{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,3]],"date-time":"2026-08-03T11:51:55Z","timestamp":1785757915370,"version":"3.56.0"},"reference-count":39,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,1,29]],"date-time":"2025-01-29T00:00:00Z","timestamp":1738108800000},"content-version":"vor","delay-in-days":28,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Clinical Hypertension"],"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p>Hypertensive disorders in pregnancy (HDPs) are a leading cause of poor maternal and birth outcomes worldwide. Prompt management of these disorders is usually recommended to optimize outcomes. Administration of pharmacotherapeutic agents is critical in the prevention and management of these disorders. The services of the pharmacist are required to maximize the benefits of drug therapy during prevention and management. There is a paucity of data on the effectiveness of pharmacist\u2010led interventions in the management of these disorders in Ghana.<\/jats:p><jats:p>This study investigated the effect of a pharmacist\u2010led intervention on knowledge, adherence to antihypertensive medication, and blood pressure (BP) control among pregnant women.<\/jats:p><jats:p>A quasi\u2010experimental study was conducted. The study was carried out among pregnant women with moderate to high risk of developing HDPs and seeking antenatal care at a university hospital in Kumasi, Ghana. The pharmaceutical care model comprising health education, counseling, and medication administration reminders was provided fortnightly to study participants till delivery. Differences in pre\u2010 and post\u2010intervention median scores were compared using the Wilcoxon signed\u2010rank test.<\/jats:p><jats:p>The mean age was 35.7 years (\u00b1 1.2). The overall median knowledge and adherence scores increased significantly after the intervention by 11 versus 17 (<jats:italic>p<\/jats:italic> &lt; 0.001) and 5 versus 9 (<jats:italic>p<\/jats:italic> &lt; 0.001), respectively. Pharmaceutical intervention increased the proportion of mothers who were adherent by 68.9% (95% CI, 53.9\u201383.8%; <jats:italic>p<\/jats:italic> &lt; 0.001). The commonest side effect of the two first\u2010line antihypertensives (nifedipine and methyldopa) was headache. About 91% of the women delivered vaginally, and almost all (97.8%) of all deliveries were live births.<\/jats:p><jats:p>Pharmacist\u2010led interventions had a positive impact on the knowledge of HDPs and adherence to antihypertensive medication in the study setting. Thus, incorporating pharmaceutical care into antenatal care would be worthwhile.<\/jats:p>","DOI":"10.1111\/jch.70005","type":"journal-article","created":{"date-parts":[[2025,1,29]],"date-time":"2025-01-29T13:17:25Z","timestamp":1738156645000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Exploring the Role of the Pharmacist in the Prevention and Management of Hypertensive Disorders in Pregnancy in Ashanti Region, Ghana"],"prefix":"10.1111","volume":"27","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2302-1854","authenticated-orcid":false,"given":"Pauline","family":"Boachie\u2010Ansah","sequence":"first","affiliation":[{"name":"Department of Pharmacy Practice Faculty of Pharmacy and Pharmaceutical Sciences Kwame Nkrumah University of Science and Technology  Kumasi Ghana"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Berko Panyin","family":"Anto","sequence":"additional","affiliation":[{"name":"Department of Pharmacy Practice Faculty of Pharmacy and Pharmaceutical Sciences Kwame Nkrumah University of Science and Technology  Kumasi Ghana"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Afia Frimpomaa Asare","family":"Marfo","sequence":"additional","affiliation":[{"name":"Department of Pharmacy Practice Faculty of Pharmacy and Pharmaceutical Sciences Kwame Nkrumah University of Science and Technology  Kumasi Ghana"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edward Tieru","family":"Dassah","sequence":"additional","affiliation":[{"name":"Department of Population and Family Reproductive Health School of Public Health Kwame Nkrumah University of Science and Technology  Kumasi Ghana"},{"name":"Department of Obstetrics and Gynaecology Komfo Anokye Teaching Hospital  Kumasi Ghana"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Morrison","family":"Asiamah","sequence":"additional","affiliation":[{"name":"Department of Electron Microscopy and Histopathology Noguchi Memorial Institute for Medical Research University of Ghana  Legon Ghana"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ivan