{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,26]],"date-time":"2026-05-26T16:07:17Z","timestamp":1779811637463,"version":"3.53.1"},"reference-count":33,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2026,5,22]],"date-time":"2026-05-22T00:00:00Z","timestamp":1779408000000},"content-version":"vor","delay-in-days":21,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Clinical Hypertension"],"published-print":{"date-parts":[[2026,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Obstructive sleep apnea (OSA) is associated with increased cardiovascular risk and hypertension. While continuous positive airway pressure (CPAP) therapy reduces blood pressure (BP), its effect shows substantial interindividual variability. Hypoxic burden (HB) has been proposed as a potentially superior predictor of cardiovascular outcomes compared to the apnea\u2013hypopnea index (AHI).<\/jats:p>\n                  <jats:p>In this retrospective study, 141 patients with OSA underwent in\u2010laboratory polysomnography and initiated CPAP therapy. Office BP and clinical parameters were assessed at baseline and follow\u2010up (median 200 days). Receiver operating characteristic (ROC), correlation, multiple linear and logistic regression analyses were performed to compare the predictive value of HB and AHI for BP reduction.<\/jats:p>\n                  <jats:p>CPAP therapy resulted in a modest, non\u2010significant reduction in systolic BP(\u22122.3\u00a0mmHg \u00b117.7,0.1237), while diastolic BP remained unchanged. Higher AHI and HB levels were associated with higher baseline systolic BP and numerically greater BP reductions, particularly in individuals with a higher than the median HB \u226557.5%min\/h or median AHI \u226534.3\/h. However, neither HB nor AHI predicted a systolic BP reduction \u22655\u00a0mmHg (AUC values\u22480.5), and no relevant correlations between AHI, HB and blood pressure response were observed.<\/jats:p>\n                  <jats:p>HB is associated with OSA severity and higher baseline BP. However, it is not superior to AHI in the prediction of a CPAP\u2010associated reduction of BP in patients with OSA.<\/jats:p>","DOI":"10.1111\/jch.70262","type":"journal-article","created":{"date-parts":[[2026,5,22]],"date-time":"2026-05-22T12:07:48Z","timestamp":1779451668000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Apnea\u2013Hypopnea Index Versus Hypoxic Burden as Predictors of Blood Pressure Response to Continuous Positive Airway Pressure Treatment in Patients With Obstructive Sleep Apnoe"],"prefix":"10.1111","volume":"28","author":[{"given":"Sebastian","family":"Bertram","sequence":"first","affiliation":[{"name":"Medical Department 1 University Hospital Marien Hospital Herne, Ruhr\u2010University Bochum  Herne Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diana","family":"Racovitan","sequence":"additional","affiliation":[{"name":"Medical Department 1 University Hospital 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Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simon","family":"Wang","sequence":"additional","affiliation":[{"name":"Medical Department 1 University Hospital Marien Hospital Herne, Ruhr\u2010University Bochum  Herne Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Timm H.","family":"Westhoff","sequence":"additional","affiliation":[{"name":"Medical Department 1 University Hospital Marien Hospital Herne, Ruhr\u2010University Bochum  Herne Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maximilian","family":"Seidel","sequence":"additional","affiliation":[{"name":"Medical Department 1 University Hospital Marien Hospital Herne, Ruhr\u2010University Bochum  Herne 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