{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T01:51:20Z","timestamp":1789523480207,"version":"build-2803163510"},"reference-count":142,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2025,11,19]],"date-time":"2025-11-19T00:00:00Z","timestamp":1763510400000},"content-version":"vor","delay-in-days":18,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Clinical Hypertension"],"published-print":{"date-parts":[[2025,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Cardiovascular diseases (CVDs) remain the leading cause of morbidity and mortality globally. Emerging evidence suggests that inflammation plays a pivotal role in the pathogenesis of atherosclerosis and subsequent cardiovascular events. Traditional treatments primarily focus on lipid\u2010lowering and antithrombotic strategies; however, these approaches do not fully address the inflammatory component of CVD. Recent advancements have highlighted the potential of targeted anti\u2010inflammatory therapies in mitigating cardiovascular risk. This review explores the efficacy and safety of these novel therapeutic agents. Interleukin (IL)\u20101\u03b2 inhibitors, such as canakinumab, have shown promising results in reducing recurrent cardiovascular events in post\u2010myocardial infarction patients. By directly modulating inflammatory pathways, canakinumab significantly lowered the incidence of major adverse cardiovascular events (MACE) independent of lipid levels. Similarly, colchicine, an ancient anti\u2010inflammatory drug, has gained renewed interest due to its efficacy in reducing cardiovascular events in patients with chronic coronary disease and recent myocardial infarction. Furthermore, emerging therapies targeting other inflammatory mediators like IL\u20106 and tumor necrosis factor\u2010\u03b1 are under investigation, offering additional avenues for intervention. Despite these advancements, challenges such as identifying appropriate patient populations, long\u2010term safety, and cost\u2010effectiveness remain. Ongoing research aims to refine these therapies, ensuring a balance between risk reduction and adverse effects. In conclusion, targeted anti\u2010inflammatory therapy represents a promising adjunct to traditional CVD treatments, potentially revolutionizing the management of cardiovascular events. Future studies are essential to optimize these strategies and fully integrate them into clinical practice, enhancing outcomes for patients with CVD.<\/jats:p>","DOI":"10.1111\/jch.70172","type":"journal-article","created":{"date-parts":[[2025,11,19]],"date-time":"2025-11-19T11:41:10Z","timestamp":1763552470000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Targeted Anti\u2010Inflammatory Therapy in Cardiovascular Events: Challenges and Opportunities"],"prefix":"10.1111","volume":"27","author":[{"given":"Li","family":"Feng","sequence":"first","affiliation":[{"name":"Jiyang College Zhejiang A&amp;F University Zhuji Zhejiang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ling","family":"Wang","sequence":"additional","affiliation":[{"name":"Shigatse Branch Xinqiao Hospital, Third Military Medical University Shigatse China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaorong","family":"Yan","sequence":"additional","affiliation":[{"name":"Shigatse Branch Xinqiao Hospital, Third Military Medical University Shigatse China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tianyi","family":"Ma","sequence":"additional","affiliation":[{"name":"Shigatse Branch Xinqiao Hospital, Third Military Medical University Shigatse China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,11,19]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cpcardiol.2023.102182"},{"issue":"2","key":"e_1_2_11_3_1","first-page":"161","article-title":"Cardiovascular Disease and Antiphospholipid Syndrome: How to Predict and How to Treat","volume":"131","author":"Calcaterra I.","year":"2021","journal-title":"Polish Archives of Internal