Eduku","family":"Mozu","sequence":"additional","affiliation":[{"name":"Department of Pharmacy Practice Faculty of Pharmacy and Pharmaceutical Sciences Kwame Nkrumah University of Science and Technology  Kumasi Ghana"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nana Ofori","family":"Adomako","sequence":"additional","affiliation":[{"name":"Department of Pharmacy Practice Faculty of Pharmacy and Pharmaceutical Sciences Kwame Nkrumah University of Science and Technology  Kumasi Ghana"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kwaku Gyamfi","family":"Oppong","sequence":"additional","affiliation":[{"name":"Department of Pharmacy Practice Faculty of Pharmacy and Pharmaceutical Sciences Kwame Nkrumah University of Science and Technology  Kumasi Ghana"},{"name":"Directorate of Pharmacy Komfo Anokye Teaching Hospital  Kumasi Ghana"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,1,29]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1155\/2018\/1673517"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12960-019-0353-9"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12884-016-1001-1"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1177\/1745506520973105"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.15436\/2380-5595.17.1243"},{"key":"e_1_2_12_7_1","article-title":"Prevalence, Awareness, and Control of Hypertensive Disorders amongst Pregnant Women Seeking Healthcare in Ghana","volume":"1","author":"Boachie\u2010Ansah P.","year":"2023","journal-title":"Journal of Pregnancy"},{"key":"e_1_2_12_8_1","unstructured":"GHS UNICEF UNFPA WHO AMDD.National Assessment for Emergency Obstetric and Newborn Care Ghana August 2011 Ministry of Health WHO. 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AAbebe. \"Comprehensive Knowledge and Uptake of Cervical Cancer Screening is Low Among Women Living With HIV \/AIDS in Northwest Ethiopia \"Gynecologic Oncology Research and Practice4 (2017):1\u20137.","DOI":"10.1186\/s40661-017-0057-6"},{"key":"e_1_2_12_32_1","doi-asserted-by":"publisher","DOI":"10.1111\/jgs.17373"},{"key":"e_1_2_12_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pec.2018.01.022"},{"key":"e_1_2_12_34_1","doi-asserted-by":"publisher","DOI":"10.3389\/fcvm.2022.886679"},{"key":"e_1_2_12_35_1","doi-asserted-by":"crossref","unstructured":"Y.AgustiniandO.Emilia \u201cThe Effect of Counseling on the Mother's Level of Knowledge and Readiness in Preventing Hypertension Complications in Pregnancy: Scoping Review \u201d in6th International Conference of Health Polytechnic Surabaya (ICoHPS 2023)(Amsterdam:Atlantis Press 2023) 656\u2013667.","DOI":"10.2991\/978-94-6463-324-5_64"},{"key":"e_1_2_12_36_1","first-page":"1","article-title":"Impact of Clinical Pharmacist Education on Knowledge of Pregnancy Induced Hypertension (PIH) Among Pregnant Women","volume":"6","author":"Lavanya S.","year":"2015","journal-title":"International Journal of Pharmacy Teaching and Practices"},{"key":"e_1_2_12_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(22)00847-9"},{"key":"e_1_2_12_38_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0223478"},{"key":"e_1_2_12_39_1","first-page":"366","article-title":"Examining the Efficacy of the Robson Classification System for Optimizing Cesarean Section Rates in South Asia","volume":"12","author":"Hassan L.","year":"2020","journal-title":"Journal of South Asian Federation of Obstetrics and Gynaecology"},{"key":"e_1_2_12_40_1","first-page":"704","article-title":"Caesarean Section in a Primary Health Facility in Ghana: Clinical Indications and Feto\u2010Maternal Outcomes","volume":"8","author":"Prah J.","year":"2017","journal-title":"Journal of Public Health in Africa"}],"container-title":["The Journal of Clinical Hypertension"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jch.70005","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,10]],"date-time":"2025-04-10T07:37:28Z","timestamp":1744270648000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jch.70005"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,1]]},"references-count":39,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2025,1]]}},"alternative-id":["10.1111\/jch.70005"],"URL":"https:\/\/doi.org\/10.1111\/jch.70005","archive":["Portico"],"relation":{},"ISSN":["1524-6175","1751-7176"],"issn-type":[{"value":"1524-6175","type":"print"},{"value":"1751-7176","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,1]]},"assertion":[{"value":"2024-07-15","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-01-13","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-01-29","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70005"}}