{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T00:47:03Z","timestamp":1790988423726,"version":"4.1.0"},"reference-count":28,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,1,17]],"date-time":"2025-01-17T00:00:00Z","timestamp":1737072000000},"content-version":"vor","delay-in-days":16,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Clinical Hypertension"],"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    This study evaluated initial antihypertensive drug prescription patterns in Indian healthcare settings. An observational, cross\u2010sectional, prospective prescription registry analyzed prescriptions for 4723 newly diagnosed hypertension patients. Additionally, it investigated the extent to which physicians adhered to either European or Indian hypertension guidelines. Angiotensin receptor blockers (ARBs) were the most commonly prescribed drugs, given to 79% of patients, followed by calcium channel blockers (CCBs) at 55%. Diuretics and beta\u2010blockers (BBs) were prescribed to 27% and 17% of patients, respectively. Monotherapy was administered to 35% of patients, while combination therapies were more prevalent, with dual therapy at 51% and regimens involving three or more drugs prescribed to 14%. Among multi\u2010drug treatments (\n                    <jats:italic>n<\/jats:italic>\n                    \u00a0=\u00a03082, 65%), 98% received fixed\u2010dose combination tablets. The most common combinations were ARB\u00a0+\u00a0CCB (26%), ARB\u00a0+\u00a0diuretic (12%), and ARB\u00a0+\u00a0CCB\u00a0+\u00a0diuretic (8%). Key predictors for an increasing number of prescribed drugs included statin use\/dyslipidemia, age, blood pressure level, and diabetes. Non\u2010adherence to hypertension guidelines was evident as 1364 patients classified from moderate to very high risk received monotherapy. Of these, 496 patients had grade 2 or 3 hypertension. Additionally, 88 patients received the undesirable combination of ACEi\u00a0+\u00a0ARB, and 267 (15.9%) type 2 diabetes mellitus (T2DM) patients did not receive RAS\u2010blockers (146 on monotherapy). The findings reveal a trend toward utilizing ARBs, CCBs, and combination tablets, indicating improved adherence to guidelines. However, a significant number of patients did not receive appropriate treatment, highlighting areas for improvement in prescription practices.\n                  <\/jats:p>","DOI":"10.1111\/jch.14963","type":"journal-article","created":{"date-parts":[[2025,1,17]],"date-time":"2025-01-17T09:43:47Z","timestamp":1737107027000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Identifying Drug Prescription in Newly Diagnosed Hypertension Patients in India"],"prefix":"10.1111","volume":"27","author":[{"given":"Thomas","family":"Alexander","sequence":"first","affiliation":[{"name":"Department of Interventional Cardiology Kovai Medical Center and Hospital  Coimbatore Tamil Nadu India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jagdish S.","family":"Hiremath","sequence":"additional","affiliation":[{"name":"Department of Interventional Cardiology Ruby Hall Clinic  Pune Maharashtra India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jitendra P. S.","family":"Swahney","sequence":"additional","affiliation":[{"name":"Department of Cardiology Sir Ganga Ram Hospital  New Delhi India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Subhash","family":"Chandra","sequence":"additional","affiliation":[{"name":"Department of Interventional Cardiology \u2013 Cardiology &amp; Structural Heart Disease Blk\u2010Max Super Speciality Hospital  New Delhi India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peeyush","family":"Jain","sequence":"additional","affiliation":[{"name":"Department of Preventive Cardiology Fortis Hospital Delhi  New Delhi India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Praveen","family":"Chandra","sequence":"additional","affiliation":[{"name":"Department of Interventional Cardiology Cardiac Care, Medanta Medicity  Gurgaon India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nakul","family":"Sinha","sequence":"additional","affiliation":[{"name":"Department of Interventional Cardiology Medanta Heart Institute  Lucknow Uttar Pradesh India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T.","family":"Sashikanth","sequence":"additional","affiliation":[{"name":"Department of Interventional Cardiology Yashoda Hospitals  Secunderabad Telangana India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yugandhar","family":"Bachhu","sequence":"additional","affiliation":[{"name":"Department of Interventional Cardiology  Tirupati Andhra Pradesh India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anil","family":"Balachandran","sequence":"additional","affiliation":[{"name":"Department of Interventional Cardiology Lakshmi Hospital  Cochin Kerala India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pathiyil Balagopalan","family":"Jayagopal","sequence":"additional","affiliation":[{"name":"Department of Cardiology Lakshmi Hospital  Palakkad Kerala India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T. Govindan","family":"Unni","sequence":"additional","affiliation":[{"name":"Department of Cardiology Jubilee Mission Medical College &amp; Research Institute  Thrissur Kerala India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tiny","family":"Nair","sequence":"additional","affiliation":[{"name":"Department of Cardiology PRS Hospital, Killipalam  Trivandrum Kerala India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kumaresan","family":"Kannan","sequence":"additional","affiliation":[{"name":"Department of Cardiology Aswene Soundra Hospital and Research Centre  Chennai India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dorairaj","family":"Prabhakar","sequence":"additional","affiliation":[{"name":"Department