Medicine"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1515\/hmbci\u20102022\u20100020"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1080\/13543784.2021.1985463"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2024.116587"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41419\u2010023\u201006206\u2010z"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jjcc.2015.02.002"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.addr.2020.07.019"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrcardio.2016.185"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.3390\/cells10040951"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1093\/cvr\/cvaa211"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.3390\/biomedicines12030701"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms24032483"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2021.06.037"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.2217\/fca\u20102021\u20100027"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.121.056171"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.21037\/atm.2019.02.34"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2022.1046406"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehz425"},{"issue":"11","key":"e_1_2_11_21_1","first-page":"e563","article-title":"ACC\/AHA Guideline on the Primary Prevention of Cardiovascular Disease: Executive Summary: A Report of the American College of Cardiology\/American Heart Association Task Force on Clinical Practice Guidelines","volume":"140","author":"Arnett D. K.","year":"2019","journal-title":"Circulation"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.117.031855"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.118.314576"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(12)60367-5"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12872\u2010018\u20100870\u20109"},{"key":"e_1_2_11_26_1","doi-asserted-by":"publisher","DOI":"10.3389\/fcvm.2020.631398"},{"key":"e_1_2_11_27_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa042000"},{"key":"e_1_2_11_28_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.115.018381"},{"key":"e_1_2_11_29_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.118.313129"},{"key":"e_1_2_11_30_1","doi-asserted-by":"publisher","DOI":"10.3390\/pharmaceutics13010064"},{"key":"e_1_2_11_31_1","doi-asserted-by":"publisher","DOI":"10.4244\/EIJ\u2010D\u201023\u201000606"},{"key":"e_1_2_11_32_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41392\u2010022\u201000955\u20107"},{"key":"e_1_2_11_33_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11886\u2010020\u201001358\u20102"},{"key":"e_1_2_11_34_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2021372"},{"key":"e_1_2_11_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2017.09.028"},{"key":"e_1_2_11_36_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.ATV.0000064374.15232.C3"},{"key":"e_1_2_11_37_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.ATV.16.8.1000"},{"key":"e_1_2_11_38_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.ATV.20.11.2394"},{"key":"e_1_2_11_39_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1701719"},{"key":"e_1_2_11_40_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.aag1381"},{"key":"e_1_2_11_41_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF03261881"},{"issue":"3","key":"e_1_2_11_42_1","first-page":"394","article-title":"Interleukin\u20101 Activation of Vascular Endothelium. Effects on Procoagulant Activity and Leukocyte Adhesion","volume":"121","author":"Bevilacqua M. P.","year":"1985","journal-title":"American Journal of Pathology"},{"key":"e_1_2_11_43_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI113346"},{"key":"e_1_2_11_44_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2020.589654"},{"key":"e_1_2_11_45_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI67526"},{"key":"e_1_2_11_46_1","doi-asserted-by":"publisher","DOI":"10.1161\/circ.104.suppl_1.I\u2010308"},{"key":"e_1_2_11_47_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehz008"},{"key":"e_1_2_11_48_1","doi-asserted-by":"publisher","DOI":"10.1111\/imr.12606"},{"key":"e_1_2_11_49_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.atherosclerosis.2018.07.007"},{"key":"e_1_2_11_50_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yexmp.2018.01.008"},{"key":"e_1_2_11_51_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749\u20106632.2009.04645.x"},{"key":"e_1_2_11_52_1","doi-asserted-by":"publisher","DOI":"10.1111\/bph.13818"},{"key":"e_1_2_11_53_1","doi-asserted-by":"publisher","DOI":"10.1038\/cdd.2011.93"},{"key":"e_1_2_11_54_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.atherosclerosis.2004.11.016"},{"key":"e_1_2_11_55_1","doi-asserted-by":"publisher","DOI":"10.1093\/cvr\/cvn193"},{"key":"e_1_2_11_56_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrcardio.2015.5"},{"key":"e_1_2_11_57_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.22809"},{"key":"e_1_2_11_58_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2013.06.019"},{"key":"e_1_2_11_59_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.