{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T01:11:03Z","timestamp":1787015463249,"version":"build-2736575974"},"reference-count":55,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Clinical Hypertension"],"published-print":{"date-parts":[[2026,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    The systematic review and meta\u2010analysis aimed to examine the dose\u2010response relationship between isometric handgrip (IHG) training and blood pressure outcomes in normotensive and hypertensive populations. Three databases (EMBASE, MEDLINE\/PubMed, and Cochrane CENTRAL) were searched from inception to June 2025. Thirty\u2010one studies with 905 participants (51% male) met the criteria. Primary outcomes were resting systolic (SBP) and diastolic blood pressure (DBP). Study quality was assessed using the PEDro scale and RoB\u20102. Meta\u2010regression was used to evaluate dose\u2010response effects on SBP and DBP. The included studies demonstrated fair to good methodological quality (5.9 \u00b1 1.0). Moderate evidence indicated that IHG reduced SBP (\u20135.38\u00a0mmHg, 95% CI \u20136.91 to \u20133.85;\n                    <jats:italic>p<\/jats:italic>\n                    \u00a0&lt;\u00a00.001;\n                    <jats:italic>I<\/jats:italic>\n                    <jats:sup>2<\/jats:sup>\n                    \u00a0=\u00a086% and DBP (\u20132.71\u00a0mmHg, 95% CI \u20133.75 to \u20131.66;\n                    <jats:italic>p<\/jats:italic>\n                    \u00a0&lt;\u00a00.001;\n                    <jats:italic>I<\/jats:italic>\n                    <jats:sup>2<\/jats:sup>\n                    \u00a0=\u00a090%), with greater effects observed in hypertensive compared to normotensive groups. For meta\u2010regression, lower training intensity protocols (&lt;30% of maximal voluntary isometric contraction [MVIC]) yield smaller blood pressure\u2010lowering effects in both SBP (\n                    <jats:italic>p<\/jats:italic>\n                    = 0.043) and DBP (\n                    <jats:italic>p<\/jats:italic>\n                    = 0.032). Higher weekly frequency (e.g., &gt;3 to 7 days\/week) was associated with a diminished effect in SBP (\n                    <jats:italic>p<\/jats:italic>\n                    = 0.032). In conclusion, the IHG training significantly lowers SBP and DBP in both normotensive and hypertensive individuals, offering preventive benefits for normotensive individuals at risk for hypertension and therapeutic potential for hypertensive patients. The evidence\u2010informed protocol might appear to be four sets of 2\u2010min unilateral contractions at \u226530 MVIC, performed \u22643 times per week for a minimum of 8 weeks. These findings support IHG as a practical non\u2010pharmacological strategy for blood pressure management.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Registration<\/jats:bold>\n                    : PROSPERO number: CRD420251154235\n                  <\/jats:p>","DOI":"10.1111\/jch.70246","type":"journal-article","created":{"date-parts":[[2026,4,2]],"date-time":"2026-04-02T02:25:19Z","timestamp":1775096719000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["The Optimal Dosage of Isometric Handgrip Exercise for Blood Pressure Reduction: Systematic Review and Meta\u2010Analysis"],"prefix":"10.1111","volume":"28","author":[{"given":"Chia\u2010Wei","family":"Lin","sequence":"first","affiliation":[{"name":"Institute of Allied Health Sciences National Cheng Kung University  Tainan Taiwan"},{"name":"Department of Health and Kinesiology University of Illinois at Urbana\u2010Champaign  Urbana Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ian B.","family":"Jun","sequence":"additional","affiliation":[{"name":"Department of Health and Kinesiology University of Illinois at Urbana\u2010Champaign  Urbana Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vincent","family":"Igbo","sequence":"additional","affiliation":[{"name":"Department of Health and Kinesiology University of Illinois at Urbana\u2010Champaign  Urbana Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amir","family":"Babaniamansour","sequence":"additional","affiliation":[{"name":"Department of Health and Kinesiology University of Illinois at Urbana\u2010Champaign  Urbana Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lingyue","family":"Meng","sequence":"additional","affiliation":[{"name":"Department of Health and Kinesiology University of Illinois at Urbana\u2010Champaign  Urbana Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cheng\u2010Feng","family":"Lin","sequence":"additional","affiliation":[{"name":"Institute of Allied Health Sciences National Cheng Kung University  Tainan Taiwan"},{"name":"Department of Physical Therapy National Cheng Kung University  Tainan Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yih\u2010Kuen","family":"Jan","sequence":"additional","affiliation":[{"name":"Department of Health and Kinesiology University of Illinois at Urbana\u2010Champaign  Urbana Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,4,1]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.0000126208.14181.DD"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.hfc.2019.06.011"},{"key":"e_1_2_9_4_1","unstructured":"World Health Organization Global Report on Hypertension 2025: High Stakes \u2010 Turning Evidence into Action 2025."},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40885-022-00211-8"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41440-021-00720-3"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/MBP.0000000000000655"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40279-024-02036-x"},{"issue":"2","key":"e_1_2_9_9_1","first-page":"1261","article-title":"Isometric Exercise Training: A Review of Hypothesized Mechanisms and Protocol Application in Persons With Hypertension","volume":"14","author":"Rickson J. 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