{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,27]],"date-time":"2026-01-27T19:39:33Z","timestamp":1769542773344,"version":"3.49.0"},"reference-count":34,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,1,16]],"date-time":"2026-01-16T00:00:00Z","timestamp":1768521600000},"content-version":"vor","delay-in-days":15,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R56HL156806"],"award-info":[{"award-number":["R56HL156806"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01HL155618"],"award-info":[{"award-number":["R01HL155618"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Clinical Hypertension"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Hypertensive disorders of pregnancy (HDP) impact up to 22% of pregnancies. Offspring from HDP, face an increased risk of future cardiovascular disease, with elevated blood pressure reported as early as childhood. Additionally, primary vascular endothelial cells derived from HDP demonstrate dysfunction in vitro. These data suggest that HDP affect fetal development in ways that impair long\u2010term vascular function, supporting the developmental origins of health and disease (DOHaD) theory that health risks begin before birth. However, it remains unclear at what point these physiological changes first emerge and can be detected systemically. To assess whether changes in cardiovascular function can be detected in the immediate post\u2010natal period, we conducted a retrospective analysis of 1655 maternal\u2013infant dyads delivered between the years 2012 and 2025. Using inverse probability weighted regression adjustment, we assessed associations between HDP and newborn heart rate (HR) and blood pressure (BP). Gestational hypertension (GH) and preeclampsia (PE) were associated with higher newborn mean arterial (+2.1\u00a0mmHg,\n                    <jats:italic>p<\/jats:italic>\n                    = 0.02; +2.9\u00a0mmHg,\n                    <jats:italic>p<\/jats:italic>\n                    = 0.04) and diastolic BP (+2.0\u00a0mmHg,\n                    <jats:italic>p<\/jats:italic>\n                    = 0.02; +2.6\u00a0mmHg,\n                    <jats:italic>p<\/jats:italic>\n                    = 0.04) compared to normotension (NT). GH was also associated with increased newborn systolic blood pressure (+2.3\u00a0mmHg,\n                    <jats:italic>p<\/jats:italic>\n                    = 0.04) and increased variability of newborn HR and diastolic BP (+1\u00a0bpm,\n                    <jats:italic>p<\/jats:italic>\n                    = 0.009; +1.4\u00a0mmHg,\n                    <jats:italic>p<\/jats:italic>\n                    = 0.001) compared to normotension. These findings suggest that subtle but measurable newborn cardiovascular alterations associated with GH and PE are present at birth. While the mechanisms remain to be elucidated, these early alterations provide additional temporal insight into the DOHaD in HDP and may reflect underlying vascular dysfunction.\n                  <\/jats:p>","DOI":"10.1111\/jch.70204","type":"journal-article","created":{"date-parts":[[2026,1,16]],"date-time":"2026-01-16T14:03:17Z","timestamp":1768572197000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Elevated Blood Pressure in Newborns From Hypertensive Disorders of Pregnancy During the Immediate Postnatal Period"],"prefix":"10.1111","volume":"28","author":[{"given":"Colman I.","family":"Freel","sequence":"first","affiliation":[{"name":"Department of Cellular and Integrative Physiology University of Nebraska Medical Center  Omaha Nebraska USA"},{"name":"Division of Newborn Medicine Department of Pediatrics University of Nebraska Medical Center  Omaha Nebraska USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Audrey E.","family":"Bavari","sequence":"additional","affiliation":[{"name":"Division of Newborn Medicine Department of Pediatrics University of Nebraska Medical Center  Omaha Nebraska USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Teri J.","family":"Mauch","sequence":"additional","affiliation":[{"name":"Pediatric Nephrology University of Nebraska Medical Center  Omaha Nebraska USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Corrine K.","family":"Hanson","sequence":"additional","affiliation":[{"name":"College of Allied Health Professions University of Nebraska Medical Center  Omaha Nebraska USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paras Kumar","family":"Mishra","sequence":"additional","affiliation":[{"name":"Department of Cellular and Integrative Physiology University of Nebraska Medical Center  Omaha Nebraska USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ann L.","family":"Anderson\u2010Berry","sequence":"additional","affiliation":[{"name":"Division of Newborn Medicine Department of Pediatrics University of Nebraska Medical Center  Omaha Nebraska USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2026,1,16]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598\u2010025\u201085819\u20100"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bpobgyn.2024.102473"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2021.11.819"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12884\u2010021\u201003809\u20102"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.preghy.2012.01.001"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.HYP.0000251522.18094.d4"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2020.00655"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm10143154"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamanetworkopen.2022.42064"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.2174\/1573396316666191224092405"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.118.12569"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.1113\/JP284746"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.1177\/1559827619879694"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.1055\/s\u20100039\u20101695004"},{"key":"e_1_2_12_16_1","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.113.01513"},{"key":"e_1_2_12_17_1","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.116.08414"},{"key":"e_1_2_12_18_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehr300"},{"key":"e_1_2_12_19_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0178340"},{"key":"e_1_2_12_20_1","doi-asserted-by":"publisher","DOI":"10.1038\/hr.2016.180"},{"key":"e_1_2_12_21_1","doi-asserted-by":"publisher","DOI":"10.1097\/AOG.0000000000003891"},{"key":"e_1_2_12_22_1","volume-title":"Preeclampsia 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