{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T21:35:17Z","timestamp":1789767317818,"version":"4.0.1"},"reference-count":30,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T00:00:00Z","timestamp":1777507200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T00:00:00Z","timestamp":1777507200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Clinical Hypertension"],"published-print":{"date-parts":[[2026,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>We aimed to examine the individual and combined impact of prehypertension, prediabetes, and predyslipidemia on all\u2010cause and cardiovascular disease (CVD) mortality in community\u2010dwelling adults. A retrospective cohort study of 11\u00a0986 US adults from the 1999\u20132018 National Health and Nutrition Examination Survey was conducted. Participants were categorized into four mutually exclusive groups based on the cumulative number of these conditions. Multivariate Cox proportional hazards models were applied to calculate the hazard ratios (HRs) and 95% confidence intervals (CIs) for mortality outcomes. The prevalences of no, one, two, and all three preclinical conditions were 37.20%, 38.39%, 19.86%, and 4.55%, respectively. Over a median follow\u2010up of 10 years, 636 (3.83%) deaths occurred, including 170 (26.73%) from CVD. In a dose\u2010response manner, the adjusted HRs (95%CIs) for all\u2010cause mortality among those with one, two, and three conditions were 1.87 (1.38\u20132.52), 2.49 (1.80\u20133.44), and 2.62 (1.76\u20133.90), respectively, compared to those with none. The corresponding HRs (95%CIs) for CVD mortality were 3.09 (1.66\u20135.78), 3.89 (2.06\u20137.36), and 4.20 (2.04\u20138.69), respectively. Thus, an increasing cumulative number of preclinical conditions is associated with graded elevated risk of all\u2010cause and CVD mortality, underscoring the potential for early intervention during the preclinical phase to improve long\u2010term health outcomes.<\/jats:p>","DOI":"10.1111\/jch.70264","type":"journal-article","created":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T10:51:36Z","timestamp":1777546296000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Associations of Cumulative Burden of Prehypertension, Prediabetes and Predyslipidemia With All\u2010Cause and Cardiovascular Disease Mortality: A Retrospective Cohort Study"],"prefix":"10.1111","volume":"28","author":[{"given":"Jiao","family":"Meng","sequence":"first","affiliation":[{"name":"Department of Nephrology, Sir Run Run Shaw Hospital, School of Medicine Zhejiang University  Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gang","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Nephrology Jiangmen Central Hospital  Jiangmen China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1005-059X","authenticated-orcid":false,"given":"Wei","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Sir Run Run Shaw Hospital, School of Medicine Zhejiang University  Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0624-2057","authenticated-orcid":false,"given":"Junnan","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Sir Run Run Shaw Hospital, School of Medicine Zhejiang University  Hangzhou 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