{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T17:00:04Z","timestamp":1782925204660,"version":"3.54.5"},"reference-count":27,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T00:00:00Z","timestamp":1778630400000},"content-version":"vor","delay-in-days":12,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2022YFC3602501\uff1a2021YFC2500601"],"award-info":[{"award-number":["2022YFC3602501\uff1a2021YFC2500601"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82470465"],"award-info":[{"award-number":["82470465"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Clinical Hypertension"],"published-print":{"date-parts":[[2026,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    High\u2010sensitivity cardiac troponin T (hs\u2010cTnT) and\/or N\u2010terminal pro\u2010B\u2010type natriuretic peptide (NT\u2010proBNP) levels are associated with left ventricular structure and function in general populations, however, evidence regarding their relationship with multidimensional echocardiographic features in patients with hypertension remains limited. Hypertensive adults (aged \u226518 years) from a multicenter prospective cohort who underwent echocardiography from 2017 to 2020 were included in this study. Associations of serum hs\u2010cTnT and NT\u2010proBNP, alone and combined, with echocardiographic features were evaluated in multivariable\u2010adjusted models. Among a total of 1803 hypertensive participants (mean age, 51.0\u00a0\u00b1\u00a011.9 years; 29.7% women), the median levels of hs\u2010cTnT and NT\u2010proBNP were 5.13\u00a0ng\/L (IQR 3.68, 7.30) and 32.80\u00a0ng\/L (IQR 17.85, 59.25), respectively. Participants in the highest hs\u2010cTnT tertile showed greater left ventricular and atrial remodeling and higher flow velocity than those in the lowest tertile, including mean increases of 0.59\u00a0mm in left ventricular end\u2010diastolic diameter (95% CI 0.02\u20131.16), 2.78\u00a0g\/m\n                    <jats:sup>2<\/jats:sup>\n                    in left ventricular mass index (95% CI 0.32\u20135.24), 3.61\u00a0cm\/s in aortic valve velocity (95% CI 0.54\u20136.67), and 0.61\u00a0mm in left atrial diameter (95% CI 0.09\u20131.13). Elevated NT\u2010proBNP levels were also associated with these structural changes, along with impaired diastolic function and arterial enlargement. Participants with the highest tertiles for both biomarkers had more pronounced cardiac structural and functional abnormalities, including increased interventricular septum thickness and worse diastolic function. Elevations in hs\u2010cTnT and\/or NT\u2010proBNP are associated with subclinical changes in cardiac structure and function in hypertensive patients.\n                  <\/jats:p>","DOI":"10.1111\/jch.70280","type":"journal-article","created":{"date-parts":[[2026,5,14]],"date-time":"2026-05-14T05:57:37Z","timestamp":1778738257000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Associations of High\u2010Sensitivity Cardiac Troponin and N\u2010Terminal Pro\u2010B\u2010Type Natriuretic Peptide With Echocardiographic Features in Patients With Hypertension"],"prefix":"10.1111","volume":"28","author":[{"given":"Mingdan","family":"Wang","sequence":"first","affiliation":[{"name":"Center For Clinical and Epidemiologic Research Beijing Anzhen Hospital, Capital Medical University Beijing Institute of Heart, Lung and Blood Vessel Diseases National Clinical Research Center For Cardiovascular Diseases Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xihan","family":"Li","sequence":"additional","affiliation":[{"name":"Center For Clinical and Epidemiologic Research Beijing Anzhen Hospital, Capital Medical University Beijing Institute of Heart, Lung and Blood Vessel Diseases National Clinical Research Center For Cardiovascular Diseases Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lingyue","family":"Qiu","sequence":"additional","affiliation":[{"name":"Center For Clinical and Epidemiologic Research Beijing Anzhen Hospital, Capital Medical University Beijing Institute of Heart, Lung and Blood Vessel Diseases National Clinical Research Center For Cardiovascular Diseases Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhen","family":"Wang","sequence":"additional","affiliation":[{"name":"Center For Clinical and Epidemiologic Research Beijing Anzhen Hospital, Capital Medical University Beijing Institute of Heart, Lung and Blood Vessel Diseases National Clinical Research Center For Cardiovascular Diseases Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiamiao","family":"Li","sequence":"additional","affiliation":[{"name":"Center For Clinical and Epidemiologic Research Beijing Anzhen Hospital, Capital Medical University Beijing Institute of Heart, Lung and Blood Vessel Diseases National Clinical Research Center For Cardiovascular Diseases Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiayi","family":"Sun","sequence":"additional","affiliation":[{"name":"Center For Clinical and Epidemiologic Research Beijing Anzhen Hospital, Capital Medical University Beijing Institute of Heart, Lung and Blood Vessel Diseases National Clinical Research Center For Cardiovascular Diseases Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lizhen","family":"Han","sequence":"additional","affiliation":[{"name":"Center For Clinical and Epidemiologic Research Beijing Anzhen Hospital, Capital Medical University Beijing Institute of Heart, Lung and Blood Vessel Diseases National Clinical Research Center For Cardiovascular Diseases Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Na","family":"Yang","sequence":"additional","affiliation":[{"name":"Center For Clinical and Epidemiologic Research Beijing Anzhen Hospital, Capital Medical University Beijing Institute of Heart, Lung and Blood Vessel Diseases National Clinical Research Center For Cardiovascular Diseases Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yongchen","family":"Hao","sequence":"additional","affiliation":[{"name":"Center For Clinical and Epidemiologic Research Beijing Anzhen Hospital, Capital Medical University Beijing Institute of Heart, Lung and Blood Vessel Diseases National Clinical Research Center For Cardiovascular Diseases Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rong","family":"Hu","sequence":"additional","affiliation":[{"name":"Department of Cardiology Beijing Anzhen Hospital Capital Medical University National Clinical Research Center for Cardiovascular Diseases Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6709-7041","authenticated-orcid":false,"given":"Yue","family":"Qi","sequence":"additional","affiliation":[{"name":"Center For Clinical and Epidemiologic Research Beijing Anzhen Hospital, Capital Medical University Beijing Institute of Heart, Lung and Blood Vessel Diseases National Clinical Research Center For Cardiovascular Diseases Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3311-0818","authenticated-orcid":false,"given":"Jing","family":"Liu","sequence":"additional","affiliation":[{"name":"Center For Clinical and Epidemiologic Research Beijing Anzhen Hospital, Capital Medical University Beijing Institute of Heart, Lung and Blood Vessel Diseases National Clinical Research Center For Cardiovascular Diseases Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,5,13]]},"reference":[{"key":"e_1_2_13_2_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2023.5942"},{"key":"e_1_2_13_3_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehac393"},{"issue":"1","key":"e_1_2_13_4_1","first-page":"54","article-title":"[Heart Effect of Arterial Hypertension. 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