{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,15]],"date-time":"2026-07-15T23:53:48Z","timestamp":1784159628221,"version":"3.55.0"},"reference-count":24,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2026,2,18]],"date-time":"2026-02-18T00:00:00Z","timestamp":1771372800000},"content-version":"vor","delay-in-days":17,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Clinical Hypertension"],"published-print":{"date-parts":[[2026,2]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>This study sought to establish age\u2010specific optimal cut\u2010off values for the aldosterone\u2010to\u2010renin ratio (ARR) in screening for primary aldosteronism (PA). The analysis included 281 patients with confirmed PA and 1242 with essential hypertension (EH), categorized into four age groups: \u226439, 40\u201349, 50\u201359, and \u226560 years. A positive correlation was observed between ARR and age in both patient groups. Receiver operating characteristic analysis determined the optimal ARR cut\u2010offs to be 2.3, 2.8, 3.1, and 3.6 for the respective age groups, with all demonstrating high diagnostic accuracy. Further evaluation revealed that for patients under 50\u2010years\u2010old, a unified ARR cut\u2010off of 2.4 provided high sensitivity and specificity, while for patients aged 50 or older, a cut\u2010off of 3.7 was more appropriate. In conclusion, the optimal ARR cut\u2010off for PA screening increases with age, and we recommend using a value of 2.4 for patients under 50 and 3.7 for those aged 50 or older to achieve superior diagnostic performance.<\/jats:p>","DOI":"10.1111\/jch.70218","type":"journal-article","created":{"date-parts":[[2026,2,18]],"date-time":"2026-02-18T16:16:46Z","timestamp":1771431406000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Optimal Cut\u2010Off Values of the Aldosterone\u2010Renin Ratio in Different Age Groups for Primary Aldosteronism Screening"],"prefix":"10.1111","volume":"28","author":[{"given":"Delin","family":"Li","sequence":"first","affiliation":[{"name":"Department of Cardiology First Affiliated Hospital of Dalian Medical University  Dalian Liaoning China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haolin","family":"Song","sequence":"additional","affiliation":[{"name":"Department of Cardiology First Affiliated Hospital of Dalian Medical University  Dalian Liaoning China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Minghui","family":"Gong","sequence":"additional","affiliation":[{"name":"Department of Cardiology First Affiliated Hospital of Dalian Medical University  Dalian Liaoning China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Minghui","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Cardiology First Affiliated Hospital of Dalian Medical University  Dalian Liaoning China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Cardiology First Affiliated Hospital of Dalian Medical University  Dalian Liaoning China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yinong","family":"Jiang","sequence":"additional","affiliation":[{"name":"Department of Cardiology First Affiliated Hospital of Dalian Medical University  Dalian Liaoning China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Song","sequence":"additional","affiliation":[{"name":"Department of Cardiology First Affiliated Hospital of Dalian Medical University  Dalian Liaoning China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,2,18]]},"reference":[{"key":"e_1_2_15_2_1","doi-asserted-by":"publisher","DOI":"10.1155\/2022\/6868941"},{"key":"e_1_2_15_3_1","doi-asserted-by":"publisher","DOI":"10.1093\/clinchem\/hvaa001"},{"key":"e_1_2_15_4_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.123.066389"},{"key":"e_1_2_15_5_1","doi-asserted-by":"publisher","DOI":"10.1210\/clinem\/dgac460"},{"key":"e_1_2_15_6_1","first-page":"5","article-title":"The 2020 Italian Society of Arterial Hypertension (SIIA) Practical Guidelines for the Management of Primary Aldosteronism","volume":"15","author":"Rossi G. 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