{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T01:43:05Z","timestamp":1791855785216,"version":"4.3.4"},"reference-count":23,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2025,3,18]],"date-time":"2025-03-18T00:00:00Z","timestamp":1742256000000},"content-version":"vor","delay-in-days":17,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004826","name":"Natural Science Foundation of Beijing Municipality","doi-asserted-by":"publisher","award":["7222143"],"award-info":[{"award-number":["7222143"]}],"id":[{"id":"10.13039\/501100004826","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Clinical Hypertension"],"published-print":{"date-parts":[[2025,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p>The weight\u2010adjusted waist index (WWI) is a novel indicator that could estimate body fat and muscle mass. This study aimed to investigate the relationship between WWI and hypertension plus hyperuricemia (HTN\u2010HUA). The data were obtained from the National Health and Nutrition Examination Survey (NHANES) database from 1999 to 2018. Logistic regression analyses were used to explore the association between WWI with HTN\u2010HUA, hypertension (HTN) alone, and hyperuricemia (HUA) alone. Restricted cubic spline (RCS) analyses were employed to examine potential nonlinear associations. Receiver operating characteristic (ROC) curves were utilized to assess the predictive ability of WWI. A total of 16 294 participants were included, among whom 2280 (12%) were diagnosed with HTN\u2010HUA, 5148 (28%) with HTN alone, and 1252 (9%) with HUA alone. WWI was significantly associated with HTN\u2010HUA, HTN alone, and HUA alone after adjusting for potential confounders. Compared to the lowest quartiles of WWI, the odds ratios of the highest quartiles were 2.13 (95% confidence interval [CI]: 1.59\u20132.83) for HTN\u2010HUA, 1.28 (95% CI: 1.08\u20131.5) for HTN alone, and 1.6 (95% CI: 1.18\u20132.16) for HUA alone. RCS analyses demonstrated a nonlinear association between WWI and HTN\u2010HUA. The fully adjusted model, which included WWI, exhibited a moderate predictive ability for HTN\u2010HUA (area under the curve [AUC]: 0.804, 95% CI 0.796\u20130.813). The association between WWI and HTN\u2010HUA was more prominent among young individuals and those with normal weight. The study suggested that a significant and nonlinear association between WWI and HTN\u2010HUA. WWI had the potential to facilitate the early detection of HTN\u2010HUA.<\/jats:p>","DOI":"10.1111\/jch.70022","type":"journal-article","created":{"date-parts":[[2025,3,18]],"date-time":"2025-03-18T18:42:03Z","timestamp":1742323323000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Weight\u2010Adjusted Waist Index May Predict Hypertension Plus Hyperuricemia"],"prefix":"10.1111","volume":"27","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3986-1804","authenticated-orcid":false,"given":"Huanhuan","family":"Miao","sequence":"first","affiliation":[{"name":"State Key Laboratory of Cardiovascular Disease, Heart Failure Center, National Center for Cardiovascular Diseases, Fuwai Hospital Chinese Academy of Medical Sciences and Peking Union Medical College  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhanyang","family":"Zhou","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Cardiovascular Disease, Heart Failure Center, National Center for Cardiovascular Diseases, Fuwai Hospital Chinese Academy of Medical Sciences and Peking Union Medical College  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zheng","family":"Yin","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Cardiovascular Disease, Heart Failure Center, National Center for Cardiovascular Diseases, Fuwai Hospital Chinese Academy of Medical Sciences and Peking Union Medical College  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xue","family":"Li","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Cardiovascular Disease, Heart Failure Center, National Center for Cardiovascular Diseases, Fuwai Hospital Chinese Academy of Medical Sciences and Peking Union Medical College  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuhui","family":"Zhang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Cardiovascular Disease, Heart Failure Center, National Center for Cardiovascular Diseases, Fuwai Hospital Chinese Academy of Medical Sciences and Peking Union Medical College  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8142-8305","authenticated-orcid":false,"given":"Yuqing","family":"Zhang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Cardiovascular Disease, Heart Failure Center, National Center for Cardiovascular Diseases, Fuwai Hospital Chinese Academy of Medical Sciences and Peking Union Medical College  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian","family":"Zhang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Cardiovascular Disease, Heart Failure Center, National Center for Cardiovascular Diseases, Fuwai Hospital Chinese Academy of Medical Sciences and Peking Union Medical College  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,3,18]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"crossref","DOI":"10.1016\/j.metabol.2024.155999","article-title":"Global Burden of Metabolic Diseases, 1990\u20132021","volume":"160","author":"Zhang H.","year":"2024","journal-title":"Metabolism"},{"key":"e_1_2_11_3_1","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1001\/jama.2019.9811","article-title":"Association of Office and Ambulatory Blood Pressure With Mortality and Cardiovascular Outcomes","volume":"322","author":"Yang W. 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The PIUMA Study","volume":"36","author":"Verdecchia P.","year":"2000","journal-title":"Hypertension"},{"key":"e_1_2_11_8_1","doi-asserted-by":"crossref","first-page":"776","DOI":"10.1186\/s12889-021-10858-x","article-title":"Combined Effect of Hypertension and Hyperuricemia on Ischemic Stroke in a Rural Chinese Population","volume":"21","author":"Sun P.","year":"2021","journal-title":"BMC Public Health [Electronic Resource]"},{"key":"e_1_2_11_9_1","first-page":"603","article-title":"2024 Chinese Guidelines for Prevention and Treatment of Hypertension","volume":"32","author":"Joint Committee for Guideline Revision","year":"2024","journal-title":"Chinese Journal of Hypertension"},{"key":"e_1_2_11_10_1","doi-asserted-by":"crossref","first-page":"1874","DOI":"10.1097\/HJH.0000000000003480","article-title":"2023 ESH Guidelines for the Management of Arterial Hypertension The Task Force for the Management of Arterial Hypertension of the European Society of Hypertension: Endorsed by the International Society of Hypertension (ISH) and the European Renal Association (ERA)","volume":"41","author":"Mancia G.","year":"2023","journal-title":"Journal of Hypertension"},{"key":"e_1_2_11_11_1","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1002\/oby.20181","article-title":"Obesity\u2010Related Hypertension: Pathogenesis, Cardiovascular Risk, and Treatment\u2013A Position Paper of the Obesity Society and The American Society of Hypertension","volume":"21","author":"Landsberg L.","year":"2013","journal-title":"Obesity (Silver Spring)"},{"key":"e_1_2_11_12_1","doi-asserted-by":"crossref","DOI":"10.1016\/j.heliyon.2024.e27074","article-title":"Associations Between Obesity and Hyperuricemia Combing Mendelian Randomization With Network Pharmacology","volume":"10","author":"Panlu K.","year":"2024","journal-title":"Heliyon"},{"key":"e_1_2_11_13_1","doi-asserted-by":"crossref","first-page":"2046","DOI":"10.1111\/jdi.13573","article-title":"Insulin Resistance Surrogates Predict Hypertension Plus Hyperuricemia","volume":"12","author":"Li Y.","year":"2021","journal-title":"Journal of Diabetes Investigation"},{"key":"e_1_2_11_14_1","doi-asserted-by":"crossref","first-page":"3593","DOI":"10.2147\/DMSO.S482184","article-title":"Insulin Resistance Surrogates May Predict HTN\u2010HUA in Young, Non\u2010Obese Individuals","volume":"17","author":"Zuo Y. 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