{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,27]],"date-time":"2026-03-27T09:48:55Z","timestamp":1774604935069,"version":"3.50.1"},"reference-count":16,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2026,3,18]],"date-time":"2026-03-18T00:00:00Z","timestamp":1773792000000},"content-version":"vor","delay-in-days":17,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Clinical Hypertension"],"published-print":{"date-parts":[[2026,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    This study assessed the efficacy and safety of sacubitril\/valsartan in 27 essential hypertensive patients (mean age 74 years; male 48.1%) after switching from azilsartan, an angiotensin receptor blocker. At baseline and 3 and 6 months after the start of sacubitril\/valsartan treatment, home blood pressure (HBP) and N\u2010terminal pro\u2010brain natriuretic peptide (NT\u2010proBNP) levels were measured. The mean dosage of azilsartan was 27\u00b110\u00a0mg\/day at baseline and that of sacubitril\/valsartan after 6 months of treatment was 170\u00b147\u00a0mg\/day. After 6 months, significant reductions in mean morning HBP (144\u00a0\u00b1\u00a013\/77\u00a0\u00b1\u00a013 to 128\u00a0\u00b1\u00a010\/71\u00a0\u00b1\u00a09\u00a0mmHg) and median (IQR) NT\u2010proBNP level (188.2 [85.3\u2013887.3] to 124.0 [83.6\u2013696.2] pg\/mL) were observed. Twenty\u2010one out of 27 patients accomplished recording of their nighttime HBP, and the morning\u2010nighttime difference in systolic HBP was decreased (8.8\u00a0\u00b1\u00a013.5 to 3.9\u00a0\u00b1\u00a08.5\u00a0mmHg)(all\n                    <jats:italic>p<\/jats:italic>\n                    &lt;\u00a00.05 by repeated\u2010measures ANOVA). In hypertensive patients, sacubitril\/valsartan was generally well tolerated, except for causing hypotension, effectively controlled out\u2010of\u2010office BP, and decreased NT\u2010proBNP.\n                  <\/jats:p>","DOI":"10.1111\/jch.70232","type":"journal-article","created":{"date-parts":[[2026,3,18]],"date-time":"2026-03-18T11:04:41Z","timestamp":1773831881000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Efficacy and Safety of Sacubitril\/Valsartan After Switching From Azilsartan in Essential Hypertensive Patients: Based on Home Blood Pressure Monitoring"],"prefix":"10.1111","volume":"28","author":[{"given":"Yoshio","family":"Iwashima","sequence":"first","affiliation":[{"name":"Department of Geriatric and General Medicine The University of Osaka Graduate School of Medicine  Suita Osaka Japan"},{"name":"Department of Internal Medicine Kansai Medical University Kori Hospital  Neyagawa Osaka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masato","family":"Sugiura","sequence":"additional","affiliation":[{"name":"Department of Clinical Engineering Kansai Medical University Kori Hospital Neyagawa Osaka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takeshi","family":"Horio","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine Ishikiri Seiki Hospital  Higashiosaka Osaka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Koichi","family":"Yamamoto","sequence":"additional","affiliation":[{"name":"Department of Geriatric and General Medicine The University of Osaka Graduate School of Medicine  Suita Osaka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nobuyuki","family":"Takahashi","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Kansai Medical University Kori Hospital  Neyagawa Osaka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2026,3,18]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2020.14545"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41440\u2010022\u201000923\u20102"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140\u20106736(09)61966\u20108"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1093\/ajh\/hpx111"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.113.02002"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/HJH.0000000000001219"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/jch.14635"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc14-S081"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1097\/MBP.0000000000000096"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/hr.2012.56"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12325\u2010024\u201002997\u20105"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1291\/hypres.29.581"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.HYP.0000240332.01877.11"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1097\/HJH.0000000000001379"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.108.115329"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehs262"}],"container-title":["The 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