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This study assessed the relationship between hyperuricemia and incident hypertension, examining serum uric acid (SUA) cut\u2010offs using both traditional and new definitions in a large Taiwanese cohort. This observational cohort study enrolled 26 973 participants from the Taiwan Biobank (TWB), followed for a median of 4 years. Regarding traditional definition (140\/90\u00a0mmHg), hyperuricemia (odds ratio [OR], 1.297), quartile 3 of SUA (OR, 1.211), quartile 4 of SUA (OR, 1.495), and high SUA (OR, 1.127) were significantly associated with incident hypertension in males, and hyperuricemia (OR, 1.198), quartile 4 of SUA (OR, 1.359), and high SUA (OR, 1.099) were significantly associated with incident hypertension in females. As for new definition (130\/80\u00a0mmHg), hyperuricemia (OR, 1.376), quartile 3 of SUA (OR, 1.229), quartile 4 of SUA (OR, 1.554), and high SUA (OR, 1.139) were associated with incident hypertension in males, and hyperuricemia (OR, 1.249), quartile 3 of SUA (OR, 1.253), quartile 4 of SUA (OR, 1.429), and high SUA (OR, 1.096) were associated with incident hypertension in females. The interaction between hyperuricemia and sex on incident hypertension was significant for both traditional (140\/90, <jats:italic>p<\/jats:italic> &lt; 0.001) and new (130\/80, <jats:italic>p<\/jats:italic> = 0.001) definitions. Hyperuricemia was significantly associated with incident hypertension under both traditional and new definitions. A significant interaction between hyperuricemia and sex was noted, although the differences were not so great.<\/jats:p>","DOI":"10.1111\/jch.70013","type":"journal-article","created":{"date-parts":[[2025,2,11]],"date-time":"2025-02-11T13:51:00Z","timestamp":1739281860000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Impact of Hyperuricemia on Incident Hypertension When Hypertension Definition Changes From 140\/90 to 130\/80\u00a0mmHg in a Large Taiwanese Population Follow\u2010Up Study"],"prefix":"10.1111","volume":"27","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6915-3679","authenticated-orcid":false,"given":"Yi\u2010Hsueh","family":"Liu","sequence":"first","affiliation":[{"name":"Graduate Institute of Clinical Medicine, College of Medicine, Kaohsiung Medical University  Kaohsiung Taiwan"},{"name":"Department of Internal Medicine Kaohsiung Municipal Siaogang Hospital, Kaohsiung Medical University  Kaohsiung Taiwan"},{"name":"Division of Cardiology, Department of Internal Medicine Kaohsiung Medical University Hospital  Kaohsiung Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wei\u2010Yu","family":"Su","sequence":"additional","affiliation":[{"name":"Department of General Medicine Kaohsiung Medical University Hospital, Kaohsiung Medical University  Kaohsiung Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chih\u2010Yi","family":"Lin","sequence":"additional","affiliation":[{"name":"Department of Environmental and Occupational Medical Center Kaohsiung Municipal Siaogang Hospital, Kaohsiung Medical University  Kaohsiung Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chun\u2010Chi","family":"Tsai","sequence":"additional","affiliation":[{"name":"Department of Occupational Safety and Health Kaohsiung Municipal Siaogang Hospital, Kaohsiung Medical University  Kaohsiung Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ho\u2010Ming","family":"Su","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Kaohsiung Municipal Siaogang Hospital, Kaohsiung Medical University  Kaohsiung Taiwan"},{"name":"Division of Cardiology, Department of Internal Medicine Kaohsiung Medical University Hospital  Kaohsiung Taiwan"},{"name":"School of Medicine, College of Medicine, Kaohsiung Medical University  Kaohsiung Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Szu\u2010Chia","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Kaohsiung Municipal Siaogang Hospital, Kaohsiung Medical University  Kaohsiung Taiwan"},{"name":"School of Medicine, College of Medicine, Kaohsiung Medical University  Kaohsiung Taiwan"},{"name":"Division of Nephrology, Department of Internal Medicine Kaohsiung Medical University Hospital, Kaohsiung Medical University  Kaohsiung Taiwan"},{"name":"Research Center for Precision Environmental Medicine, Kaohsiung Medical University  Kaohsiung Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,2,7]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41569\u2010021\u201000559\u20108"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0140\u20106736(08)60655\u20108"},{"issue":"1","key":"e_1_2_9_4_1","first-page":"S3","article-title":"Epidemiology and Risk of Hypertension in the Elderly: The Framingham Study","volume":"6","author":"Vokonas P. 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