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A total of 236 hypertensive patients who underwent cardiovascular magnetic resonance (CMR) and blood routine examinations at two medical centers in China were included. Thirty healthy volunteers were included as the control group. Compared with the low systemic inflammatory response index (SIRI) group, patients in the high SIRI group exhibited greater EAT volume, higher Native T1 value, and increased extracellular volume (ECV) (all\n                    <jats:italic>p<\/jats:italic>\n                    &lt; 0.01). Additionally, significant differences were observed between the two groups in cardiac MRI parameters (all\n                    <jats:italic>p<\/jats:italic>\n                    &lt; 0.001). Hypertensive patients had a significantly higher SIRI than healthy controls (\n                    <jats:italic>p<\/jats:italic>\n                    &lt; 0.001). Binary logistic regression analysis indicated that SIRI and indexed EAT volume were independently associated with high ECV value (SIRI:\n                    <jats:italic>p<\/jats:italic>\n                    &lt; 0.001; indexed EAT volume:\n                    <jats:italic>p<\/jats:italic>\n                    &lt; 0.001), with results remaining stable after adjusting for confounding factors. Furthermore, mediation analysis showed that even after adjusting for confounding factors, EAT continued to play a role in SIRI\u2010mediated changes in ECV (indirect effect: 0.1773 [95% CI 0.0173\u20130.3147]). HTN may contribute to the increase in systemic inflammatory severity. The relationship between the degree of myocardial fibrosis and the severity of systemic inflammatory status in patients with early HTN is mediated by EAT. Early mitigation of systemic inflammatory status in patients with early\u2010stage HTN can reduce the adverse effects of EAT, thereby alleviating myocardial fibrosis and strain impairment.\n                  <\/jats:p>","DOI":"10.1111\/jch.70182","type":"journal-article","created":{"date-parts":[[2025,11,15]],"date-time":"2025-11-15T02:09:17Z","timestamp":1763172557000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["The Relationship Between Myocardial Fibrosis in Hypertensive Patients With Preserved Ejection Fraction and the Severity of Systemic Inflammatory Status Is Mediated by Epicardial Adipose Tissue: A Multicenter Cohort Study"],"prefix":"10.1111","volume":"27","author":[{"given":"Wanting","family":"Wang","sequence":"first","affiliation":[{"name":"Shandong First Medical University (Shandong Academy of Medical Sciences)  Jinan Shandong China"},{"name":"Key Laboratory of Endocrine Glucose &amp; Lipids Metabolism and Brain Aging Ministry of Education; Department of Endocrinology Shandong Provincial Hospital Affiliated to Shandong First Medical University  Jinan Shandong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Runze","family":"Zhu","sequence":"additional","affiliation":[{"name":"Key Laboratory of Endocrine Glucose &amp; Lipids Metabolism and Brain Aging Ministry of Education; Department of Endocrinology Shandong Provincial Hospital Affiliated to Shandong First Medical University  Jinan Shandong China"},{"name":"School of Radiology Shandong First Medical University &amp; Shandong Academy of Medical Sciences  Taian Shandong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenxian","family":"Wang","sequence":"additional","affiliation":[{"name":"Key Laboratory of Endocrine Glucose &amp; Lipids Metabolism and Brain Aging Ministry of Education; Department of Endocrinology Shandong Provincial Hospital Affiliated to Shandong First Medical University  Jinan Shandong China"},{"name":"School of Radiology Shandong First Medical University &amp; Shandong Academy of Medical Sciences  Taian Shandong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Gao","sequence":"additional","affiliation":[{"name":"Key Laboratory of Endocrine Glucose &amp; Lipids Metabolism and Brain Aging Ministry of Education; Department of Endocrinology Shandong Provincial Hospital Affiliated to Shandong First Medical University  Jinan Shandong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jie","family":"Liu","sequence":"additional","affiliation":[{"name":"Key Laboratory of Endocrine Glucose &amp; Lipids Metabolism and Brain Aging Ministry of Education; Department of Endocrinology Shandong Provincial Hospital Affiliated to Shandong First Medical University  Jinan Shandong China"},{"name":"School of Medical Imaging Binzhou Medical University  Yantai Shandong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liang","family":"Wu","sequence":"additional","affiliation":[{"name":"Key Laboratory of Endocrine Glucose &amp; Lipids Metabolism and Brain Aging Ministry of Education; Department of Endocrinology Shandong Provincial Hospital Affiliated to Shandong First Medical University  Jinan Shandong China"},{"name":"School of Medical Imaging Binzhou Medical University  Yantai Shandong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ximing","family":"Wang","sequence":"additional","affiliation":[{"name":"Shandong First Medical University (Shandong Academy of Medical Sciences)  Jinan Shandong China"},{"name":"Key Laboratory of Endocrine Glucose &amp; Lipids Metabolism and Brain Aging Ministry of Education; Department of Endocrinology Shandong Provincial Hospital Affiliated to Shandong First Medical University  Jinan Shandong China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,11,14]]},"reference":[{"key":"e_1_2_13_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jchf.2017.04.012"},{"key":"e_1_2_13_3_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm12072606"},{"key":"e_1_2_13_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10741\u2010013\u20109405\u20108"},{"key":"e_1_2_13_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.crad.2016.02.013"},{"key":"e_1_2_13_6_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/suw022"},{"key":"e_1_2_13_7_1","doi-asserted-by":"publisher","DOI":"10.1055\/s\u20102008\u20101062724"},{"key":"e_1_2_13_8_1","doi-asserted-by":"publisher","DOI":"10.1515\/jbcpp\u20102022\u20100230"},{"key":"e_1_2_13_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biocel.2011.09.006"},{"key":"e_1_2_13_10_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurjpc\/zwaf028"},{"key":"e_1_2_13_11_1","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.124.036789"},{"key":"e_1_2_13_12_1","doi-asserted-by":"publisher","DOI":"10.2147\/JIR.S378309"},{"key":"e_1_2_13_13_1","doi-asserted-by":"publisher","DOI":"10.1097\/HJH.0b013e3282170ada"},{"key":"e_1_2_13_14_1","doi-asserted-by":"crossref","unstructured":"J. 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