{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,10]],"date-time":"2026-02-10T18:45:40Z","timestamp":1770749140867,"version":"3.50.0"},"reference-count":35,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,1,5]],"date-time":"2026-01-05T00:00:00Z","timestamp":1767571200000},"content-version":"vor","delay-in-days":4,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Clinical Hypertension"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Hypertension is considered a potential risk factor for perioperative ischemic stroke (PIS). However, the association between elevated first systolic blood pressure measured in the operating room (first\u2010OR\u2010SBP) and the incidence of PIS has not been well documented. We conducted a single\u2010center retrospective cohort study including patients who underwent elective non\u2010brain, non\u2010cardiac surgery at Peking University First Hospital between January 1, 2018, and December 31, 2024. Data were extracted from a perioperative database, and patient demographics, intraoperative and perioperative variables\u2014particularly the relationship between first\u2010OR\u2010SBP and PIS\u2014were analyzed. Multivariate logistic regression was performed before and after propensity score matching to adjust for perioperative confounders. The minimum\n                    <jats:italic>p<\/jats:italic>\n                    value approach was used to identify a potential threshold of first\u2010OR\u2010SBP independently associated with PIS risk. We found that, among 105\u00a0059 surgeries, 195 patients (0.19%) experienced PIS. The threshold for first\u2010OR\u2010SBP associated with PIS was identified as 186\u00a0mm Hg. The adjusted odds ratios for PIS were 1.69 (95% CI, 1.12\u20132.55;\n                    <jats:italic>p<\/jats:italic>\n                    \u00a0=\u00a00.013) before matching and 1.62 (95% CI, 1.03\u20132.54;\n                    <jats:italic>p<\/jats:italic>\n                    \u00a0=\u00a00.036) after propensity score matching. We conclude that a first\u2010OR\u2010SBP\u2265186\u00a0mm Hg was significantly associated with an increased risk of perioperative ischemic stroke in patients undergoing elective non\u2010brain, non\u2010cardiac surgery.\n                  <\/jats:p>","DOI":"10.1111\/jch.70201","type":"journal-article","created":{"date-parts":[[2026,1,6]],"date-time":"2026-01-06T05:41:04Z","timestamp":1767678064000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Relationship Between First Systolic Blood Pressure in the Operating Room and Perioperative Ischemic Stroke in Non\u2010Brain Non\u2010Cardiac Surgical Patients"],"prefix":"10.1111","volume":"28","author":[{"given":"Yan","family":"Zhou","sequence":"first","affiliation":[{"name":"Department of Anesthesiology and Critical Care Medicine Peking University First Hospital  \u00a0 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liqing","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery Peking University First Hospital  \u00a0 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lin","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Cardiology Peking University First Hospital  \u00a0 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6456-2307","authenticated-orcid":false,"given":"Hongzhou","family":"Duan","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery Peking University First Hospital  \u00a0 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