{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,10]],"date-time":"2026-07-10T14:18:42Z","timestamp":1783693122522,"version":"3.55.0"},"reference-count":43,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2026,6,23]],"date-time":"2026-06-23T00:00:00Z","timestamp":1782172800000},"content-version":"vor","delay-in-days":22,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Clinical Hypertension"],"published-print":{"date-parts":[[2026,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Oral diseases and masticatory dysfunction are more prevalent in hypertensive patients and may hinder blood pressure (BP) control during pharmacological treatment. However, the effect of the oral function on cardiovascular outcomes in patients with poorly controlled hypertension remains unclear. A total of 5\u00a0484 middle\u2010aged and older hypertensive patients receiving antihypertensive medications without prior cardiovascular diseases (CVD) (mean age: 67.5 \u00b1 8.0 years) were followed to investigate incident CVD. Cox proportional hazards models were used to examine associations between the baseline oral status (number of remaining teeth and denture use) and the risk of developing CVD, stratified by BP control status. Poorly controlled BP was defined as systolic BP (SBP) \u2265 130\u00a0mmHg or diastolic BP \u2265 80\u00a0mmHg. Over a mean follow\u2010up period of 9.9 \u00b1 2.7 years, 567 individuals (10.3%) experienced CVD events. In the poorly controlled BP group, tooth loss and non\u2010use of dentures were significantly associated with an increased risk of CVD; the hazard ratios (95% confidence intervals) were 1.79 (1.28\u20132.48) for 10\u201319 teeth, 1.37 (0.97\u20131.94) for 1\u20139 teeth with denture use, 1.56 (1.13\u20132.17) for no teeth with denture use, and 2.17 (1.30\u20133.64) for 0\u20139 teeth with non\u2010use of dentures, compared with \u226520 teeth. This association differed significantly between the poorly controlled and well\u2010controlled BP groups (\n                    <jats:italic>P<\/jats:italic>\n                    for interaction = 0.016). In conclusion, tooth loss and non\u2010use of dentures are associated with a higher risk of CVD among adults with poorly controlled hypertension, suggesting that BP control status under treatment modifies this association.\n                  <\/jats:p>","DOI":"10.1111\/jch.70224","type":"journal-article","created":{"date-parts":[[2026,6,24]],"date-time":"2026-06-24T03:38:47Z","timestamp":1782272327000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Oral Health and Cardiovascular Disease Among Hypertensive Medicated Adults With Uncontrolled Blood Pressure"],"prefix":"10.1111","volume":"28","author":[{"ORCID":"https:\/\/orcid.org\/0009-0007-7817-6128","authenticated-orcid":false,"given":"Yawara","family":"Kikuchi","sequence":"first","affiliation":[{"name":"Department of Internal Medicine Iwate Medical University  Yahaba\u2010cho Iwate 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