{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,8]],"date-time":"2025-11-08T18:09:31Z","timestamp":1762625371726,"version":"3.41.2"},"reference-count":31,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,1,18]],"date-time":"2025-01-18T00:00:00Z","timestamp":1737158400000},"content-version":"vor","delay-in-days":17,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Clinical Hypertension"],"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p>To assess the effectiveness and safety of Sacubitril\/Valsartan in reducing blood pressure in individuals with non\u2010dialysis\u2010dependent chronic kidney disease (NDD\u2010CKD) Stage 3\u20135 complicated by hypertension. This study was a multicenter retrospective analysis conducted from March 1, 2022 to March 31, 2024, involving adult patients with NDD\u2010CKD Stage 3\u20135 and hypertension, who received Sacubitril\/Valsartan either as a monotherapy or in addition to current antihypertensive treatments that were insufficient. The main outcomes measured were blood pressure control, changes in blood pressure and laboratory parameters within 8 weeks post\u2010treatment initiation, and incidence of adverse events. The study included a total of 459 individuals with NDD\u2010CKD Stage 3\u20135 and hypertension. At the study endpoint, mean systolic blood pressure, diastolic blood pressure, and pulse pressure were markedly reduced compared to baseline (all <jats:italic>p<\/jats:italic> &lt; 0.001). The average blood pressure reductions were 12.17 (4.66, 22.00), 6.00 (0.67, 12.66), and 6.67 (0.08, 14.00) mmHg, respectively. Throughout the study period, 96 patients (20.92%) with NDD\u2010CKD Stage 3\u20135 developed worsening renal function, 15 patients (3.27%) developed hyperkalemia, and 49 patients (10.68%) experienced symptomatic hypotension. Overall, there were no significant differences in the changes in serum creatinine, estimated glomerular filtration rate, and serum potassium before and after treatment (<jats:italic>p<\/jats:italic> = 0.28, <jats:italic>p<\/jats:italic> = 0.91, <jats:italic>p<\/jats:italic> = 0.61, respectively). Sacubitril\/Valsartan significantly lowers blood pressure in patients with NDD\u2010CKD Stage 3\u20135 complicated by hypertension, with good safety profiles.<\/jats:p><jats:p>Trial Registration: ClinicalTrials.gov identifier: ChiCTR2400086079<\/jats:p>","DOI":"10.1111\/jch.14969","type":"journal-article","created":{"date-parts":[[2025,1,18]],"date-time":"2025-01-18T17:50:03Z","timestamp":1737222603000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Sacubitril\/Valsartan for Blood Pressure Lowering in Non\u2010Dialysis\u2010Dependent Chronic Kidney Disease Stage 3\u20135 Patients With Hypertension: A Multicenter Clinical Study"],"prefix":"10.1111","volume":"27","author":[{"given":"Yu","family":"Yan","sequence":"first","affiliation":[{"name":"Department of Nephrology Southeast University Zhongda Hospital Southeast University School of Medicine  Nanjing 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