{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,26]],"date-time":"2025-11-26T11:49:47Z","timestamp":1764157787479,"version":"3.46.0"},"reference-count":41,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2025,11,26]],"date-time":"2025-11-26T00:00:00Z","timestamp":1764115200000},"content-version":"vor","delay-in-days":25,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Clinical Hypertension"],"published-print":{"date-parts":[[2025,11]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    This retrospective cohort study assessed the effect of COVID\u201019 infection on blood pressure variability (BPV) and cardiovascular outcomes in hypertensive patients using 24\u2010h ambulatory blood pressure monitoring and structural equation modeling (SEM). Among 318 patients followed for 2 years, those with infection and poor prognosis showed the most abnormal hemodynamic patterns, including markedly elevated nocturnal SBP load (70.0%\u00a0vs. 50.1%), higher ARVDBP (9.8%\u00a0vs. 8.2%), wider pulse pressure (60.9\u00a0mmHg), and lower time in target range (30.9%\u00a0vs. 74.7%,\n                    <jats:italic>p\u00a0<\/jats:italic>\n                    &lt;\u00a00.001). Cox regression identified infection status, nocturnal BP load, and BP variability as major risk factors, while multivariate models confirmed 11 independent predictors. Neither diabetes nor antihypertensive medication class modified these associations. SEM demonstrated that infection influenced prognosis indirectly through elevated nighttime BP level, load, and variability (indirect effect\n                    <jats:italic>\u03b2<\/jats:italic>\n                    \u00a0=\u00a00.098,\n                    <jats:italic>p\u00a0<\/jats:italic>\n                    &lt;\u00a00.001). Mechanistically, infection\u2010driven endothelial dysfunction, microthrombotic activation, and autonomic dysregulation, rather than prolonged inactivity, likely underlie the nocturnal amplification of BP instability. These findings support the need for individualized hypertension management during and after infection, focusing on renin\u2013angiotensin system balance, continuation of ACEI\/ARB therapy, nighttime dosing of long\u2010acting agents, and circadian BP monitoring to mitigate long\u2010term cardiovascular risk.\n                  <\/jats:p>","DOI":"10.1111\/jch.70188","type":"journal-article","created":{"date-parts":[[2025,11,26]],"date-time":"2025-11-26T10:49:05Z","timestamp":1764154145000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Impact of COVID\u201019 Infection on Blood Pressure Variability and Cardiovascular Outcomes in Hypertensive Patients After Complete Liberalization of Epidemic Control in China"],"prefix":"10.1111","volume":"27","author":[{"given":"Quanbin","family":"Su","sequence":"first","affiliation":[{"name":"Department of Cardiology Lanzhou University Second Hospital  Lanzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mingming","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Cardiology Lanzhou University Second Hospital  Lanzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jing","family":"Yu","sequence":"additional","affiliation":[{"name":"Department of Cardiology Lanzhou University Second Hospital  Lanzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,11,26]]},"reference":[{"issue":"12","key":"e_1_2_10_2_1","doi-asserted-by":"crossref","first-page":"1874","DOI":"10.1097\/HJH.0000000000003480","article-title":"2023 ESH Guidelines for the Management of Arterial hypertension The Task Force for the Management of Arterial Hypertension of the European Society of Hypertension: Endorsed by the International Society of Hypertension (ISH) and the European Renal Association (ERA)","volume":"41","author":"Mancia G.","year":"2023","journal-title":"Journal of Hypertension"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140\u20106736(21)01330\u20101"},{"key":"e_1_2_10_4_1","unstructured":"World Health Organization. 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