{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T04:05:12Z","timestamp":1785297912573,"version":"3.55.0"},"reference-count":29,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2026,7,25]],"date-time":"2026-07-25T00:00:00Z","timestamp":1784937600000},"content-version":"vor","delay-in-days":24,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82370426"],"award-info":[{"award-number":["82370426"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82270469"],"award-info":[{"award-number":["82270469"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82070435"],"award-info":[{"award-number":["82070435"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82070432"],"award-info":[{"award-number":["82070432"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100017950","name":"Shanghai Municipal Health Commission","doi-asserted-by":"publisher","award":["202340035"],"award-info":[{"award-number":["202340035"]}],"id":[{"id":"10.13039\/100017950","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100017950","name":"Shanghai Municipal Health Commission","doi-asserted-by":"publisher","award":["2024ZZ1028"],"award-info":[{"award-number":["2024ZZ1028"]}],"id":[{"id":"10.13039\/100017950","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100017950","name":"Shanghai Municipal Health Commission","doi-asserted-by":"publisher","award":["2022LJ022"],"award-info":[{"award-number":["2022LJ022"]}],"id":[{"id":"10.13039\/100017950","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Clinical Hypertension"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    We performed a post hoc exploratory secondary analysis to investigate whether baseline circadian blood pressure (BP) pattern was associated with changes in serum uric acid (SUA) during 8\u2010week antihypertensive therapy. Of the 494 hypertensive patients who received amlodipine (5\u201310\u00a0mg) or nifedipine GITS (30\u201360\u00a0mg) for 8 weeks, 369 patients with available laboratory data and valid follow\u2010up ambulatory BP monitoring data were included in the present analysis, including 221 dippers (nocturnal systolic BP decline \u2265 10%) and 148 non\u2010dippers (nocturnal systolic BP decline &lt; 10%). Analysis of covariance was used to estimate least square mean changes in SUA according to baseline dipping pattern. After 8\u2010week antihypertensive treatment, SUA decreased significantly in dippers (\u221212.4 \u00b1 3.4\u00a0\u00b5mol\/L,\n                    <jats:italic>p<\/jats:italic>\n                    = 0.0004) but not in non\u2010dippers (\u22123.3 \u00b1 4.2\u00a0\u00b5mol\/L,\n                    <jats:italic>p<\/jats:italic>\n                    = 0.44). In the repeated\u2010measures analysis, SUA levels decreased significantly over time (\n                    <jats:italic>p<\/jats:italic>\n                    = 0.002), whereas no significant time\u2010by\u2010dipping interaction was observed (\n                    <jats:italic>p<\/jats:italic>\n                    = 0.23). Baseline BP dipping pattern may be modestly associated with short\u2010term SUA changes during antihypertensive therapy. However, the absence of a significant time\u2010by\u2010dipping interaction suggests that these findings should be interpreted cautiously and require further confirmation.\n                  <\/jats:p>","DOI":"10.1111\/jch.70324","type":"journal-article","created":{"date-parts":[[2026,7,25]],"date-time":"2026-07-25T14:29:21Z","timestamp":1784989761000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Serum Uric Acid Changes in Relation to Nighttime Blood Pressure Dipping Status in Patients on Antihypertensive Therapy"],"prefix":"10.1111","volume":"28","author":[{"given":"Di","family":"Zhang","sequence":"first","affiliation":[{"name":"Shanghai Geriatric Medical Center, Zhongshan Hospital Fudan University Minhang Meilong  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qi\u2010Fang","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine Shanghai Institute of Hypertension Shanghai Key Laboratory of Hypertension National Research Centre For Translational Medicine State Key Laboratory of Medical Genomics, Ruijin Hospital Shanghai Jiatong University School of Medicine  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine Shanghai Institute of Hypertension Shanghai Key Laboratory of Hypertension National Research Centre For Translational Medicine State Key Laboratory of Medical Genomics, Ruijin Hospital Shanghai Jiatong University School of Medicine  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ji\u2010Guang","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine Shanghai Institute of Hypertension Shanghai Key Laboratory of Hypertension National Research Centre For Translational Medicine State Key Laboratory of Medical Genomics, Ruijin Hospital Shanghai Jiatong University School of Medicine  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,7,25]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehae178"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140\u20106736(88)92867\u2010X"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.124.323515"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/brb3.2530"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41392\u2010024\u201001916\u2010y"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.122.17956"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/jch.12026"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.2147\/TCRM.S116603"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.3109\/10641963.2015.1081230"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen\u20102023\u2010083014"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12882\u2010021\u201002523\u20107"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm12020570"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41371\u2010023\u201000801\u20105"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.3389\/ijph.2023.1605934"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.283.18.2404"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/jch.13543"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1097\/MBP.0b013e3280f813bc"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.7326\/0003\u20104819\u2010150\u20109\u2010200905050\u201000006"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.115.06981"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.122.19996"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.116.004198"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.2337\/diabetes.52.7.1806"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajprenal.00283.2001"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1523\u20101755.2004.00909.x"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms22179221"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1080\/08037051.2021.1996220"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1038\/hr.2016.85"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.122.19372"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12872\u2010020\u201001468\u20103"}],"container-title":["The 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