{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T08:45:08Z","timestamp":1792226708882,"version":"4.4.0"},"reference-count":49,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T00:00:00Z","timestamp":1745452800000},"content-version":"vor","delay-in-days":23,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100010256","name":"Guangzhou Municipal Science and Technology Project","doi-asserted-by":"publisher","award":["2024A03J1021"],"award-info":[{"award-number":["2024A03J1021"]}],"id":[{"id":"10.13039\/501100010256","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Clinical Hypertension"],"published-print":{"date-parts":[[2025,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p>Emerging evidence links the Endothelial Activation and Stress Index (EASIX) and mortality risk in coronary artery disease, but its relevance in hypertensive patients remains unclear. This study examines the association between EASIX and all\u2010cause and cardiovascular mortality in hypertensive individuals. The analysis included 6138 hypertensive patients from seven National Health and Nutrition Examination Survey (NHNES) cycles (2003\u20132016), with mortality data obtained from the National Death Index (NDI). Over a median follow\u2010up of 98 months, 1435 (23.4%) participants died, including 400 (6.5%) from cardiovascular causes. Restricted cubic spline analysis revealed a positive association between EASIX and both all\u2010cause and cardiovascular mortality. Weighted multivariable Cox regression indicated that each 1\u2010unit increase in EASIX corresponding to a 25% and 23% rise in mortality risk, respectively. Based on the optimal cutoff value determined using the maximally selected rank statistics method, participants were stratified into higher (&gt;0.79) and lower (\u22640.79) EASIX groups. Higher EASIX was significantly associated with increased all\u2010cause mortality risk (HR 1.46, 95% CI 1.23\u20131.73, <jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.0001). Higher EASIX scores were associated with increased cardiovascular mortality, especially in former\/current smokers and those with diabetes\/prediabetes. Time\u2010dependent receiver operating characteristic analysis assessed the predictive accuracy of EASIX, yielding area under the curve (AUC) for 1\u2010, 3\u2010, 5\u2010, and 10\u2010year survival of 0.71, 0.67, 0.67, and 0.67 for all\u2010cause mortality and 0.79, 0.73, 0.73, and 0.71 for cardiovascular mortality. In conclusion, elevated EASIX is independently associated with increased all\u2010cause and cardiovascular mortality in hypertensive patients, suggesting its potential as a predictive biomarker in clinical practice.<\/jats:p>","DOI":"10.1111\/jch.70057","type":"journal-article","created":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T09:11:20Z","timestamp":1745485880000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["Endothelial Activation and Stress Index Predicts All\u2010Cause and Cardiovascular Mortality in Hypertensive Individuals: A Nationwide Study"],"prefix":"10.1111","volume":"27","author":[{"ORCID":"https:\/\/orcid.org\/0009-0001-0634-9874","authenticated-orcid":false,"given":"Gaiying","family":"Dong","sequence":"first","affiliation":[{"name":"Department of Medical Ultrasound Guangzhou First People's Hospital South China University of Technology Guangzhou Guangdong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tingting","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery Anhui Public Health Clinical Center the First Affiliated Hospital of Anhui University North District Hefei Anhui China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaofan","family":"Gu","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine Guangzhou First People's Hospital South China University of Technology Guangzhou Guangdong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9178-8440","authenticated-orcid":false,"given":"Liangliang","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Hematology Guangzhou First People's Hospital South China University of Technology Guangzhou Guangdong China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,4,24]]},"reference":[{"key":"e_1_2_14_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41581-019-0244-2"},{"key":"e_1_2_14_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(21)01330-1"},{"key":"e_1_2_14_4_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.115.018912"},{"key":"e_1_2_14_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00467-022-05802-z"},{"key":"e_1_2_14_6_1","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.114.03575"},{"key":"e_1_2_14_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41409-024-02270-x"},{"key":"e_1_2_14_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2352-3026(17)30108-4"},{"key":"e_1_2_14_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtct.2023.11.016"},{"key":"e_1_2_14_10_1","doi-asserted-by":"publisher","DOI":"10.1182\/bloodadvances.2022008617"},{"key":"e_1_2_14_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41409-023-01922-8"},{"key":"e_1_2_14_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41409-022-01829-w"},{"key":"e_1_2_14_13_1","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.2019.238790"},{"key":"e_1_2_14_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00392-024-02534-y"},{"key":"e_1_2_14_15_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12933-023-01998-y"},{"key":"e_1_2_14_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12020-024-04075-w"},{"key":"e_1_2_14_17_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41409-022-01874-5"},{"key":"e_1_2_14_18_1","doi-asserted-by":"publisher","DOI":"10.3389\/fcvm.2022.919956"},{"key":"e_1_2_14_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.hrtlng.2025.02.003"},{"key":"e_1_2_14_20_1","first-page":"1","article-title":"National Health and Nutrition Examination Survey: Analytic Guidelines, 1999\u20132010","volume":"161","author":"Johnson C. 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