{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T13:44:53Z","timestamp":1792158293732,"version":"4.4.0"},"reference-count":20,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T00:00:00Z","timestamp":1761609600000},"content-version":"vor","delay-in-days":27,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Clinical Hypertension"],"published-print":{"date-parts":[[2025,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Perirenal adipose tissue (PRAT) contributes to the maintenance of elevated blood pressure through afferent nerves and serves as an important peripheral, modifiable target for hypertension management. This single\u2010center, prospective pilot trial assessed the feasibility and safety of a novel focused power ultrasound device for perirenal adipose tissue modification (PRATM) therapy in essential hypertension. Twenty patients (mean age 47.5\u00a0\u00b1\u00a011.0 years, 85% male) with office systolic blood pressure (OSBP) 140\u2013180\u00a0mmHg or diastolic blood pressure (ODBP) \u226590\u00a0mmHg were enrolled. All underwent PRATM therapy and were followed for 3 months. The primary endpoint was all\u2010cause mortality or device\u2010related adverse events (AEs). Four patients experienced transient mild lumbar pain, and one had mild skin redness, all resolving spontaneously. No serious AEs or clinically significant abnormalities were observed. OSBP decreased by 14.6\u00a0mmHg at 1 month and 18.2\u00a0mmHg at 3 months; ODBP decreased by 5.8\u00a0mmHg and 2.8\u00a0mmHg, respectively. For the 24\u2010hour ambulatory blood pressure monitoring (ABPM), 24\u2010hour ambulatory SBP decreased by 3.6\u00a0mmHg (95% CI: \u20103.6\u201010.8\u00a0mmHg) and 24\u2010hour ambulatory DBP decreased by 2.2\u00a0mmHg (95% CI: \u22122.7\u20137.0\u00a0mmHg) at 1 month. At 3 months, 24\u2010hour ambulatory SBP decreased by 2.8\u00a0mmHg (95% CI: \u22125.4\u201311.0\u00a0mmHg) and 24\u2010hour ambulatory DBP decreased by 1.7\u00a0mmHg (95% CI: \u22124.0\u20107.3\u00a0mmHg). PRATM shows preliminary feasibility and safety, but larger, randomized trials are needed for definitive efficacy and long\u2010term safety validation.<\/jats:p>","DOI":"10.1111\/jch.70166","type":"journal-article","created":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T14:50:00Z","timestamp":1761663000000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Focused Power Ultrasound Mediated Inferior Perirenal Adipose Tissue Modification Therapy for Essential Hypertension: A Pilot Study"],"prefix":"10.1111","volume":"27","author":[{"given":"Yang","family":"Hua","sequence":"first","affiliation":[{"name":"Department of Cardiology The First Affiliated Hospital with Nanjing Medical University  Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meng\u2010Huan","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Cardiology The First Affiliated Hospital with Nanjing 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