{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,20]],"date-time":"2026-07-20T20:57:53Z","timestamp":1784581073073,"version":"3.55.0"},"reference-count":40,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2026,5,31]],"date-time":"2026-05-31T00:00:00Z","timestamp":1780185600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,5,31]],"date-time":"2026-05-31T00:00:00Z","timestamp":1780185600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Clinical Hypertension"],"published-print":{"date-parts":[[2026,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Frailty has been increasingly recognized as an important predictor of cardiovascular disease (CVD) risk; however, the modifying role of systolic blood pressure (SBP) in this association remains unclear. Using data from the China Health and Retirement Longitudinal Study, we included 7210 community\u2010dwelling adults aged \u226545 years and assessed frailty status using a constructed frailty index. Participants were stratified according to SBP levels, and incident CVD events were ascertained during follow\u2010up. Cox proportional hazards models were applied to evaluate the association between frailty and CVD risk, with SBP examined as an effect modifier. Over 53\u00a0531 person\u2010years of follow\u2010up, 1663 CVD events occurred. Frailty was consistently associated with a higher risk of CVD across all SBP strata. Each standard deviation increase in the frailty index was associated with a 28% higher CVD risk among participants with SBP &lt;120\u00a0mmHg, a 54% higher risk among those with SBP 120\u2013129\u00a0mmHg, and a 25% higher risk among those with SBP \u2265130\u00a0mmHg. Joint analysis demonstrated that frail individuals with SBP 120\u2013129\u00a0mmHg had the highest CVD risk (hazard ratio 3.40; 95% confidence interval 2.54\u20134.57). Sensitivity analyses confirmed a robust interaction between SBP and frailty in relation to CVD risk. These findings indicate that frailty substantially increases CVD risk across all SBP categories, with the greatest risk observed in frail individuals with high\u2010normal SBP, suggesting that individualized blood pressure targets incorporating frailty status may optimize cardiovascular prevention rather than uniformly pursuing lower SBP levels.<\/jats:p>","DOI":"10.1111\/jch.70302","type":"journal-article","created":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T06:10:00Z","timestamp":1780294200000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["The Effect Modification of Systolic Blood Pressure on the Association of Frailty and Cardiovascular Disease in Community\u2010Dwelling Adults"],"prefix":"10.1111","volume":"28","author":[{"given":"Rui","family":"Song","sequence":"first","affiliation":[{"name":"Department of Neurology West China School of Medicine Sichuan University Sichuan University Affiliated Chengdu Second People's Hospital  Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuemin","family":"Zhong","sequence":"additional","affiliation":[{"name":"Department of Neurology West China School of Medicine Sichuan University Sichuan University Affiliated Chengdu Second People's Hospital  Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junying","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Neurology West China School of Medicine Sichuan University Sichuan University Affiliated Chengdu Second People's Hospital  Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yirong","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Neurology West China School of Medicine Sichuan University Sichuan University Affiliated Chengdu Second People's Hospital  Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luxi","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Neurology West China School of Medicine Sichuan University Sichuan University Affiliated Chengdu Second People's Hospital  Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Neurology West China School of Medicine Sichuan University Sichuan University Affiliated Chengdu Second People's Hospital  Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,5,31]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2023.11.007"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehab484"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140\u20106736(12)62167\u20109"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1532\u20105415.2006.00745.x"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehab468"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehab850"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1093\/ageing\/afac311"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140\u20106736(21)00590\u20100"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/ajh.2010.185"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen\u20102021\u2010056395"},{"key":"e_1_2_12_12_1","first-page":"S13","article-title":"Alterations in Neural Cardiovascular Control Mechanisms With Ageing","volume":"12","author":"Giannattasio C.","year":"1994","journal-title":"Journal of Hypertension Supplement"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.1093\/geroni\/igx004.088"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.1080\/00325481.2022.2039007"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.121.17530"},{"key":"e_1_2_12_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12603\u2010022\u20101850\u20104"},{"key":"e_1_2_12_17_1","doi-asserted-by":"publisher","DOI":"10.1093\/ije\/dys203"},{"key":"e_1_2_12_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcsm.13169"},{"key":"e_1_2_12_19_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehad885"},{"key":"e_1_2_12_20_1","doi-asserted-by":"publisher","DOI":"10.1093\/ageing\/afad221"},{"key":"e_1_2_12_21_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471\u20102318\u20108\u201024"},{"key":"e_1_2_12_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2468\u20102667(20)30113\u20104"},{"key":"e_1_2_12_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140\u20106736(19)31786\u20106"},{"key":"e_1_2_12_24_1","doi-asserted-by":"publisher","DOI":"10.7326\/0003\u20104819\u2010145\u20104\u2010200608150\u201000004"},{"key":"e_1_2_12_25_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12933\u2010024\u201002227\u2010w"},{"key":"e_1_2_12_26_1","doi-asserted-by":"publisher","DOI":"10.1161\/HYP.0000000000000065"},{"key":"e_1_2_12_27_1","doi-asserted-by":"publisher","DOI":"10.1097\/HJH.0000000000003480"},{"key":"e_1_2_12_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.arr.2022.101789"},{"key":"e_1_2_12_29_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12986\u2010017\u20100206\u20102"},{"key":"e_1_2_12_30_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcsm.13001"},{"key":"e_1_2_12_31_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.123.064003"},{"key":"e_1_2_12_32_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12916\u2010015\u20100328\u20101"},{"key":"e_1_2_12_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eclinm.2022.101304"},{"key":"e_1_2_12_34_1","doi-asserted-by":"publisher","DOI":"10.3390\/jpm12030418"},{"key":"e_1_2_12_35_1","doi-asserted-by":"publisher","DOI":"10.1093\/gerona\/gls190"},{"key":"e_1_2_12_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mcna.2022.04.006"},{"key":"e_1_2_12_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.exger.2021.111557"},{"key":"e_1_2_12_38_1","doi-asserted-by":"publisher","DOI":"10.7717\/peerj.17760"},{"key":"e_1_2_12_39_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamainternmed.2017.7023"},{"key":"e_1_2_12_40_1","doi-asserted-by":"publisher","DOI":"10.1001\/archsurg.138.10.1055"},{"key":"e_1_2_12_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.exger.2021.111480"}],"container-title":["The Journal of Clinical Hypertension"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jch.70302","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/jch.70302","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jch.70302","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,10]],"date-time":"2026-07-10T13:47:32Z","timestamp":1783691252000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jch.70302"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5,31]]},"references-count":40,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2026,6]]}},"alternative-id":["10.1111\/jch.70302"],"URL":"https:\/\/doi.org\/10.1111\/jch.70302","archive":["Portico"],"relation":{},"ISSN":["1524-6175","1751-7176"],"issn-type":[{"value":"1524-6175","type":"print"},{"value":"1751-7176","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,5,31]]},"assertion":[{"value":"2026-01-08","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-05-20","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-05-31","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70302"}}