{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T14:50:28Z","timestamp":1772203828141,"version":"3.50.1"},"reference-count":37,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2025,9,17]],"date-time":"2025-09-17T00:00:00Z","timestamp":1758067200000},"content-version":"vor","delay-in-days":16,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Clinical Hypertension"],"published-print":{"date-parts":[[2025,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p>This study aimed to evaluate the diagnostic accuracy of 24\u2010hour urinary aldosterone (UALD) for primary aldosteronism (PA) in Northeast China. A total of 423 patients with hypertension were consecutively enrolled. After 1:2 propensity score matching (PSM), 100 patients were classified into the PA group, and 194 patients were classified into the essential hypertension (EH) group. The clinical characteristics and biochemistry measurements were collected and analyzed. A receiver operating characteristic (ROC) curve was generated, and the area under the curve (AUC) was calculated to determine optimal diagnostic thresholds. No significant difference in age was observed between the groups (PA: 53.4 \u00b1 11.3 years vs. EH: 52.8 \u00b1 11.3 years, <jats:italic>p<\/jats:italic> &gt; 0.05). The median 24\u2010hour UALD was significantly greater in the PA group (6.4 [3.7, 13.9] \u00b5g\/24\u00a0h vs. 4.8 [2.5, 7.8] \u00b5g\/24\u00a0h, <jats:italic>p<\/jats:italic> &lt; 0.05), with levels declining with age in both cohorts. The optimal UALD cutoff value was 11.4\u00a0\u00b5g\/24\u00a0h (AUC = 0.652; Youden index = 0.257). For patients over 55 years, the 24\u2010hour urinary aldosterone\u2010to\u2010creatinine ratio (UACR) showed superior diagnostic performance, with an optimal cutoff of 0.8\u00a0\u00b5g\/mmol\/L (AUC = 0.695). 24\u2010Hour UALD was a promising diagnostic marker for PA in North China, whereas 24\u2010hour UACR might increase accuracy in older populations. However, further studies are needed to validate these findings.<\/jats:p>","DOI":"10.1111\/jch.70130","type":"journal-article","created":{"date-parts":[[2025,9,17]],"date-time":"2025-09-17T07:15:41Z","timestamp":1758093341000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Diagnostic Accuracy of 24\u2010Hour Urinary Aldosterone for Primary Aldosteronism in Northeast China"],"prefix":"10.1111","volume":"27","author":[{"given":"Kaiwen","family":"Sun","sequence":"first","affiliation":[{"name":"Department of Cardiology First Affiliated Hospital of Dalian Medical University  Dalian Liaoning China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Minghui","family":"Gong","sequence":"additional","affiliation":[{"name":"Department of Cardiology First Affiliated Hospital of Dalian Medical University  Dalian Liaoning China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yang","family":"Yu","sequence":"additional","affiliation":[{"name":"Department of Cardiology First Affiliated Hospital of Dalian Medical University  Dalian Liaoning China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Minghui","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Cardiology First Affiliated Hospital of Dalian Medical University  Dalian Liaoning China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yinong","family":"Jiang","sequence":"additional","affiliation":[{"name":"Department of Cardiology First Affiliated Hospital of Dalian Medical University  Dalian Liaoning China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ying","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Cardiology First Affiliated Hospital of Dalian Medical University  Dalian Liaoning 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