{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T23:27:34Z","timestamp":1789687654538,"version":"4.0.1"},"reference-count":33,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2025,5,10]],"date-time":"2025-05-10T00:00:00Z","timestamp":1746835200000},"content-version":"vor","delay-in-days":9,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Clinical Hypertension"],"published-print":{"date-parts":[[2025,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p>Hyponatremia is a crucial complication of therapy with thiazide diuretics. This study compares the epidemiological and biochemical profiles and hospital course of patients using hydrochlorothiazide (HCTZ), indapamide (INDA), and chlorthalidone (CTD) admitted with thiazide\u2010associated hyponatremia (TAH). Data were obtained retrospectively from the hospital's digital registries. The epidemiological and biochemical parameters between the HCTZ, INDA, and CTD groups were compared. The correlation between dose and biochemical parameters in each group was performed. The thiazide groups without diuretic co\u2010medication were compared (HCTZ vs. INDA), and the correlation between dose and biochemical parameters in each group was examined. A comparison of the HCTZ (<jats:italic>n<\/jats:italic> = 135), INDA (<jats:italic>n<\/jats:italic> = 125), and CTD (<jats:italic>n<\/jats:italic> = 27) groups identified differences in serum potassium (s\u2010K; <jats:italic>p<\/jats:italic> = 0.03). The hyponatremia correction rate was slower in the CTD group at 96\u00a0h after admission (<jats:italic>p<\/jats:italic> &lt; 0.001). After the exclusion of diuretic co\u2010medication, the HCTZ group (<jats:italic>n<\/jats:italic> = 64\/135) showed a higher prevalence of ARBs, s\u2010K (both <jats:italic>p<\/jats:italic> &lt; 0.001), and a lower median (IQR) equipotent dose (12.5 (o) mg vs. 2.5 (1.2) mg), prevalence of ACE\u2010I (<jats:italic>p<\/jats:italic> &lt; 0.001), and eGFR (<jats:italic>p<\/jats:italic> = 0.03), when compared to the INDA group (<jats:italic>n<\/jats:italic> = 109\/125). In conclusion, except for s\u2010K, we observed no significant difference in biochemical and epidemiological profiles between HCTZ, INDA, and CTD. After excluding the influence of other diuretics, we observed higher s\u2010K in the HCTZ group compared to the INDA group, potentially explained by the lower equipotent dose of HCTZ. The CTD group showed a statistically significant trend of slower hyponatremia correction.<\/jats:p>","DOI":"10.1111\/jch.70060","type":"journal-article","created":{"date-parts":[[2025,5,10]],"date-time":"2025-05-10T07:45:40Z","timestamp":1746863140000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Thiazide\u2010Associated Hyponatremia: A Retrospective Cohort Study Comparing Hydrochlorothiazide Versus Indapamide Versus Chlorthalidone"],"prefix":"10.1111","volume":"27","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8331-2525","authenticated-orcid":false,"given":"Josef","family":"Klh\u016ffek","sequence":"first","affiliation":[{"name":"Department of Clinical Pharmacy Tomas Bata Hospital Zlin  Zl\u00edn Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"Vodi\u010dka","sequence":"additional","affiliation":[{"name":"Department of Clinical Pharmacy Tomas Bata Hospital Zlin  Zl\u00edn Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4108-1770","authenticated-orcid":false,"given":"Petr","family":"Pon\u00ed\u017eil","sequence":"additional","affiliation":[{"name":"Department of Physics and Materials Engineering Faculty of Technology Tomas Bata University in Zl\u00edn  Zl\u00edn Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-7220-8436","authenticated-orcid":false,"given":"Ilja","family":"Ry\u0161av\u00fd","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Tomas Bata Hospital Zlin  Zl\u00edn Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Petr","family":"Fojt\u00edk","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Tomas Bata Hospital Zlin  Zl\u00edn Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6737-0554","authenticated-orcid":false,"given":"Vladim\u00edr","family":"Kojeck\u00fd","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Tomas Bata Hospital Zlin  Zl\u00edn Czech Republic"},{"name":"Faculty of Medicine Masaryk University Brno  Brno Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8392-5003","authenticated-orcid":false,"given":"Tom\u00e1\u0161","family":"\u0160\u00e1lek","sequence":"additional","affiliation":[{"name":"Department of Clinical Biochemistry and Pharmacology Tomas Bata Hospital Zlin  Zl\u00edn Czech Republic"},{"name":"Institute of Clinical Biochemistry and Diagnostics Medical Faculty in Hradec Kr\u00e1lov\u00e9 Charles University in Prague  Prague Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,5,10]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1093\/ajh\/hpac048"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.2217\/fca.14.83"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/bcp.14109"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcmm.13205"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.114.05122"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2212270"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamainternmed.2019.7454"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamanetworkopen.2021.23365"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1097\/HJH.0000000000003480"},{"key":"e_1_2_10_11_1","unstructured":"S.Laboratories. \u201cSummary of Product Characteristics: Indapamide \u201d2023[cited 2025\u201002\u201018] https:\/\/www.sukl.cz."},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.7326\/M23-1989"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00228-020-03086-6"},{"key":"e_1_2_10_14_1","first-page":"299","article-title":"Diagnosis and Management of Sodium Disorders: Hyponatremia and Hypernatremia","volume":"91","author":"Braun M. 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