of Interventional Cardiology Apollo Firstmed Hospital, Consultant Cardiologist, Ashwin Clinic  Chennai India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Chenniappan","sequence":"additional","affiliation":[{"name":"IMA College of General Practitioners  Trichy India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ajay U.","family":"Mahajan","sequence":"additional","affiliation":[{"name":"Department of Cardiology G.S. Medical College &amp; K.E.M Hospital  Mumbai USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rajiv D.","family":"Karnik","sequence":"additional","affiliation":[{"name":"Department of Interventional Cardiology Cath Interventions, Fortis Hospital  Mumbai Maharashtra India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chandrashekhar K.","family":"Ponde","sequence":"additional","affiliation":[{"name":"Department of Cardiology Hinduja Hospital and Medical Research Centre  Mumbai Maharashtra India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Prashant","family":"Advani","sequence":"additional","affiliation":[{"name":"Department of Cardiology Advani Heartline  Raipur Chhattisgarh India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Idris Ahmed","family":"Khan","sequence":"additional","affiliation":[{"name":"Department of Interventional Cardiology Bombay Hospital  Indore Madhya Pradesh India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brij Mohan","family":"Goyal","sequence":"additional","affiliation":[{"name":"Cardiac Science Apex Hospital  Jaipur Rajasthan India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P. R.","family":"Vaidyanathan","sequence":"additional","affiliation":[{"name":"Department of Cardiology Hindusthan Hospital  Coimbatore Tamil Nadu India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiren","family":"Prajapati","sequence":"additional","affiliation":[{"name":"Department of Medical Affairs Eris Lifesciences Ltd.  Ahmedabad Gujarat India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2230-0488","authenticated-orcid":false,"given":"Willem J.","family":"Verberk","sequence":"additional","affiliation":[{"name":"CARIM School for Cardiovascular Diseases Maastricht University  Maastricht The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,1,17]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamanetworkopen.2023.39098"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.118.11558"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjmed.2004.03.035"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40885-021-00183-1"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41371-020-0349-x"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/HJH.0000000000003480"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lansea.2023.100156"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.118.313220"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehy339"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.rcsop.2023.100315"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2213-8587(23)00119-5"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jash.2013.02.006"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0801317"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.3390\/cimb46070377"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.2174\/13816128113199990299"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0806182"},{"key":"e_1_2_11_18_1","first-page":"e13","article-title":"2017 ACC\/AHA\/AAPA\/ABC\/ACPM\/AGS\/APhA\/ASH\/ASPC\/NMA\/PCNA Guideline for the Prevention, Detection, Evaluation, and Management of High Blood Pressure in Adults: A Report of the American College of Cardiology\/American Heart Association Task Force on Clinical Practice Guidelines","volume":"71","author":"Whelton P. K.","year":"2018","journal-title":"Hypertension"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.3109\/10641963.2015.1025959"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/jch.13894"},{"key":"e_1_2_11_21_1","article-title":"Renal Function in Hypertensive Patients Receiving Cilnidipine and L\u2010Type Calcium Channel Blockers: A Meta\u2010Analysis of Randomized Controlled and Retrospective Studies","volume":"14","author":"Srivathsan M.","year":"2022","journal-title":"Cureus"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10557-021-07248-1"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13410-022-01143-7"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacl.2024.01.006"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehz486"},{"key":"e_1_2_11_26_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00125-006-0393-2"},{"key":"e_1_2_11_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ihj.2020.03.015"},{"key":"e_1_2_11_28_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0263619"},{"key":"e_1_2_11_29_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41440-024-01585-y"}],"container-title":["The Journal of Clinical Hypertension"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jch.14963","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,10]],"date-time":"2025-04-10T03:36:37Z","timestamp":1744256197000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jch.14963"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,1]]},"references-count":28,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2025,1]]}},"alternative-id":["10.1111\/jch.14963"],"URL":"https:\/\/doi.org\/10.1111\/jch.14963","archive":["Portico"],"relation":{},"ISSN":["1524-6175","1751-7176"],"issn-type":[{"value":"1524-6175","type":"print"},{"value":"1751-7176","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,1]]},"assertion":[{"value":"2024-08-09","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-12-10","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-01-17","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e14963"}}