{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,3]],"date-time":"2026-11-03T03:06:04Z","timestamp":1793675164012,"version":"4.5.1"},"reference-count":43,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,1,29]],"date-time":"2025-01-29T00:00:00Z","timestamp":1738108800000},"content-version":"vor","delay-in-days":28,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Clinical Hypertension"],"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p>Vascular compliance is an important predictor of cardiovascular disease and mortality. Pulse pressure index (PPI) is a reliable indicator for evaluating vascular compliance. However, the association between PPI, all\u2010cause mortality (ACM), and cardiovascular mortality (CVM) in patients with hypertension is still unclear. In this study, we aimed to investigate the association of PPI with ACM and CVM in patients with hypertension. Kaplan\u2013Meier survival curves, Cox proportional hazards regression models, restricted cubic splines, and subgroup and interaction analyses were used to investigate the association of PPI with ACM and CVM. U\u2010shaped associations were observed between PPI and both ACM and CVM, and the inflection points for ACM and CVM were at PPI values of 0.327 and 0.363, respectively. Time\u2010dependent receiver operating characteristic curves indicated that PPI showed good predictive value for both ACM and CVM occurrence at 1, 3, 5, and 10\u00a0years, and its predictive value was higher than PP for ACM and CVM at 5 and 10\u00a0years. These results showed that PPI can be used to identify patients with hypertension who are at a high risk of mortality and can guide more aggressive anti\u2010hypertensive treatment strategies. Moreover, these findings demonstrate that PPI is a superior vascular compliance indicator than PP.<\/jats:p>","DOI":"10.1111\/jch.70004","type":"journal-article","created":{"date-parts":[[2025,1,29]],"date-time":"2025-01-29T13:11:24Z","timestamp":1738156284000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Association of Pulse Pressure Index With Mortality in Patients With Hypertension: Results From NHANES 1999\u20132018"],"prefix":"10.1111","volume":"27","author":[{"given":"Hongjin","family":"Jin","sequence":"first","affiliation":[{"name":"Department of Cardiology The Second Hospital of Dalian Medical University  Dalian China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shusheng","family":"Fang","sequence":"additional","affiliation":[{"name":"Department of Critical Care Medicine The Second Hospital of Dalian Medical University  Dalian China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuo","family":"An","sequence":"additional","affiliation":[{"name":"Department of Cardiology The Second Hospital of Dalian Medical University  Dalian China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-9296-8689","authenticated-orcid":false,"given":"Yanchun","family":"Ding","sequence":"additional","affiliation":[{"name":"Department of Cardiology The Second Hospital of Dalian Medical University  Dalian China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,1,29]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(14)61468-9"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(21)01330-1"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(17)30017-X"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.15420\/ecr.2019.11.1"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.122.321762"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2020.04.038"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41440-022-01090-0"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.ajkd.2011.08.015"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1093\/qjmed\/95.2.107"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.100.4.354"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/jch.12375"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.HYP.32.3.560"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mehy.2008.12.041"},{"key":"e_1_2_10_15_1","first-page":"218","article-title":"The Severity of Coronary Artery Disease Evaluated by central Systolic Pressure and Fractional Diastolic Pressure","volume":"2","author":"Song\u2010Tao A.","year":"2010","journal-title":"North American Journal of Medicine and Science"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jstrokecerebrovasdis.2015.02.011"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu15020461"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12933-024-02191-5"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12889-023-17373-1"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.3389\/fcvm.2022.952953"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12933-024-02209-y"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12933-023-01986-2"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12933-023-01998-y"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1097\/CM9.0000000000002753"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12933-024-02172-8"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12933-024-02152-y"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12889-024-18071-2"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcsm.13032"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.118.12289"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2019.07.012"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40885-023-00258-1"},{"key":"e_1_2_10_32_1","doi-asserted-by":"publisher","DOI":"10.1136\/postgradmedj-2019-137070"},{"key":"e_1_2_10_33_1","first-page":"152","article-title":"The Effect of Pulse Pressure on All\u2010Cause and Cardiovascular\u2010Specific Mortality Risks in US Adults","volume":"25","author":"Borrell L. N.","year":"2015","journal-title":"Ethnicity & Disease"},{"key":"e_1_2_10_34_1","doi-asserted-by":"publisher","DOI":"10.1097\/00004872-199917080-00004"},{"key":"e_1_2_10_35_1","first-page":"58","article-title":"AI\/ML to Relationship Between Circadian Rhythm of Blood Pressure and Left Ventricular Hypertrophy in Patients With Hypertension","volume":"30","author":"Ma Q.","year":"2024","journal-title":"Alternative Therapies in Health and Medicine"},{"key":"e_1_2_10_36_1","first-page":"98","article-title":"Significant Correlation Between Brachial Pulse Pressure Index and Renal Resistive Index","volume":"31","author":"Lee M. K.","year":"2015","journal-title":"Acta Cardiological Sinica"},{"key":"e_1_2_10_37_1","first-page":"468","article-title":"Relationship Between Pulse Pressure, Pulse Pressure Index and Prevalence of Stroke Among Rural Population in China","volume":"87","author":"Zhang X.","year":"2007","journal-title":"Zhonghua Yi Xue Za Zhi"},{"key":"e_1_2_10_38_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11906-010-0150-2"},{"key":"e_1_2_10_39_1","doi-asserted-by":"publisher","DOI":"10.7717\/peerj.15797"},{"key":"e_1_2_10_40_1","doi-asserted-by":"publisher","DOI":"10.3109\/10641963.2014.954713"},{"key":"e_1_2_10_41_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.96.1.308"},{"key":"e_1_2_10_42_1","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.113.01940"},{"key":"e_1_2_10_43_1","doi-asserted-by":"publisher","DOI":"10.3389\/fcvm.2021.810105"},{"key":"e_1_2_10_44_1","doi-asserted-by":"publisher","DOI":"10.1177\/00033197221124765"}],"container-title":["The Journal of Clinical Hypertension"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jch.70004","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,10]],"date-time":"2025-04-10T07:37:29Z","timestamp":1744270649000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jch.70004"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,1]]},"references-count":43,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2025,1]]}},"alternative-id":["10.1111\/jch.70004"],"URL":"https:\/\/doi.org\/10.1111\/jch.70004","archive":["Portico"],"relation":{},"ISSN":["1524-6175","1751-7176"],"issn-type":[{"value":"1524-6175","type":"print"},{"value":"1751-7176","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,1]]},"assertion":[{"value":"2024-09-28","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-01-13","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-01-29","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70004"}}