{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T16:01:03Z","timestamp":1792425663194,"version":"4.5.0"},"reference-count":39,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2025,8,22]],"date-time":"2025-08-22T00:00:00Z","timestamp":1755820800000},"content-version":"vor","delay-in-days":21,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Clinical Hypertension"],"published-print":{"date-parts":[[2025,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p>Primary aldosteronism (PA) independently increases renal impairment risk beyond blood pressure effects. Although hyperaldosteronism is known to mediate renal injury, associations between plasma aldosterone concentration (PAC) and early kidney damage biomarkers such as retinol\u2010binding protein (RBP) and \u03b22\u2010microglobulin (\u03b22\u2010MG) remain insufficiently explored. We investigated the association of PAC with renal function indicators\u2014including RBP, \u03b22\u2010MG, albumin\u2010to\u2010creatinine ratio (ACR), and estimated glomerular filtration rate (eGFR)\u2014comparing matched patients with PA and essential hypertension (EH). In this cross\u2010sectional study, 546 PA patients and 546 propensity score\u2010matched EH patients were assessed. Spearman correlations and multivariate regression analyses assessed PAC\u2010renal marker associations, with interactions tested to determine differences between PA and EH groups. In PA, PAC strongly correlated with lower eGFR (<jats:italic>r<\/jats:italic> = \u22120.597, <jats:italic>p<\/jats:italic> &lt; 0.001) and higher RBP (<jats:italic>r<\/jats:italic> = 0.559), \u03b22\u2010MG (<jats:italic>r<\/jats:italic> = 0.632), and ACR (<jats:italic>r<\/jats:italic> = 0.583), persisting after adjustment. In contrast, EH patients showed only weak correlations between PAC and eGFR (<jats:italic>r<\/jats:italic> = \u22120.204, <jats:italic>p<\/jats:italic> &lt; 0.001), without links with other markers. Interaction analysis confirmed stronger PAC\u2010biomarker associations in PA than EH (all <jats:italic>p<\/jats:italic> &lt; 0.05). This study is the first to demonstrate robust associations between PAC and sensitive early renal damage biomarkers, especially RBP, in PA patients, distinct from matched EH patients. It highlights hyperaldosteronism's unique pathogenic role in renal impairment in PA, suggesting early biomarker monitoring and aldosterone\u2010targeted interventions could reduce chronic kidney disease risk in PA populations.<\/jats:p>","DOI":"10.1111\/jch.70124","type":"journal-article","created":{"date-parts":[[2025,8,22]],"date-time":"2025-08-22T18:43:27Z","timestamp":1755888207000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Association of Plasma Aldosterone Concentration With Early Renal Injury Biomarkers in Primary Aldosteronism: A Propensity\u2010Matched Comparative Study"],"prefix":"10.1111","volume":"27","author":[{"given":"Hai\u2010Long","family":"Liu","sequence":"first","affiliation":[{"name":"Department of Cardiovascular Medicine The 2nd Affiliated Hospital, Jiangxi Medical College, Nanchang University  Jiangxi China"},{"name":"Department of Cardiovascular Medicine Jiu Jiang No.1 People's Hospital  Jiujiang Jiangxi China"},{"name":"Molecular Medicine of Jiangxi Key Laboratory, The Second affiliated Hospital of Nanchang University Nanchang Jiangxi China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qing\u2010Tian","family":"Zeng","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine The 2nd Affiliated Hospital, Jiangxi Medical College, Nanchang University  Jiangxi China"},{"name":"Molecular Medicine of Jiangxi Key Laboratory, The Second affiliated Hospital of Nanchang University Nanchang Jiangxi China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuan\u2010Yuan","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Nephrology and Hemodialysis Medicine Jiu Jiang No.1 People's Hospital  Jiujiang Jiangxi China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiang\u2010Tao","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine 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