{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T01:10:24Z","timestamp":1787015424399,"version":"build-2736575974"},"reference-count":43,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2026,2,24]],"date-time":"2026-02-24T00:00:00Z","timestamp":1771891200000},"content-version":"vor","delay-in-days":23,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Clinical Hypertension"],"published-print":{"date-parts":[[2026,2]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Circadian blood pressure (BP) rhythm disturbances predict cardiovascular risk. Perirenal fat thickness (PRFT) may influence blood pressure regulation, but its role in key circadian phenotypes remains unclear. We examined whether PRFT is associated with disturbances in circadian BP rhythm and short\u2010term blood pressure variability (BPV) in patients with essential hypertension, independently of traditional adiposity indices. In this cross\u2010sectional study of 253 patients, PRFT and other adiposity indices were measured by abdominal CT. Circadian BP rhythm and variability were assessed via 24\u2010hour ambulatory blood pressure monitoring (ABPM). Patients were stratified into PRFT tertiles for analysis. The high PRFT group (Tertile 3) exhibited a significantly higher prevalence of morning hypertension (68.7% vs. 40.0%), nocturnal hypertension (88.0% vs. 63.5%), and a reverse\u2010dipper pattern (20.5% vs. 7.1%) compared to the low PRFT group (Tertile 1) (all\n                    <jats:italic>p<\/jats:italic>\n                    &lt; 0.05). After adjustment for multiple confounders, each 1\u2010mm increase in PRFT remained independently associated with a 10.2%, 15.2%, and 9.9% increased risk of morning hypertension, nocturnal hypertension, and reverse\u2010dipper pattern, respectively. In contrast, traditional adiposity indices (BMI, VFA, TFA) showed no independent associations. PRFT demonstrated the best discriminative performance for nocturnal hypertension (AUC = 0.685) among all fat indices, with the AUC improving to 0.720 upon inclusion of age. No significant association was observed between PRFT and short\u2010term BPV. PRFT is independently associated with disturbed circadian BP rhythm beyond general and visceral adiposity. As a quantifiable CT biomarker, PRFT shows potential clinical utility for assessing high\u2010risk BP rhythm phenotypes.\n                  <\/jats:p>","DOI":"10.1111\/jch.70223","type":"journal-article","created":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T16:09:32Z","timestamp":1772986172000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Perirenal Fat Thickness Is Associated With Disturbed Circadian Blood Pressure Rhythm in Essential Hypertension"],"prefix":"10.1111","volume":"28","author":[{"given":"Shuangqing","family":"Wu","sequence":"first","affiliation":[{"name":"Postgraduate Training Base Alliance of Wenzhou Medical University  Wenzhou Zhejiang China"},{"name":"Department of Cardiology Zhejiang Provincial People's Hospital Affiliated People's Hospital Hangzhou Medical College  Hangzhou Zhejiang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liyu","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Cardiology Zhejiang Provincial People's Hospital Affiliated People's Hospital Hangzhou Medical College  Hangzhou Zhejiang China"},{"name":"The Second School of Clinical Medicine Hangzhou Normal University  Hangzhou Zhejiang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yaqing","family":"Zheng","sequence":"additional","affiliation":[{"name":"Postgraduate Training Base Alliance of Wenzhou Medical University  Wenzhou Zhejiang China"},{"name":"Department of Cardiology Zhejiang Provincial People's Hospital Affiliated People's Hospital Hangzhou Medical College  Hangzhou Zhejiang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yefeng","family":"Shen","sequence":"additional","affiliation":[{"name":"Zhejiang Chinese Medical University  Hangzhou Zhejiang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiameng","family":"Jin","sequence":"additional","affiliation":[{"name":"Zhejiang Chinese Medical University  Hangzhou Zhejiang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Tang","sequence":"additional","affiliation":[{"name":"Department of Cardiology Zhejiang Provincial People's Hospital Affiliated People's Hospital Hangzhou Medical College  Hangzhou Zhejiang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lihong","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Cardiology Zhejiang Provincial People's Hospital Affiliated People's Hospital Hangzhou Medical College  Hangzhou Zhejiang China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,2,24]]},"reference":[{"key":"e_1_2_13_2_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2022.19590"},{"key":"e_1_2_13_3_1","doi-asserted-by":"publisher","DOI":"10.1253\/circj.CJ-20-0972"},{"key":"e_1_2_13_4_1","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.116.005424"},{"key":"e_1_2_13_5_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.120.049730"},{"key":"e_1_2_13_6_1","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2020030236"},{"key":"e_1_2_13_7_1","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.120.16711"},{"key":"e_1_2_13_8_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40885-023-00248-3"},{"key":"e_1_2_13_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/HJH.0000000000003824"},{"key":"e_1_2_13_10_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.ajkd.2022.08.017"},{"key":"e_1_2_13_11_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.ajkd.2022.10.008"},{"key":"e_1_2_13_12_1","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.117.09788"},{"key":"e_1_2_13_13_1","first-page":"95s","article-title":"The Renin\u2013angiotensin\u2013aldosterone System in the Maintenance of Blood Pressure, Aldosterone Secretion and Sodium Balance in Normotensive Subjects","volume":"59","author":"MacGregor G. 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