL\/min\/1.73\u00a0m\n                    <jats:sup>2<\/jats:sup>\n                    and\/or increased cf\u2010PWV\u00a0&gt;\u00a010\u00a0m\/s. In the study cohort of 714 (age 54.52\u00a0\u00b1\u00a013.24\u00a0years, 74.6% male) patients with primary hypertension, LV mass index (LVMI) was significantly higher in males (\n                    <jats:italic>p<\/jats:italic>\n                    \u00a0&lt;\u00a00.002) and eGFR was significantly lower in males (\n                    <jats:italic>p<\/jats:italic>\n                    \u00a0&lt;\u00a00.001). However, there was no statistical significance between males and females in IMT, ACR, and cfPWV. When accounting for confounding factors (age, sex, BMI, triglycerides, total cholesterol, LDL, glucose, smoking, and heart rate), central systolic (cSBP), diastolic (DBP), and pulse (cPP) pressure obtained with 24\u2010h monitoring was more strongly correlated with LVMI than office measurements. Twenty\u2010four hour cSBP and cPP were more strongly correlated with IMT than those of office monitoring. The 24\u2010h augmentation index (AIx) was more strongly correlated with eGFR than office AIX. Twnety\u2010four hour cSBP and cPP were more strongly correlated with lgACR. Office AIx and cPP were more strongly correlated with c\u2010fPWV than 24\u2010h measurements while cSBP, DBP, and cPP obtained by both methods were equally correlated with c\u2010fPWV. Ambulatory central (aortic) pressure may be more strongly related to HMOD than office CAP which may have an advantage in screening for c\u2010fPWV.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Trial Registration<\/jats:bold>\n                    : Registration number: ChiCTR2000040308\n                  <\/jats:p>","DOI":"10.1111\/jch.14956","type":"journal-article","created":{"date-parts":[[2025,1,17]],"date-time":"2025-01-17T10:32:24Z","timestamp":1737109944000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Comparison of Influence of Office and 24\u2010h Central Aortic Blood Pressure on Target Organ Damage in Hypertension"],"prefix":"10.1111","volume":"27","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2820-565X","authenticated-orcid":false,"given":"Yueliang","family":"Hu","sequence":"first","affiliation":[{"name":"Department of Geriatrics Medical Center on Aging of Shanghai Ruijin Hospital Shanghai Jiaotong University School of Medicine  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Geriatrics Medical Center on Aging of Shanghai Ruijin Hospital Shanghai Jiaotong University School of Medicine  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guili","family":"Chang","sequence":"additional","affiliation":[{"name":"Department of Hypertension Ruijin Hospital Shanghai Jiao Tong University School of Medicine  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yaya","family":"Bai","sequence":"additional","affiliation":[{"name":"Department of Geriatrics Medical Center on Aging of Shanghai Ruijin Hospital Shanghai Jiaotong University School of Medicine  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8311-2010","authenticated-orcid":false,"given":"Alberto","family":"Avolio","sequence":"additional","affiliation":[{"name":"Macquarie Medical School Faculty of Medicine Health and Human Sciences Macquarie University  Sydney Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qian","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Geriatrics Medical Center on Aging of Shanghai Ruijin Hospital Shanghai Jiaotong University School of Medicine  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shenshen","family":"Gao","sequence":"additional","affiliation":[{"name":"Department of Technology Development Ruijin Hospital Shanghai Jiao Tong University School of Medicine  Shanghai China"},{"name":"Clinical Research and Development Center of Shanghai Municipal Hospitals Shanghai Hospital Development Center  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9850-405X","authenticated-orcid":false,"given":"Junli","family":"Zuo","sequence":"additional","affiliation":[{"name":"Department of Geriatrics Medical Center on Aging of Shanghai Ruijin Hospital Shanghai Jiaotong University School of Medicine  Shanghai China"},{"name":"Macquarie Medical School Faculty of Medicine Health and Human Sciences Macquarie University  Sydney Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,1,17]]},"reference":[{"issue":"3","key":"e_1_2_10_2_1","first-page":"182","article-title":"2018 Chinese Guidelines for Prevention and Treatment of Hypertension\u2010A Report of the Revision Committee of Chinese Guidelines for Prevention and Treatment of Hypertension","volume":"16","author":"Joint Committee for Guideline R","year":"2019","journal-title":"Journal of Geriatric Cardiology"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.107.089078"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.115.06066"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehq024"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1093\/ajh\/hpu146"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/eht565"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1097\/HJH.0000000000000969"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11906-016-0681-2"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1097\/HJH.0000000000000263"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/jhh.2014.101"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1097\/HJH.0b013e3283531eaf"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.116.303755"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1097\/HJH.0b013e328363e964"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12889-015-1594-8"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1006\/pmed.2002.1032"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1161\/circ.106.25.3143"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1097\/MBP.0b013e328339be38"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehw632"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1038\/jhh.2010.27"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.111.176313"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1038\/jhh.2010.47"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2261-12-48"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1038\/hr.2012.78"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1038\/ajh.2012.63"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.95.7.1827"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.echo.2015.05.002"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1097\/HJH.0b013e32832cb04e"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.hjh.0000431740.32696.cc"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000160923.04524.5B"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.HYP.0000170138.56903.7a"},{"key":"e_1_2_10_32_1","doi-asserted-by":"publisher","DOI":"10.1097\/HJH.0b013e328350bb40"},{"key":"e_1_2_10_33_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.105.595496"},{"key":"e_1_2_10_34_1","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.117.09917"},{"key":"e_1_2_10_35_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41440-018-0175-5"},{"key":"e_1_2_10_36_1","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.108.525253"},{"key":"e_1_2_10_37_1","doi-asserted-by":"publisher","DOI":"10.1097\/HJH.0b013e32834e12d8"},{"key":"e_1_2_10_38_1","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.110.153924"}],"container-title":["The Journal of Clinical Hypertension"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jch.14956","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,10]],"date-time":"2025-04-10T03:36:27Z","timestamp":1744256187000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jch.14956"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,1]]},"references-count":37,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2025,1]]}},"alternative-id":["10.1111\/jch.14956"],"URL":"https:\/\/doi.org\/10.1111\/jch.14956","archive":["Portico"],"relation":{},"ISSN":["1524-6175","1751-7176"],"issn-type":[{"value":"1524-6175","type":"print"},{"value":"1751-7176","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,1]]},"assertion":[{"value":"2024-04-19","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-11-25","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-01-17","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e14956"}}