{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T17:45:03Z","timestamp":1792691103022,"version":"4.5.0"},"reference-count":23,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,1,29]],"date-time":"2025-01-29T00:00:00Z","timestamp":1738108800000},"content-version":"vor","delay-in-days":28,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100018543","name":"Natural Science Foundation of Tibet Autonomous Region","doi-asserted-by":"publisher","award":["XZ2023ZR\u2010ZY73(Z)"],"award-info":[{"award-number":["XZ2023ZR\u2010ZY73(Z)"]}],"id":[{"id":"10.13039\/501100018543","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Clinical Hypertension"],"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Hemolysis, elevated liver enzymes, low platelet count (HELLP) syndrome is a severe complication of preeclampsia (PE), with a higher incidence rate in people living at high altitudes, such as Tibet area. Maternal HELLP syndrome is associated with an elevated neonatal mortality rate. The purpose of this study was to investigate the predicting factors for neonatal outcomes with maternal HELLP syndrome. We collected 49 PE with HELLP cases and stratified them into the Survival Group (\n                    <jats:italic>n<\/jats:italic>\n                    \u00a0=\u00a028) and Death Group (\n                    <jats:italic>n<\/jats:italic>\n                    \u00a0=\u00a021) based on the neonatal outcomes. We compared the basic characteristics and laboratory indicators using the Student's\n                    <jats:italic>t<\/jats:italic>\n                    \u2010test or the Mann\u2013Whitney\n                    <jats:italic>U<\/jats:italic>\n                    test, followed by univariate and multivariate logistic regression analysis to detect the independent predicting factors for neonatal outcomes. Subsequently, we performed the receiver operating characteristics (ROC) analysis to predict the prognostic power of the variables with a cutoff value. The results indicated that levels of neutrophil\u2010to\u2010lymphocyte ratio (NLR), serum creatinine (Scr), lactic dehydrogenase (LDH), and brain natriuretic peptide (BNP) were significantly elevated, while gestational age (GA) at delivery and alkaline phosphatase (AP) level was significantly decreased in the Death Group. The multivariate regression analysis indicated that only GA at delivery was able to predict the neonatal outcome. The cutoff value was 32.6\u00a0weeks on the ROC curve, with both 85.7% sensitivity and 85.7% specificity (AUC: 0.927, 95% CI: 0.856\u20130.998,\n                    <jats:italic>p<\/jats:italic>\n                    \u00a0&lt;\u00a00.001). Thus, it was concluded that GA at delivery less than 32.6\u00a0weeks was an independent predictor of neonatal death for maternal HELLP syndrome.\n                  <\/jats:p>","DOI":"10.1111\/jch.70007","type":"journal-article","created":{"date-parts":[[2025,1,29]],"date-time":"2025-01-29T08:11:42Z","timestamp":1738138302000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Gestational Age at Delivery Is an Independent Predictor of Neonatal Outcome for Maternal HELLP Syndrome"],"prefix":"10.1111","volume":"27","author":[{"given":"Yan","family":"Shi","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology Women and Children's Hospital of Chongqing Medical University  Chongqing China"},{"name":"Department of Obstetrics and Gynecology Chongqing Health Center for Women and Children  Chongqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoli","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology People's Hospital of Qamdo City  Tibet China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chengqin","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology People's Hospital of Qamdo City  Tibet China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luosong","family":"Zhuoga","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology People's Hospital of Qamdo City  Tibet China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-0543-590X","authenticated-orcid":false,"given":"Dongmei","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Women and Children's Hospital of Chongqing Medical University  Chongqing China"},{"name":"Department of Obstetrics and Gynecology Chongqing Health Center for Women and Children  Chongqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,1,29]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.2174\/1389201019666180712115215"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cnc.2022.04.009"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.29271\/jcpsp.2021.02.188"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0041-1728823"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2009.06.033"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1067\/mob.2003.383"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1080\/14767058.2016.1205022"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12916-020-01534-9"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1080\/14767058.2020.1745181"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1447-0756.2008.00804.x"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41581-019-0119-6"},{"issue":"10","key":"e_1_2_12_13_1","first-page":"721","article-title":"[Diagnosis and treatment guideline of hypertensive disorders in pregnancy (2015)]","volume":"50","author":"Hypertensive Disorders in Pregnancy Subgroup, Chinese Society of Obstetrics and Gynecology, Chinese Medical Association; Hypertensive Disorders in Pregnancy Subgroup Chinese Society of Obstetrics and Gynecology Chinese Medical Association","year":"2015","journal-title":"Zhonghua Fu Chan Ke Za Zhi"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.3109\/14767058.2015.1111332"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2012.11.025"},{"key":"e_1_2_12_16_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12884-022-04466-9"},{"key":"e_1_2_12_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9378(90)90376-I"},{"key":"e_1_2_12_18_1","doi-asserted-by":"publisher","DOI":"10.3109\/10641955.2010.507849"},{"key":"e_1_2_12_19_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.ackd.2020.06.002"},{"key":"e_1_2_12_20_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11255-019-02111-7"},{"key":"e_1_2_12_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2023.04.046"},{"key":"e_1_2_12_22_1","doi-asserted-by":"publisher","DOI":"10.1159\/000082648"},{"key":"e_1_2_12_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(15)00070-7"},{"key":"e_1_2_12_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.placenta.2010.04.014"}],"container-title":["The Journal of Clinical Hypertension"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jch.70007","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,10]],"date-time":"2025-04-10T03:37:23Z","timestamp":1744256243000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jch.70007"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,1]]},"references-count":23,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2025,1]]}},"alternative-id":["10.1111\/jch.70007"],"URL":"https:\/\/doi.org\/10.1111\/jch.70007","archive":["Portico"],"relation":{},"ISSN":["1524-6175","1751-7176"],"issn-type":[{"value":"1524-6175","type":"print"},{"value":"1751-7176","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,1]]},"assertion":[{"value":"2024-11-04","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-01-13","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-01-29","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70007"}}