{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T16:28:02Z","timestamp":1789057682071,"version":"build-2803163510"},"reference-count":33,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T00:00:00Z","timestamp":1780358400000},"content-version":"vor","delay-in-days":1,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81873513"],"award-info":[{"award-number":["81873513"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81600574"],"award-info":[{"award-number":["81600574"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["30871042"],"award-info":[{"award-number":["30871042"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Clinical Hypertension"],"published-print":{"date-parts":[[2026,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Hypertension is a major modifiable risk factor for chronic kidney disease (CKD), accelerating renal injury by promoting arterial stiffness. Estimated pulse wave velocity (ePWV), an indicator of arterial stiffness, is associated with CKD progression, but its relationship with urinary albumin\u2010to\u2010creatinine ratio (UACR) in non\u2010diabetic hypertensive patients remains unclear. This retrospective study included 509 non\u2010diabetic adults with essential hypertension. Participants were classified as having early renal impairment (UACR \u226530\u00a0mg\/g,\n                    <jats:italic>n<\/jats:italic>\n                    = 167) or not (UACR &lt;30\u00a0mg\/g,\n                    <jats:italic>n<\/jats:italic>\n                    = 342). ePWV was calculated from age and mean blood pressure (MBP). The impairment group showed significantly higher ePWV (\n                    <jats:italic>P<\/jats:italic>\n                    \u00a0&lt;\u00a00.001). Restricted cubic splines revealed a positive linear correlation between ePWV and UACR (\n                    <jats:italic>P<\/jats:italic>\n                    for nonlinear = 0.938). Multivariable logistic regression identified that ePWV was an independent risk factor for early renal impairment. Each 1\u00a0m\/s increase in ePWV was associated with a 43.9% elevated risk of early renal impairment (OR = 1.439, 95% CI: 1.176\u20131.761), with the highest ePWV quartile (&gt;9.70 m\/s) showing an OR of 4.894 (95% CI: 2.019\u201311.86). ROC analysis showed\u00a0that ePWV had the highest AUC at 0.710, higher than age (0.585) and MBP (0.693),\u00a0and it provided greater incremental value for identifying early renal impairment than age and MBP when incorporated into the base model. Subgroup analyses by sex, age, BMI, and eGFR consistently supported these associations. In conclusion, ePWV is an independent risk marker for early renal impairment in non\u2010diabetic hypertensive patients, supporting its potential use in early risk stratification.\n                  <\/jats:p>","DOI":"10.1111\/jch.70295","type":"journal-article","created":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T09:15:24Z","timestamp":1780391724000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Estimated Pulse Wave Velocity Is Associated with Early Renal Impairment in Non\u2010Diabetic Hypertensive Patients"],"prefix":"10.1111","volume":"28","author":[{"given":"Kamila","family":"Kamili","sequence":"first","affiliation":[{"name":"Department of Cardiovascular Medicine First Affiliated Hospital of Xi'an Jiaotong University  Xi'an China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Zhuo","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine First Affiliated Hospital of Xi'an Jiaotong University  Xi'an China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Danni","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine First Affiliated Hospital of Xi'an Jiaotong University  Xi'an China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suining","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine First Affiliated Hospital of Xi'an Jiaotong University  Xi'an China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiyang","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine First Affiliated Hospital of Xi'an Jiaotong University  Xi'an China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pengjie","family":"Gao","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine First Affiliated Hospital of Xi'an Jiaotong University  Xi'an China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yiran","family":"Yan","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine First Affiliated Hospital of Xi'an Jiaotong University  Xi'an China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haijian","family":"Xing","sequence":"additional","affiliation":[{"name":"Department of Outpatient Internal Medicine Affiliated Children's Hospital of Xi'an Jiaotong University  Xi'an China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gang","family":"Tian","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine First Affiliated Hospital of Xi'an Jiaotong University  Xi'an China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,6,2]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.kint.2023.10.018"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.kisu.2024.12.001"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmed.2021.765924"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.HYP.0000236599.91051.1e"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1093\/ajh\/hpz193"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gft309"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.hjh.0000572712.37152.3c"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2019.07.012"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1097\/HJH.0000000000000935"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmed.2025.1560272"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11255-025-04660-6"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1080\/0886022X.2024.2387932"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1253\/circj.CJ\u201023\u20100674"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.7326\/0003\u20104819\u2010150\u20109\u2010200905050\u201000006"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/jch.14971"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1161\/HYP.0000000000000087"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.ajkd.2024.01.001"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.kint.2024.12.017"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1038\/jhh.2013.55"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrneph.2015.172"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2014050450"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.121.318061"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.2196\/45324"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehl254"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehq165"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.2215\/CJN.07900812"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1097\/HJH.0000000000003137"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.2215\/CJN.03000315"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0735\u20101097(25)01029\u20100"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.3389\/fcvm.2023.1157163"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12872\u2010024\u201004453\u20102"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmed.2025.1636846"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.1124\/pr.107.08002"}],"container-title":["The Journal of Clinical Hypertension"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jch.70295","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/jch.70295","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jch.70295","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,10]],"date-time":"2026-07-10T13:47:44Z","timestamp":1783691264000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jch.70295"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6]]},"references-count":33,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2026,6]]}},"alternative-id":["10.1111\/jch.70295"],"URL":"https:\/\/doi.org\/10.1111\/jch.70295","archive":["Portico"],"relation":{},"ISSN":["1524-6175","1751-7176"],"issn-type":[{"value":"1524-6175","type":"print"},{"value":"1751-7176","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,6]]},"assertion":[{"value":"2026-03-09","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-05-13","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-06-02","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70295"}}