{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,26]],"date-time":"2025-11-26T11:49:47Z","timestamp":1764157787770,"version":"3.46.0"},"reference-count":39,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2025,11,8]],"date-time":"2025-11-08T00:00:00Z","timestamp":1762560000000},"content-version":"vor","delay-in-days":7,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82170449"],"award-info":[{"award-number":["82170449"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Clinical Hypertension"],"published-print":{"date-parts":[[2025,11]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>This study aimed to compare the blood pressure\u2013lowering efficacy and safety of different renal denervation (RDN) techniques. We systematically searched PubMed, Ovid, and Embase up to September 4, 2025. The primary outcome was the change in 24\u00a0h ambulatory systolic blood pressure from baseline to the end of follow\u2010up. Secondary outcomes included changes in 24\u00a0h ambulatory diastolic blood pressure and the incidence of major adverse events. Two reviewers independently conducted study screening, data extraction, and risk of bias assessment. A network meta\u2010analysis, along with sensitivity and subgroup analyses, was performed. Our analysis indicated that both radiofrequency RDN of the main renal artery and branches (RFB\u2010RDN) and ultrasound RDN (US\u2010RDN) were associated with significant reductions in 24\u00a0h ambulatory blood pressure, with comparable efficacy between the two approaches, whereas radiofrequency RDN of the main renal artery (RFM\u2010RDN) and alcohol\u2010mediated RDN (ALC\u2010RDN) showed limited efficacy. Compared with sham, US\u2010RDN and RFM\u2010RDN showed trends toward fewer adverse events, whereas RFB\u2010RDN and ALC\u2010RDN exhibited numerically higher risks; however, these differences did not reach statistical significance. Subgroup analyses suggested that hypertension subtype, ethnicity, and baseline blood pressure may influence treatment effects, particularly for RFB\u2010RDN.<\/jats:p>","DOI":"10.1111\/jch.70178","type":"journal-article","created":{"date-parts":[[2025,11,8]],"date-time":"2025-11-08T18:24:59Z","timestamp":1762626299000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["The Efficacy and Safety of Different Ways of Renal Denervation for Hypertension: A Systematic Review and Network Meta\u2010Analysis"],"prefix":"10.1111","volume":"27","author":[{"ORCID":"https:\/\/orcid.org\/0009-0005-1455-7947","authenticated-orcid":false,"given":"Qinxian","family":"Tu","sequence":"first","affiliation":[{"name":"Department of Cardiology National Center for Cardiovascular Diseases Fuwai Hospital Peking Union Medical College  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yizhuo","family":"Duan","sequence":"additional","affiliation":[{"name":"Department of Cardiology National Center for Cardiovascular Diseases Fuwai Hospital Peking Union Medical College  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jingru","family":"Shan","sequence":"additional","affiliation":[{"name":"Zhongshan School of Medicine Sun Yat\u2010sen University  Guangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiongjing","family":"Jiang","sequence":"additional","affiliation":[{"name":"Department of Cardiology National Center for Cardiovascular Diseases Fuwai Hospital Peking Union Medical College  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hui","family":"Dong","sequence":"additional","affiliation":[{"name":"Department of Cardiology National Center for Cardiovascular Diseases Fuwai Hospital Peking Union Medical College  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yubao","family":"Zou","sequence":"additional","affiliation":[{"name":"Department of Cardiology National Center for Cardiovascular Diseases Fuwai Hospital Peking Union Medical College  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,11,8]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(21)01330-1"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(20)30752-2"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(21)00590-0"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvs.2014.05.038"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehu209"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(09)60566-3"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.n71"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2025.05.007"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.l4898"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(21)00788-1"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2023.0713"},{"issue":"4","key":"e_1_2_12_13_1","first-page":"461","article-title":"The REDUCE HTN: REINFORCE: Randomized, Sham\u2010Controlled Trial of Bipolar Radiofrequency Renal Denervation for the Treatment of Hypertension","volume":"13","author":"Weber M. 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