{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T01:03:43Z","timestamp":1790643823627,"version":"4.1.0"},"reference-count":22,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2025,7,20]],"date-time":"2025-07-20T00:00:00Z","timestamp":1752969600000},"content-version":"vor","delay-in-days":19,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82160087"],"award-info":[{"award-number":["82160087"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82370424"],"award-info":[{"award-number":["82370424"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Clinical Hypertension"],"published-print":{"date-parts":[[2025,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p>Masked hypertension (MH), characterized by normal office blood pressure (OBP) but elevated out\u2010of\u2010office readings, carries significant cardiovascular risks comparable to those of sustained hypertension, but remains difficult to detect in clinical practice. This review examines the emerging evidence on screening for MH, highlighting recent findings from the PAMELA study demonstrating the clinical utility of combined vascular and cardiac assessments for the detection of MH. Particularly noteworthy is the observation that patients with both an elevated cardiac\u2010ankle vascular index (CAVI) and left ventricular hypertrophy (LVH) or concentric remodeling had a 2.3\u2010fold increased risk of MH, particularly in men, independent of age and antihypertensive treatment. CAVI offers distinct advantages as a screening parameter due to its independence from blood pressure fluctuations during measurement, its established prognostic value for cardiovascular outcomes, and its high reproducibility in primary care. We propose a stepwise screening approach, prioritizing CAVI assessment in patients with normal OBP but multiple cardiovascular risk factors, followed by echocardiographic assessment in those with elevated CAVI values. This strategy may facilitate earlier detection of MH, allowing timely intervention to reduce cardiovascular morbidity and mortality, although further validation in different age groups and cost\u2010effectiveness analyses are warranted.<\/jats:p>","DOI":"10.1111\/jch.70077","type":"journal-article","created":{"date-parts":[[2025,7,21]],"date-time":"2025-07-21T06:30:55Z","timestamp":1753079455000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Hidden Cardiovascular Risk: Arterial Stiffness and Left Ventricular Remodeling as Potential Indicators of Masked Hypertension"],"prefix":"10.1111","volume":"27","author":[{"given":"Chengjie","family":"Zhu","sequence":"first","affiliation":[{"name":"Intensive Care Unit Yanbian University Hospital  Yanji Jilin P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanna","family":"Lei","sequence":"additional","affiliation":[{"name":"Intensive Care Unit Yanbian University Hospital  Yanji Jilin P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vipin","family":"Kumar","sequence":"additional","affiliation":[{"name":"Department of Cardiology and Hypertension Jilin Provincial Key Laboratory of Stress and Cardiovascular Disease Yanbian University Hospital  Yanji Jilin P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xueling","family":"Yue","sequence":"additional","affiliation":[{"name":"Department of Cardiology and Hypertension Jilin Provincial Key Laboratory of Stress and Cardiovascular Disease Yanbian University Hospital  Yanji Jilin P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qingsong","family":"Cui","sequence":"additional","affiliation":[{"name":"Intensive Care Unit Yanbian University Hospital  Yanji Jilin P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9758-0632","authenticated-orcid":false,"given":"Xian Wu","family":"Cheng","sequence":"additional","affiliation":[{"name":"Department of Cardiology and Hypertension Jilin Provincial Key Laboratory of Stress and Cardiovascular Disease Yanbian University Hospital  Yanji Jilin P.R. China"},{"name":"Key Laboratory of Natural Medicines of the Changbai Mountain Ministry of Education Yanbian University  Yanji Jilin P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,7,20]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/jch.13876"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehae178"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejim.2024.05.033"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tcm.2019.05.003"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(23)00733-X"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/HJH.0000000000003970"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.5551\/jat.3582"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.123.21318"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41440-022-01039-3"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1093\/ajh\/hpaa078"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.120.15859"},{"issue":"5","key":"e_1_2_8_13_1","first-page":"699","article-title":"Prevalence of Masked Hypertension and Its Association With Left Ventricular Hypertrophy in Children and Young Adults With Chronic Kidney Disease: A Systematic Review and Meta\u2010Analysis","volume":"41","author":"Goulas I.","year":"2023","journal-title":"Journal of Hypertension"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ebiom.2024.105107"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1097\/HJH.0b013e32835726a3"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijerph191610038"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms20153664"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ebiom.2024.105107"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1097\/HJH.0000000000003480"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1038\/ajh.2011.75"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.00445.2004"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.3389\/fcvm.2023.1205475"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41371-022-00793-8"}],"container-title":["The Journal of Clinical Hypertension"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jch.70077","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,7,25]],"date-time":"2025-07-25T12:15:08Z","timestamp":1753445708000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jch.70077"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,7]]},"references-count":22,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2025,7]]}},"alternative-id":["10.1111\/jch.70077"],"URL":"https:\/\/doi.org\/10.1111\/jch.70077","archive":["Portico"],"relation":{},"ISSN":["1524-6175","1751-7176"],"issn-type":[{"value":"1524-6175","type":"print"},{"value":"1751-7176","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,7]]},"assertion":[{"value":"2025-04-11","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-05-18","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-07-20","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70077"}}