{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T04:05:03Z","timestamp":1785297903841,"version":"3.55.0"},"reference-count":19,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T00:00:00Z","timestamp":1783036800000},"content-version":"vor","delay-in-days":2,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100017686","name":"Fujian Provincial Health Technology Project","doi-asserted-by":"publisher","award":["2023GGA059"],"award-info":[{"award-number":["2023GGA059"]}],"id":[{"id":"10.13039\/501100017686","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100017686","name":"Fujian Provincial Health Technology Project","doi-asserted-by":"publisher","award":["2024ZD01005"],"award-info":[{"award-number":["2024ZD01005"]}],"id":[{"id":"10.13039\/501100017686","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Clinical Hypertension"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>This retrospective study of 4143 women at Fujian Maternal and Child Health Hospital (2012\u20132022) investigated how maternal risk levels influence clinical characteristics and perinatal outcomes in singleton pregnancies complicated by preeclampsia. Utilizing class\u2010imbalance\u2010adjusted and random forest algorithms, participants were stratified into high\u2010risk (17.38%), moderate\u2010risk (34.08%), and low\u2010risk (48.54%) groups. The analysis revealed that women in the high\u2010risk category were diagnosed at a significantly earlier gestational age and faced higher rates of severe, early\u2010onset, and preterm preeclampsia compared to the other groups. Although high\u2010risk pregnancies were associated with increased incidences of renal impairment, hypoproteinemia, and aminotransferase abnormalities, no significant differences were observed in rates of thrombocytopenia, placental abruption, postpartum hemorrhage, or stillbirth. Regarding delivery and neonatal outcomes, the high\u2010risk group demonstrated markedly higher rates of Cesarean sections, fetal distress, and neonatal intensive care unit (NICU) admissions. Key drivers of these adverse outcomes included chronic hypertension, chronic kidney disease, prior fetal growth restriction (FGR), and maternal age over 40\u00a0years. Ultimately, while high\u2010risk status is a strong predictor of early\u2010onset disease and specific maternal\u2010neonatal complications, it does not uniformly predict all adverse fetal outcomes, suggesting that clinical management should focus heavily on the specific impacts of hypertension, renal health, and advanced maternal age.<\/jats:p>","DOI":"10.1111\/jch.70290","type":"journal-article","created":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T13:01:06Z","timestamp":1783083666000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Impact of Maternal Risk Stratification on Clinical Characteristics and Perinatal Outcomes in Singleton Pregnancies With Preeclampsia"],"prefix":"10.1111","volume":"28","author":[{"given":"Qian","family":"Yu","sequence":"first","affiliation":[{"name":"College of Clinical Medicine for Obstetrics &amp; Gynecology and Pediatrics, Fujian Medical University, Department of Obstetrics and Gynecology Fujian Maternity and Child Health Hospital"},{"name":"Fujian Maternity and Child Health Hospital  Fuzhou Fujian PR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zewei","family":"Liang","sequence":"additional","affiliation":[{"name":"College of Clinical Medicine for Obstetrics &amp; Gynecology and Pediatrics, Fujian Medical University, Department of Obstetrics and Gynecology Fujian Maternity and Child Health Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4289-3444","authenticated-orcid":false,"given":"Jiaying","family":"Zheng","sequence":"additional","affiliation":[{"name":"College of Clinical Medicine for Obstetrics &amp; Gynecology and Pediatrics, Fujian Medical University, Department of Obstetrics and Gynecology Fujian Maternity and Child Health Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chengcheng","family":"Jin","sequence":"additional","affiliation":[{"name":"College of Clinical Medicine for Obstetrics &amp; Gynecology and Pediatrics, Fujian Medical University, Department of Obstetrics and Gynecology Fujian Maternity and Child Health Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xingyi","family":"Qi","sequence":"additional","affiliation":[{"name":"College of Clinical Medicine for Obstetrics &amp; Gynecology and Pediatrics, Fujian Medical University, Department of Obstetrics and Gynecology Fujian Maternity and Child Health Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianying","family":"Yan","sequence":"additional","affiliation":[{"name":"College of Clinical Medicine for Obstetrics &amp; Gynecology and Pediatrics, Fujian Medical University, Department of Obstetrics and Gynecology Fujian Maternity and Child Health Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xia","family":"Xu","sequence":"additional","affiliation":[{"name":"College of Clinical Medicine for Obstetrics &amp; Gynecology and Pediatrics, Fujian Medical University, Department of Obstetrics and Gynecology Fujian Maternity and Child Health Hospital"},{"name":"Fujian Maternity and Child Health Hospital  Fuzhou Fujian PR China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,7,3]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamanetworkopen.2021.3808"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/obr.13411"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamanetworkopen.2023.0034"},{"key":"e_1_2_12_5_1","unstructured":"\u201cGestational Hypertension and Preeclampsia: ACOG Practice Bulletin Number 222 \u201d ."},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.17455"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.l5119"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1097\/OGX.0000000000000942"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jogc.2022.03.002"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2020.07.020"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jogc.2019.03.026"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.diabres.2023.110793"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.3389\/fcimb.2022.940937"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11906\u2010023\u201001250\u20108"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.i1753"},{"key":"e_1_2_12_16_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41440\u2010024\u201001623\u20109"},{"key":"e_1_2_12_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00404\u2010024\u201007751\u20104"},{"key":"e_1_2_12_18_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12884\u2010024\u201006476\u20101"},{"key":"e_1_2_12_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002\u20109378(00)70225\u20100"},{"key":"e_1_2_12_20_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13048\u2010023\u201001331\u2010x"}],"container-title":["The Journal of Clinical Hypertension"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jch.70290","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/jch.70290","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jch.70290","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T03:32:42Z","timestamp":1785295962000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jch.70290"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7]]},"references-count":19,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2026,7]]}},"alternative-id":["10.1111\/jch.70290"],"URL":"https:\/\/doi.org\/10.1111\/jch.70290","archive":["Portico"],"relation":{},"ISSN":["1524-6175","1751-7176"],"issn-type":[{"value":"1524-6175","type":"print"},{"value":"1751-7176","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,7]]},"assertion":[{"value":"2026-03-16","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-05-04","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-07-03","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70290"}}