{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T21:29:34Z","timestamp":1778621374421,"version":"3.51.4"},"reference-count":31,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2025,9,22]],"date-time":"2025-09-22T00:00:00Z","timestamp":1758499200000},"content-version":"vor","delay-in-days":21,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Clinical Hypertension"],"published-print":{"date-parts":[[2025,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p>This study aimed to compare systolic blood pressure (SBP) time in target range (TTR), long\u2010term blood pressure (BP) variability (BPV), and BP control across age groups (18\u201345, 46\u201364, 65\u201379, \u226580 years) in patients with primary hypertension treated with amlodipine\u2010based antihypertensive therapy for \u226512 months. Data were obtained from adult patients enrolled in the China Hypertension Center who received amlodipine\u2010based antihypertensive therapy. Demographics, BP measurements, and laboratory results were recorded. Baseline characteristics, SBP TTR, long\u2010term BPV, and BP control were compared among age groups. A total of 36\u00a0153 patients were included: 2681 in the 18\u201345 group, 14\u00a0300 in the 46\u201364 group, 15\u00a0595 in the 65\u201379 group, and 3577 in the \u2265\u00a080 group. Younger and middle\u2010aged patients demonstrated better indicator improvements. SBP TTR declined with age (82.52%\u00a0\u00b1\u00a019.68%, 81.98%\u00a0\u00b1\u00a020.69%, 79.10%\u00a0\u00b1\u00a022.96%, and 78.33%\u00a0\u00b1\u00a023.50%, respectively; <jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.001). BP control also declined with age (84.04%, 83.20%, 80.44%, and 79.59%, respectively; <jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.001). BPV increased with age, though not significantly (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.051). During follow\u2010up, SBP TTR and BP control improved, while BPV declined, with most changes reaching statistical significance. Across all age groups, SBP TTR remained above 78% throughout follow\u2010up. Long\u2010term continuous use of amlodipine is beneficial for achieving improved BP control, enhanced TTR, and reduced BPV.<\/jats:p>","DOI":"10.1111\/jch.70151","type":"journal-article","created":{"date-parts":[[2025,9,23]],"date-time":"2025-09-23T03:26:09Z","timestamp":1758597969000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Amlodipine\u2010Based Therapy and Its Effect on Time in Target Range and Long\u2010Term Blood Pressure Variability Across Age Groups in Chinese Patients With Primary Hypertension: A Retrospective Study"],"prefix":"10.1111","volume":"27","author":[{"given":"Jinghan","family":"Yang","sequence":"first","affiliation":[{"name":"Department of Cardiology, The First Affiliated Hospital Fujian Medical University  Fuzhou China"},{"name":"The Higher Educational Key Laboratory For Cardiovascular Disease of Fujian Province; Clinical Research Center for Metabolic Heart Disease of Fujian Province; The First Affiliated Hospital Fujian Medical University  Fuzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shuling","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Cardiology, The First Affiliated Hospital Fujian Medical University  Fuzhou China"},{"name":"The Higher Educational Key Laboratory For Cardiovascular Disease of Fujian Province; Clinical Research Center for Metabolic Heart Disease of Fujian Province; The First Affiliated Hospital Fujian Medical University  Fuzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dajun","family":"Chai","sequence":"additional","affiliation":[{"name":"Department of Cardiology, The First Affiliated Hospital Fujian Medical University  Fuzhou China"},{"name":"The Higher Educational Key Laboratory For Cardiovascular Disease of Fujian Province; Clinical Research Center for Metabolic Heart Disease of Fujian Province; The First Affiliated Hospital Fujian Medical University  Fuzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Feng","family":"Peng","sequence":"additional","affiliation":[{"name":"Department of Cardiology, The First Affiliated Hospital Fujian Medical University  Fuzhou China"},{"name":"The Higher Educational Key Laboratory For Cardiovascular Disease of Fujian Province; Clinical Research Center for Metabolic Heart Disease of Fujian Province; The First Affiliated Hospital Fujian Medical University  Fuzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0378-2813","authenticated-orcid":false,"given":"Ningling","family":"Sun","sequence":"additional","affiliation":[{"name":"Peking University People's Hospital  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1035-2993","authenticated-orcid":false,"given":"Jinxiu","family":"Lin","sequence":"additional","affiliation":[{"name":"Department of Cardiology, The First Affiliated Hospital Fujian Medical University  Fuzhou China"},{"name":"The Higher Educational Key Laboratory For Cardiovascular Disease of Fujian Province; Clinical Research Center for Metabolic Heart Disease of Fujian Province; The First Affiliated Hospital Fujian Medical University  Fuzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,9,22]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehae178"},{"key":"e_1_2_12_3_1","unstructured":"WHO.Global Report on Hypertension: The Race Against a Silent Killer(WHO 2023)."},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41569-022-00829-z"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/HJH.0000000000002698"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamainternmed.2016.0190"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/HJH.0000000000003480"},{"issue":"7","key":"e_1_2_12_8_1","first-page":"603","article-title":"Chinese Guidelines for Prevention and Treatment of Hypertension (2024 revision)","volume":"32","author":"Committee C.","year":"2024","journal-title":"Chinese Journal of Hypertension"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/00004872-200204000-00037"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.jhh.1001511"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1097\/HJH.0000000000003819"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehad814"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.1097\/HJH.0000000000003994"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.1097\/HJH.0000000000003363"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.117.032380"},{"key":"e_1_2_12_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/jch.14709"},{"key":"e_1_2_12_17_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehae023"},{"key":"e_1_2_12_18_1","doi-asserted-by":"publisher","DOI":"10.2217\/cer-2017-0063"},{"key":"e_1_2_12_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jash.2014.02.004"},{"key":"e_1_2_12_20_1","article-title":"2025 AHA\/ACC\/AANP\/AAPA\/ABC\/ACCP\/ACPM\/AGS\/AMA\/ASPC\/NMA\/PCNA\/SGIM Guideline for the Prevention, Detection, Evaluation and Management of High Blood Pressure in Adults: A Report of the American College of Cardiology\/American Heart Association Joint Committee on Clinical Practice Guidelines","author":"Jones D. 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