{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,11]],"date-time":"2026-07-11T06:31:16Z","timestamp":1783751476477,"version":"3.55.0"},"reference-count":45,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2025,7,8]],"date-time":"2025-07-08T00:00:00Z","timestamp":1751932800000},"content-version":"vor","delay-in-days":7,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Clinical Hypertension"],"published-print":{"date-parts":[[2025,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p>Blood pressure (BP) is a dynamic vital sign with variability. Novel metrics that account for BP variability and longitudinal control are gaining interest, such as time in target range (TTR) assessments. TTR is the percentage of time a patient's BP is within a desired range. We sought to determine if systolic BP TTR was associated with major adverse cardiovascular events (MACE) among participants in the PRECISION (Prospective Randomized Evaluation of Celecoxib Integrated Safety versus Ibuprofen or Naproxen) trial. PRECISION was a 24\u00a0081\u2010participant cardiovascular (CV) outcomes trial comparing celecoxib, naproxen, or ibuprofen in participants with increased CV risk. Systolic BP was in the target range if it was between 110 and 130\u00a0mm\u00a0Hg. TTR was determined via traditional and Rosendaal linear interpolation (RLI) methods. Participants were categorized based on TTR achieved, &lt;25%, 25%\u2013&lt;50%, 50%\u2013&lt;75%, or \u226575%. Hazard ratios (HR) and Kaplan\u2013Meier survival curves were generated. Twenty thousand four hundred and eighty\u2010seven participants had at least four BP readings available for analysis and a median follow\u2010up of 27.6\u00a0\u00b1\u00a05.4\u00a0months. The cohort had a mean baseline BP of 125.2\u00a0mm\u00a0Hg and a mean systolic BP of 127.5\u00a0mm\u00a0Hg when accounting for all follow\u2010up visits. A lower risk of MACE was observed among individuals with \u226575% TTR compared with those &lt;25% using the traditional (adjusted HR 0.70, 95% CI 0.52\u20130.95, <jats:italic>p<\/jats:italic>\u00a0=\u00a00.02) and RLI method (adjusted HR 0.56, 95% CI 0.43\u20130.75, <jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.001). More systolic BP TTR is associated with a lower risk of MACE among individuals in PRECISION.<\/jats:p>","DOI":"10.1111\/jch.70009","type":"journal-article","created":{"date-parts":[[2025,7,8]],"date-time":"2025-07-08T14:54:11Z","timestamp":1751986451000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Association of Systolic Blood Pressure Time in Target Range With Cardiovascular Events Among PRECISION Participants"],"prefix":"10.1111","volume":"27","author":[{"given":"Neel","family":"Agarwal","sequence":"first","affiliation":[{"name":"Ohio State University College of Medicine  Columbus Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julie","family":"St. John","sequence":"additional","affiliation":[{"name":"Cleveland Clinic Coordinating Center for Clinical Research  Cleveland Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vikas","family":"Sunder","sequence":"additional","affiliation":[{"name":"Department of Cardiovascualr Medicine Section of Preventive Cardiology, Cleveland Clinic  Cleveland Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ashish","family":"Sarraju","sequence":"additional","affiliation":[{"name":"Cleveland Clinic Coordinating Center for Clinical Research  Cleveland Ohio USA"},{"name":"Department of Cardiovascualr Medicine Section of Preventive Cardiology, Cleveland Clinic  Cleveland Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3262-792X","authenticated-orcid":false,"given":"Luke J.","family":"Laffin","sequence":"additional","affiliation":[{"name":"Cleveland Clinic Coordinating Center for Clinical Research  Cleveland Ohio USA"},{"name":"Department of Cardiovascualr Medicine Section of Preventive Cardiology, Cleveland Clinic  Cleveland Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,7,8]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2022.11.005"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.120.15026"},{"issue":"6","key":"e_1_2_12_4_1","first-page":"e13","article-title":"2017 ACC\/AHA\/AAPA\/ABC\/ACPM\/AGS\/APhA\/ASH\/ASPC\/NMA\/PCNA Guideline for the Prevention, Detection, Evaluation, and Management of High Blood Pressure in Adults: A Report of the American College of Cardiology\/American Heart Association Task Force on Clinical Practice Guidelines","volume":"71","author":"Whelton P. 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