{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T09:57:13Z","timestamp":1785491833097,"version":"3.56.0"},"reference-count":21,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2025,3,11]],"date-time":"2025-03-11T00:00:00Z","timestamp":1741651200000},"content-version":"vor","delay-in-days":10,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82170449"],"award-info":[{"award-number":["82170449"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Clinical Hypertension"],"published-print":{"date-parts":[[2025,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p>We conducted a retrospective cohort study to investigate changes in the aldosterone\u2010to\u2010renin ratio (ARR) and other influencing factors in patients with renal artery stenosis (RAS) and primary aldosteronism (PA). Patients with RAS and PA admitted to our hospital between January 2016 and December 2021 were retrospectively selected. Based on the standardized PA screening results, the patients were divided into aldosterone\u2010to\u2010renin ratio\u2010positive and \u2010negative groups. The clinical features of the patients were compared. Binary logistic regression analysis was performed to identify the factors contributing to the comorbidity of RAS with false\u2010negative PA. A total of 78 patients (mean age: 60.2\u00a0\u00b1\u00a010.2 years) were selected, among whom 46 (59%) were male. Overall, 69 patients had Stage 3 hypertension (88.5%) and 57 had hypokalemia (73.1%). Additionally, 42 (53.8%) and 36 (46.2%) patients were aldosterone\u2010to\u2010renin ratio\u2010positive and \u2010negative, respectively. The aldosterone\u2010to\u2010renin ratio\u2010positive group showed significant differences in malignant hypertension (2.4% vs. 27.8%; <jats:italic>p\u00a0<\/jats:italic>=\u00a00.002), Stage 3 hypertension (81.0% vs. 97.2%; <jats:italic>p\u00a0<\/jats:italic>=\u00a00.033), and RAS degree (64.3\u00a0\u00b1\u00a016.4% vs. 71.8\u00a0\u00b1\u00a014.4%; <jats:italic>p\u00a0<\/jats:italic>=\u00a00.032). Malignant hypertension (odds ratio, 15.250; 95% confidence interval, 1.787\u2013130.132; <jats:italic>p\u00a0<\/jats:italic>=\u00a00.013) and RAS degree (odds ratio, 1.034; 95% confidence interval, 1.002\u20131.068; <jats:italic>p\u00a0<\/jats:italic>=\u00a00.036) influenced the comorbidity of RAS with false\u2010negative PA. Malignant hypertension and severe RAS can contribute to false\u2010negative PA results. Therefore, PA screening test results should be carefully analyzed and rechecked following RAS treatment to confirm the presence of PA.<\/jats:p>","DOI":"10.1111\/jch.70031","type":"journal-article","created":{"date-parts":[[2025,3,11]],"date-time":"2025-03-11T23:59:08Z","timestamp":1741737548000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Aldosterone\u2010to\u2010Renin Ratio Changes in Patients With Renal Artery Stenosis and Aldosteronism"],"prefix":"10.1111","volume":"27","author":[{"ORCID":"https:\/\/orcid.org\/0009-0007-3335-9553","authenticated-orcid":false,"given":"Qian","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Cardiology State Key Laboratory of Cardiovascular Disease Fuwai Hospital National Center for Cardiovascular Diseases Chinese Academy of Medical Sciences and Peking Union Medical College  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6236-9805","authenticated-orcid":false,"given":"Hui","family":"Dong","sequence":"additional","affiliation":[{"name":"Department of Cardiology State Key Laboratory of Cardiovascular Disease Fuwai Hospital National Center for Cardiovascular Diseases Chinese Academy of Medical Sciences and Peking Union Medical College  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongwu","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Cardiology State Key Laboratory of Cardiovascular Disease Fuwai Hospital National Center for Cardiovascular Diseases Chinese Academy of Medical Sciences and Peking Union Medical College  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yujie","family":"Zuo","sequence":"additional","affiliation":[{"name":"Department of Cardiology State Key Laboratory of Cardiovascular Disease Fuwai Hospital National Center for Cardiovascular Diseases Chinese Academy of Medical Sciences and Peking Union Medical College  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yubao","family":"Zou","sequence":"additional","affiliation":[{"name":"Department of Cardiology State Key Laboratory of Cardiovascular Disease Fuwai Hospital National Center for Cardiovascular Diseases Chinese Academy of Medical Sciences and Peking Union Medical College  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiongjing","family":"Jiang","sequence":"additional","affiliation":[{"name":"Department of Cardiology State Key Laboratory of Cardiovascular Disease Fuwai Hospital National Center for Cardiovascular Diseases Chinese Academy of Medical Sciences and Peking Union Medical College  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,3,11]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/10.1080\/00015458.2012.11680843"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/10.1080\/10641963.2020.1790586"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/10.3389\/fcvm.2022.818872"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.3760\/cma.j.issn.0376\u20102491.2019.11.008"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/10.1016\/bs.vh.2018.10.006"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/10.1210\/jc.2008\u20100104"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/10.1097\/CRD.0000000000000281"},{"key":"e_1_2_11_9_1","first-page":"326","article-title":"Ben Abdallah N. Resistant Hypertension Secondary to Coexisting Primary Hyperaldosteronism and Renal Artery Stenosis","volume":"96","author":"Oueslati I.","year":"2018","journal-title":"La Tunisie Medicale"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/10.1097\/01.hjh.0000187260.32567.75"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/10.1210\/clinem\/dgz306"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/10.3390\/ijms20205214"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/10.1016\/j.ijcard.2016.01.200"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/10.1161\/CIRCULATIONAHA.118.033348"},{"key":"e_1_2_11_15_1","first-page":"401","article-title":"Renal Abnormalities and Vascular Complications in Primary Hyperaldosteronism. Evidence on Tertiary Hyperaldosteronism","volume":"45","author":"Beevers D. G.","year":"1976","journal-title":"Quarterly Journal of Medicine"},{"key":"e_1_2_11_16_1","first-page":"203","article-title":"Pseudo\u2010Primary Aldosteronism. An Entity Distinct From True Primary Aldosteronism","volume":"27","author":"Baer L.","year":"1970","journal-title":"Circulation Research"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/10.1016\/j.cdtm.2019.12.009"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/10.3904\/kjim.2014.29.2.217"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/10.1111\/j.1365\u20102265.2007.02775.x"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/10.1530\/EJE\u201017\u20100990"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/10.1210\/jc.2015\u20104061"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/10.1097\/HJH.0000000000002510"}],"container-title":["The Journal of Clinical Hypertension"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jch.70031","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,3,29]],"date-time":"2025-03-29T18:45:17Z","timestamp":1743273917000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jch.70031"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,3]]},"references-count":21,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2025,3]]}},"alternative-id":["10.1111\/jch.70031"],"URL":"https:\/\/doi.org\/10.1111\/jch.70031","archive":["Portico"],"relation":{},"ISSN":["1524-6175","1751-7176"],"issn-type":[{"value":"1524-6175","type":"print"},{"value":"1751-7176","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,3]]},"assertion":[{"value":"2024-12-22","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-02-25","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-03-11","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70031"}}