112.120410"},{"key":"e_1_2_11_60_1","doi-asserted-by":"publisher","DOI":"10.1002\/acr.22166"},{"key":"e_1_2_11_61_1","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/ket454"},{"key":"e_1_2_11_62_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.39039"},{"key":"e_1_2_11_63_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140\u20106736(12)60110\u2010X"},{"key":"e_1_2_11_64_1","doi-asserted-by":"publisher","DOI":"10.2217\/imt\u20102017\u20100075"},{"key":"e_1_2_11_65_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40744\u2010018\u20100102\u2010x"},{"key":"e_1_2_11_66_1","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis\u20102015\u2010207872"},{"key":"e_1_2_11_67_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.40084"},{"key":"e_1_2_11_68_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.semarthrit.2014.07.006"},{"issue":"1","key":"e_1_2_11_69_1","first-page":"81","article-title":"Canakinumab, a Fully\u2010Human mAb Against IL\u20101beta for the Potential Treatment of Inflammatory Disorders","volume":"11","author":"Church L. D.","year":"2009","journal-title":"Current Opinion in Molecular Therapeutics"},{"key":"e_1_2_11_70_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjmed.2018.10.013"},{"key":"e_1_2_11_71_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140\u20106736(17)32814\u20103"},{"key":"e_1_2_11_72_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41591\u2010018\u20100124\u20105"},{"key":"e_1_2_11_73_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2018.12.083"},{"key":"e_1_2_11_74_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2013.04.066"},{"key":"e_1_2_11_75_1","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/kead625"},{"key":"e_1_2_11_76_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.semarthrit.2008.08.006"},{"key":"e_1_2_11_77_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature04516"},{"key":"e_1_2_11_78_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI118147"},{"key":"e_1_2_11_79_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI116759"},{"key":"e_1_2_11_80_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11926\u2010002\u20100073\u20102"},{"key":"e_1_2_11_81_1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers15205031"},{"key":"e_1_2_11_82_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjmed.2021.01.019"},{"key":"e_1_2_11_83_1","doi-asserted-by":"publisher","DOI":"10.1161\/ATVBAHA.124.319851"},{"key":"e_1_2_11_84_1","doi-asserted-by":"publisher","DOI":"10.1155\/2024\/8646351"},{"key":"e_1_2_11_85_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.acvd.2020.04.007"},{"key":"e_1_2_11_86_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.121.058233"},{"key":"e_1_2_11_87_1","first-page":"10","article-title":"Role of Colchicine in Cardiovascular Disorders","author":"Moras E.","year":"2024","journal-title":"Cardiology in Review"},{"key":"e_1_2_11_88_1","doi-asserted-by":"publisher","DOI":"10.1016\/0008\u20108749(89)90095\u20106"},{"key":"e_1_2_11_89_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI114498"},{"key":"e_1_2_11_90_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrd.2018.45"},{"key":"e_1_2_11_91_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.ATV.17.12.3399"},{"key":"e_1_2_11_92_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1074\u20107613(00)80334\u20109"},{"key":"e_1_2_11_93_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpcell.00235.2017"},{"key":"e_1_2_11_94_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehw171"},{"key":"e_1_2_11_95_1","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.119.015628"},{"key":"e_1_2_11_96_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCINTERVENTIONS.119.008717"},{"key":"e_1_2_11_97_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2013.03.003"},{"key":"e_1_2_11_98_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.286.17.2107"},{"key":"e_1_2_11_99_1","doi-asserted-by":"publisher","DOI":"10.1191\/0961203303lu412oa"},{"key":"e_1_2_11_100_1","doi-asserted-by":"publisher","DOI":"10.1038\/nri2156"},{"key":"e_1_2_11_101_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.ATV.17.10.1954"},{"key":"e_1_2_11_102_1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/cit489"},{"key":"e_1_2_11_103_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2018.02.024"},{"key":"e_1_2_11_104_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.imbio.2013.06.005"},{"key":"e_1_2_11_105_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598\u2010019\u201051691\u2010y"},{"key":"e_1_2_11