{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T20:45:49Z","timestamp":1792788349760,"version":"4.5.0"},"reference-count":25,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"vor","delay-in-days":31,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82322060"],"award-info":[{"award-number":["82322060"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Clinical Hypertension"],"published-print":{"date-parts":[[2025,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p>Diabetes has emerged as a pressing public health crisis in numerous nations, with individuals afflicted by hypertension exhibiting an elevated susceptibility to diabetes. Our main objective was to investigate the risk of developing new\u2010onset diabetes in hypertensive patients with pre\u2010diabetes undergoing treatment with angiotensin\u2010converting enzyme inhibitors (ACEIs) and angiotensin receptor blockers (ARBs), thereby furnishing valuable evidence for informed clinical decision\u2010making. Our study was a retrospective cohort study in which individuals with hypertension and meeting other inclusion criteria were enrolled into the cohort. The study population was divided into two groups: one group receiving ARBs or ACEIs as antihypertensive medications, and the other group receiving calcium antagonists, diuretics, beta\u2010blockers, or alpha\u2010blockers. Kaplan\u2013Meier curve and Cox proportional hazard model were used to evaluate the cumulative incidence and hazard ratio (HR) of new\u2010onset diabetes in the ARBs or ACEIs grouprespectively. Out of the 1373 hypertensive individualswith pre\u2010diabetes included in the study, 385 were prescribed ARBs or ACEIs for hypertension management. Subsequent follow\u2010up revealed that 24 new cases of diabetes emerged in the ARBs or ACEIs group, whereas 104 cases were reported in the comparison group. Utilization of ARBs or ACEIs as antihypertensive therapy was linked to a decreased risk of incident diabetes compared to the alternative regimen (HR: 0.51, 95% CI: 0.33, 0.79) and was statistically significant in the male population. In conclusion, antihypertensive drugs of the ACEIs and ARBs class reduce the risk of new\u2010onset diabetes in patients with hypertension combinedwith pre\u2010diabetes.<\/jats:p>","DOI":"10.1111\/jch.70025","type":"journal-article","created":{"date-parts":[[2025,6,2]],"date-time":"2025-06-02T06:45:08Z","timestamp":1748846708000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Reducing the Risk of Developing Diabetes: The Role of Angiotensin Receptor Blockers and Angiotensin Converting Enzyme Inhibitors in Patients With Hypertension Combined Prediabetes"],"prefix":"10.1111","volume":"27","author":[{"given":"Chenyu","family":"Yang","sequence":"first","affiliation":[{"name":"School of Public Health and Emergency Management Southern University of Science and Technology  Shenzhen Guangdong China"},{"name":"Shaanxi Provincial Center for Disease Control and Prevention No. 3 Jiandong Street  Xi'an China"},{"name":"Department of Epidemiology and Health Statistics School of Public Health Xi'an Jiaotong University Health Science Center  Xi'an China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhiping","family":"Hu","sequence":"additional","affiliation":[{"name":"Shaanxi Provincial Center for Disease Control and Prevention No. 3 Jiandong Street  Xi'an China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rina","family":"Sa","sequence":"additional","affiliation":[{"name":"Shaanxi Provincial Center for Disease Control and Prevention No. 3 Jiandong Street  Xi'an China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rongjing","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Health Statistics School of Public Health Xi'an Jiaotong University Health Science Center  Xi'an China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Health Statistics School of Public Health Xi'an Jiaotong University Health Science Center  Xi'an China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Youwei","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Health Statistics School of Public Health Xi'an Jiaotong University Health Science Center  Xi'an China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guoshuai","family":"Shi","sequence":"additional","affiliation":[{"name":"School of Public Health Xi'an Medical University  Xi'an China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lin","family":"Qiu","sequence":"additional","affiliation":[{"name":"Shaanxi Provincial Center for Disease Control and Prevention No. 3 Jiandong Street  Xi'an China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4417-1739","authenticated-orcid":false,"given":"Chao","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Health Statistics School of Public Health Xi'an Jiaotong University Health Science Center  Xi'an China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,6]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.2174\/1573399819666230413094200"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(20)30925-9"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bcp.2022.115304"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2015.07.059"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2007.05.057"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000000590"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000001495"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1080\/03014460.2022.2072525"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2011.01.064"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2012.06.125"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcmm.13096"},{"issue":"6","key":"e_1_2_12_13_1","first-page":"e13","article-title":"ACC\/AHA\/AAPA\/ABC\/ACPM\/AGS\/APhA\/ASH\/ASPC\/NMA\/PCNA Guideline for the Prevention, Detection, Evaluation, and Management of High Blood Pressure in Adults: A Report of the American College of Cardiology\/American Heart Association Task Force on Clinical Practice Guidelines","volume":"71","author":"Whelton P. K.","year":"2018","journal-title":"Hypertension"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehy339"},{"key":"e_1_2_12_15_1","first-page":"1804","article-title":"Effect of Angiotensin Receptor Blockers in the Prevention of Type 2 Diabetes and Cardiovascular Events: A Meta\u2010Analysis of Randomized Trials","volume":"125","author":"Song H. F.","year":"2012","journal-title":"Chinese Medical Journal"},{"key":"e_1_2_12_16_1","doi-asserted-by":"publisher","DOI":"10.1038\/ajh.2011.8"},{"key":"e_1_2_12_17_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc07-1768"},{"key":"e_1_2_12_18_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11892-018-0976-6"},{"key":"e_1_2_12_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(21)01920-6"},{"key":"e_1_2_12_20_1","doi-asserted-by":"publisher","DOI":"10.1155\/2020\/5342161"},{"issue":"20","key":"e_1_2_12_21_1","first-page":"S360","article-title":"ACE Inhibitor or ARB Treatment Among Patients With Diabetes and Chronic Kidney Disease","volume":"27","author":"Fried L. F.","year":"2021","journal-title":"American Journal of Managed Care"},{"key":"e_1_2_12_22_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.105.594986"},{"key":"e_1_2_12_23_1","doi-asserted-by":"publisher","DOI":"10.2147\/VHRM.S7263"},{"key":"e_1_2_12_24_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40292-020-00408-8"},{"key":"e_1_2_12_25_1","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.121.17981"},{"key":"e_1_2_12_26_1","doi-asserted-by":"publisher","DOI":"10.1530\/JOE-23-0245"}],"container-title":["The Journal of Clinical Hypertension"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jch.70025","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,6,12]],"date-time":"2025-06-12T18:19:23Z","timestamp":1749752363000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jch.70025"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,5]]},"references-count":25,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2025,5]]}},"alternative-id":["10.1111\/jch.70025"],"URL":"https:\/\/doi.org\/10.1111\/jch.70025","archive":["Portico"],"relation":{},"ISSN":["1524-6175","1751-7176"],"issn-type":[{"value":"1524-6175","type":"print"},{"value":"1751-7176","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,5]]},"assertion":[{"value":"2024-12-12","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-02-20","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-06-01","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70025"}}