{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,26]],"date-time":"2026-05-26T16:07:13Z","timestamp":1779811633431,"version":"3.53.1"},"reference-count":11,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T00:00:00Z","timestamp":1778630400000},"content-version":"vor","delay-in-days":12,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100006545","name":"National Institute on Minority Health and Health Disparities","doi-asserted-by":"publisher","award":["P50 MD017351\u201001"],"award-info":[{"award-number":["P50 MD017351\u201001"]}],"id":[{"id":"10.13039\/100006545","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000968","name":"American Heart Association","doi-asserted-by":"publisher","award":["AHA 878605"],"award-info":[{"award-number":["AHA 878605"]}],"id":[{"id":"10.13039\/100000968","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Clinical Hypertension"],"published-print":{"date-parts":[[2026,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Results from the ACCOMPLISH (Avoiding Cardiovascular Events through COMbination Therapy in Patients LIving with Systolic Hypertension) trial suggest that combining benazepril with amlodipine, rather than hydrochlorothiazide, provides superior cardiovascular protection potentially in a BP\u2010independent manner. We employed random survival forest, a powerful machine learning approach, to compare the relative importance of risk factors (i.e., variable importance factor (VIF)), focusing on in\u2010trial BP control for predicting the primary composite cardiovascular outcome in the 2 treatment limbs. Among the 6 risk factors with significantly different VIFs between treatments, all were lower under benazepril\/amlodipine combination. The VIF for achieved systolic BP at 6\u2010months was 35% lower in the benazepril\/amlodipine (0.082) versus the benazepril\/hydrochlorothiazide (0.126) limb. The fact that in\u2010trial BP control was less important for preventing cardiovascular events during benazepril\/amlodipine treatment provides novel support for our contention that this combination regimen provides a degree of clinically\u2010relevant cardio\u2010protective actions in a BP\u2010independent manner.<\/jats:p>","DOI":"10.1111\/jch.70278","type":"journal-article","created":{"date-parts":[[2026,5,14]],"date-time":"2026-05-14T06:02:08Z","timestamp":1778738528000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Antihypertensive Combinations Modify Cardiovascular Risk Factor Importance: A Machine Learning Analysis of the ACCOMPLISH Trial"],"prefix":"10.1111","volume":"28","author":[{"given":"Niko","family":"Kaciroti","sequence":"first","affiliation":[{"name":"Departments of Pediatrics and Biostatistics University of Michigan  Ann Arbor Michigan USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Phillip D.","family":"Levy","sequence":"additional","affiliation":[{"name":"Integrative Biosciences Center Wayne State University  Detroit Michigan USA"},{"name":"Department of Emergency Medicine Wayne State University  Detroit Michigan USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenneth A.","family":"Jamerson","sequence":"additional","affiliation":[{"name":"Division of Cardiovascular Medicine, Department of Internal Medicine University of Michigan  Ann Arbor Michigan USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8521-7262","authenticated-orcid":false,"given":"Robert D.","family":"Brook","sequence":"additional","affiliation":[{"name":"Integrative Biosciences Center Wayne State University  Detroit Michigan USA"},{"name":"Division of Cardiovascular Disease, Department of Internal Medicine Wayne State University  Detroit Michigan USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,5,13]]},"reference":[{"key":"e_1_2_14_2_1","doi-asserted-by":"publisher","DOI":"10.1161\/HYP.0000000000000258"},{"key":"e_1_2_14_3_1","doi-asserted-by":"publisher","DOI":"10.1161\/HYP.0000000000000257"},{"key":"e_1_2_14_4_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0806182"},{"key":"e_1_2_14_5_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.120.053151"},{"key":"e_1_2_14_6_1","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.123.22425"},{"key":"e_1_2_14_7_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMc1001410"},{"key":"e_1_2_14_8_1","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.115.002275"},{"key":"e_1_2_14_9_1","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.115.002155"},{"key":"e_1_2_14_10_1","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.124.19468"},{"key":"e_1_2_14_11_1","doi-asserted-by":"publisher","DOI":"10.1093\/ajh\/hpaf051"},{"key":"e_1_2_14_12_1","unstructured":"R Core Team R: A Language and Environment for Statistical Computing(R Foundation for Statistical Computing 2026).https:\/\/www.R\u2010project.org\/."}],"container-title":["The Journal of Clinical Hypertension"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jch.70278","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/jch.70278","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jch.70278","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,26]],"date-time":"2026-05-26T16:00:01Z","timestamp":1779811201000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jch.70278"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5]]},"references-count":11,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2026,5]]}},"alternative-id":["10.1111\/jch.70278"],"URL":"https:\/\/doi.org\/10.1111\/jch.70278","archive":["Portico"],"relation":{},"ISSN":["1524-6175","1751-7176"],"issn-type":[{"value":"1524-6175","type":"print"},{"value":"1751-7176","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,5]]},"assertion":[{"value":"2026-01-10","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-04-30","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-05-13","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70278"}}