{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,29]],"date-time":"2025-12-29T05:39:04Z","timestamp":1766986744045,"version":"3.48.0"},"reference-count":17,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2025,12,23]],"date-time":"2025-12-23T00:00:00Z","timestamp":1766448000000},"content-version":"vor","delay-in-days":22,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Clinical Hypertension"],"published-print":{"date-parts":[[2025,12]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>In this study, we investigated the applicability of the ankle\u2013brachial index (ABI) and brachial\u2013ankle index (BAI) in distinguishing aortic stenosis (AS) from lower\u2010extremity arterial stenosis. The difference between the ABI on both sides (\u2206ABI) was defined as the absolute value of the left ABI minus the right ABI. Lower BAI (L\u2010BAI) was defined as the value of the side with the lowest BAI. We obtained four\u2010limb blood pressure measurement data from 6435 patients. AS and bilateral lower\u2010extremity arterial stenosis (BLEAS) were diagnosed. The performance of combined bilateral ABI decline, \u0394ABI, and L\u2010BAI in diagnosing AS was evaluated. The control group showed normal bilateral ABI values, whereas the AS and BLEAS groups exhibited a bilateral ABI decline. The BLEAS group had the highest \u2206ABI compared to the other groups. L\u2010BAI in the BLEAS and AS groups was higher than that in the control group. AS screening using bilateral ABI \u22640.90 combined with \u0394ABI \u22640.10 and L\u2010BAI &gt;1.00 yielded an area under the receiver operating characteristic curve of 0.873 and a Youden index, sensitivity, and specificity of 0.724, 85.2%, and 87.2%, respectively. Validation in 1004 patients revealed a sensitivity, specificity, positive predictive value, negative predictive value, and accuracy of 90.0%, 96.0%, 54.2%, 99.5%, and 95.7%, respectively. In conclusion, combining bilateral ABI \u22640.90, \u2206ABI \u22640.10, and L\u2010BAI &gt;1.00 can effectively screen for AS; this is useful in distinguishing AS from BLEAS, especially in cases of bilateral decline in lower\u2010extremity ABI values.<\/jats:p>","DOI":"10.1111\/jch.70198","type":"journal-article","created":{"date-parts":[[2025,12,23]],"date-time":"2025-12-23T11:58:33Z","timestamp":1766491113000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Effectiveness of Four\u2010Limb Blood Pressure in Distinguishing Between Aortic Stenosis and Bilateral Lower\u2010Extremity Arterial Stenosis"],"prefix":"10.1111","volume":"27","author":[{"ORCID":"https:\/\/orcid.org\/0009-0007-3335-9553","authenticated-orcid":false,"given":"Qian","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Cardiology, State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center for Cardiovascular Diseases Chinese Academy of Medical Sciences and Peking Union Medical College  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6236-9805","authenticated-orcid":false,"given":"Hui","family":"Dong","sequence":"additional","affiliation":[{"name":"Department of Cardiology, State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center for Cardiovascular Diseases Chinese Academy of Medical Sciences and Peking Union Medical College  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hong\u2010Wu","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Cardiology, State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center for Cardiovascular Diseases Chinese Academy of Medical Sciences and Peking Union Medical College  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yu\u2010Bao","family":"Zou","sequence":"additional","affiliation":[{"name":"Department of Cardiology, State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center for Cardiovascular Diseases Chinese Academy of Medical Sciences and Peking Union Medical College  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiong\u2010Jing","family":"Jiang","sequence":"additional","affiliation":[{"name":"Department of Cardiology, State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center for Cardiovascular Diseases Chinese Academy of Medical Sciences and Peking Union Medical College  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,12,23]]},"reference":[{"key":"e_1_2_13_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0741-5214(95)70070-6"},{"key":"e_1_2_13_3_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.101.1.e16"},{"key":"e_1_2_13_4_1","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-159-5-201309030-00007"},{"key":"e_1_2_13_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvs.2009.03.008"},{"key":"e_1_2_13_6_1","doi-asserted-by":"publisher","DOI":"10.1583\/05-1683MR.1"},{"key":"e_1_2_13_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejvs.2014.04.001"},{"key":"e_1_2_13_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00330-007-0749-0"},{"key":"e_1_2_13_9_1","first-page":"e13","article-title":"2017 ACC\/AHA\/AAPA\/ABC\/ACPM\/AGS\/APhA\/ASH\/ASPC\/NMA\/PCNA Guideline for the Prevention, Detection, Evaluation, and Management of High Blood Pressure in Adults: A Report of the American College of Cardiology\/American Heart Association Task Force on Clinical Practice Guidelines","volume":"71","author":"Whelton P. 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