{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,26]],"date-time":"2026-05-26T16:07:17Z","timestamp":1779811637674,"version":"3.53.1"},"reference-count":53,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T00:00:00Z","timestamp":1778630400000},"content-version":"vor","delay-in-days":12,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Clinical Hypertension"],"published-print":{"date-parts":[[2026,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Low\u2010dose single\u2010pill combinations (SPCs) are gaining recognition as an efficient therapeutic strategy for mild hypertension. However, evidence from randomized controlled trials regarding the efficacy and safety of half\u2010dose telmisartan\/amlodipine SPCs remains limited. In this randomized, double\u2010blind, active\u2010controlled phase III trial, patients with essential hypertension [mean sitting systolic blood pressure (MSSBP) \u2265 140 and &lt; 180\u00a0mmHg] were allocated to four treatment arms to receive either telmisartan\/amlodipine 20\/2.5\u00a0mg SPC (TEL\/AML 20\/2.5), or monotherapy with telmisartan 20\u00a0mg (TEL 20), amlodipine 2.5\u00a0mg (AML 2.5), or telmisartan 40\u00a0mg (TEL 40) once daily for 8\u00a0weeks. The primary endpoint was the change in MSSBP from baseline to week 8. A gatekeeping approach was used to test the superiority of TEL\/AML 20\/2.5 over TEL 20 and AML 2.5, followed by non\u2010inferiority versus TEL 40. At week 8, TEL\/AML 20\/2.5 showed significantly greater MSSBP reductions compared with TEL 20 [least squares mean (LSM) differences: \u22125.79\u00a0mmHg;\n                    <jats:italic>p<\/jats:italic>\n                    = 0.0003] and AML 2.5 (\u22128.57\u00a0mmHg;\n                    <jats:italic>p<\/jats:italic>\n                    &lt; 0.0001). Non\u2010inferiority to TEL 40 was established, with an LSM difference of \u22123.88\u00a0mmHg (95% Confidence Interval: \u22126.67 to \u22121.09), which met the pre\u2010specified 3\u00a0mmHg margin. The overall incidence of adverse events was 8.05%, with no statistically significant differences between groups. Overall, TEL\/AML 20\/2.5 SPC provided superior BP\u2010lowering efficacy compared with TEL 20 and AML 2.5 monotherapies and was non\u2010inferior to TEL 40. With a comparable safety profile across treatment groups, these findings suggest that TEL\/AML 20\/2.5 is a practical and effective option for hypertension management.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Trial Registration<\/jats:bold>\n                    : ClinicalTrials.gov, NCT06052748\n                  <\/jats:p>","DOI":"10.1111\/jch.70279","type":"journal-article","created":{"date-parts":[[2026,5,14]],"date-time":"2026-05-14T06:05:45Z","timestamp":1778738745000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Low\u2010Dose Telmisartan\/Amlodipine in Essential Hypertension: A Phase III Trial"],"prefix":"10.1111","volume":"28","author":[{"given":"Hyo\u2010Suk","family":"Ahn","sequence":"first","affiliation":[{"name":"Division of Cardiology, Department of Internal Medicine College of Medicine Uijeongbu St. Mary's Hospital, The Catholic University of Korea  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