_106_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehac094"},{"key":"e_1_2_11_107_1","doi-asserted-by":"publisher","DOI":"10.1155\/2020\/4293206"},{"key":"e_1_2_11_108_1","doi-asserted-by":"publisher","DOI":"10.1159\/000490866"},{"key":"e_1_2_11_109_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1301676"},{"key":"e_1_2_11_110_1","doi-asserted-by":"publisher","DOI":"10.1159\/000481846"},{"key":"e_1_2_11_111_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11999\u2010016\u20104866\u20104"},{"key":"e_1_2_11_112_1","doi-asserted-by":"publisher","DOI":"10.1080\/14728222.2020.1795831"},{"key":"e_1_2_11_113_1","doi-asserted-by":"publisher","DOI":"10.3390\/antiox12071396"},{"key":"e_1_2_11_114_1","doi-asserted-by":"publisher","DOI":"10.1111\/bph.13429"},{"key":"e_1_2_11_115_1","doi-asserted-by":"publisher","DOI":"10.3390\/biology11020224"},{"key":"e_1_2_11_116_1","doi-asserted-by":"publisher","DOI":"10.1160\/TH14-11-0947"},{"key":"e_1_2_11_117_1","doi-asserted-by":"publisher","DOI":"10.1089\/ars.2020.8107"},{"key":"e_1_2_11_118_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12967\u2010022\u201003631\u20100"},{"key":"e_1_2_11_119_1","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.118.12109"},{"key":"e_1_2_11_120_1","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.116.003698"},{"key":"e_1_2_11_121_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tim.2022.08.003"},{"key":"e_1_2_11_122_1","doi-asserted-by":"publisher","DOI":"10.1080\/19490976.2021.1897212"},{"key":"e_1_2_11_123_1","doi-asserted-by":"publisher","DOI":"10.1194\/jlr.R088989"},{"key":"e_1_2_11_124_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12010\u2010008\u20108187\u20102"},{"key":"e_1_2_11_125_1","doi-asserted-by":"publisher","DOI":"10.1080\/1745039X.2011.617546"},{"key":"e_1_2_11_126_1","doi-asserted-by":"publisher","DOI":"10.1038\/nri1004"},{"key":"e_1_2_11_127_1","doi-asserted-by":"publisher","DOI":"10.3390\/life12121986"},{"key":"e_1_2_11_128_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2016.02.011"},{"key":"e_1_2_11_129_1","doi-asserted-by":"publisher","DOI":"10.1210\/clinem\/dgac210"},{"key":"e_1_2_11_130_1","doi-asserted-by":"publisher","DOI":"10.1111\/1440\u20101681.13727"},{"key":"e_1_2_11_131_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.116.309006"},{"key":"e_1_2_11_132_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrd3444"},{"key":"e_1_2_11_133_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41573\u2010021\u201000198\u20101"},{"key":"e_1_2_11_134_1","doi-asserted-by":"publisher","DOI":"10.1093\/ehjcvp\/pvaf058"},{"key":"e_1_2_11_135_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehad486"},{"key":"e_1_2_11_136_1","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.117.008024"},{"key":"e_1_2_11_137_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phrs.2022.106157"},{"key":"e_1_2_11_138_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002\u20109149(02)02234\u20108"},{"key":"e_1_2_11_139_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2008.11.013"},{"issue":"4","key":"e_1_2_11_140_1","article-title":"Cardiovascular Risk of Nonsteroidal Anti\u2010Inflammatory Drugs: An Under\u2010Recognized Public Health Issue","volume":"9","author":"Varga Z.","year":"2017","journal-title":"Cureus"},{"key":"e_1_2_11_141_1","doi-asserted-by":"publisher","DOI":"10.1186\/1747\u20105341\u20103\u201020"},{"key":"e_1_2_11_142_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.atherosclerosis.2015.04.783"},{"key":"e_1_2_11_143_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI88884"}],"container-title":["The Journal of Clinical Hypertension"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jch.70172","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,26]],"date-time":"2025-11-26T11:45:28Z","timestamp":1764157528000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jch.70172"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11]]},"references-count":142,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2025,11]]}},"alternative-id":["10.1111\/jch.70172"],"URL":"https:\/\/doi.org\/10.1111\/jch.70172","archive":["Portico"],"relation":{},"ISSN":["1524-6175","1751-7176"],"issn-type":[{"value":"1524-6175","type":"print"},{"value":"1751-7176","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,11]]},"assertion":[{"value":"2025-07-15","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-10-11","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-11-19","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70172"}}