{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T04:17:24Z","timestamp":1787804244375,"version":"build-2784847793"},"reference-count":20,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2026,8,11]],"date-time":"2026-08-11T00:00:00Z","timestamp":1786406400000},"content-version":"vor","delay-in-days":10,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Clinical Hypertension"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Renal sympathetic denervation (RDN) has demonstrated blood pressure\u2013lowering efficacy in randomized trials; however, long\u2010term real\u2010world data on durability and safety beyond the first year, particularly from the Middle East, remain limited. We conducted a single\u2010center observational cohort study of consecutive patients with resistant hypertension undergoing RDN between February 2023 and December 2025. Baseline blood pressure was defined as the mean of three measurements obtained at separate visits. Follow\u2010up data were collected during routine clinical visits up to 30 months. The primary outcome was durability of blood pressure reduction. Secondary outcomes included changes in antihypertensive medications and renal safety. A total of 105 patients were included. Mean systolic blood pressure decreased from 162.1 \u00b1 18.3\u00a0mmHg at baseline to 142.0 \u00b1 18.9\u00a0mmHg at 12 months (\u221220.1\u00a0mmHg;\n                    <jats:italic>p<\/jats:italic>\n                    &lt; 0.001), with sustained reductions observed through 30 months. Responder rates remained consistently high. Medication escalation was uncommon (6.7%), and most patients had no increase in antihypertensive burden. Renal function remained stable, with no clinically meaningful changes in creatinine or estimated glomerular filtration rate and no major procedure\u2010related complications. In this real\u2010world cohort, RDN was associated with durable blood pressure reduction over 30 months, achieved without systematic medication intensification and with preserved renal safety, supporting its effectiveness in routine clinical practice.\n                  <\/jats:p>","DOI":"10.1111\/jch.70343","type":"journal-article","created":{"date-parts":[[2026,8,11]],"date-time":"2026-08-11T09:49:06Z","timestamp":1786441746000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Durability of Blood Pressure Reduction After Renal Denervation in Resistant Hypertension: Mid\u2010Term Real\u2010World Outcomes From Kuwait"],"prefix":"10.1111","volume":"28","author":[{"given":"Yahya E.","family":"Alansari","sequence":"first","affiliation":[{"name":"Medical Department, College of Medicine Kuwait University  Kuwait City Kuwait"},{"name":"Sabah Al Ahmad Cardiac Center, Amiri Hospital Ministry of Health  Kuwait City Kuwait"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Baha S.","family":"Abed","sequence":"additional","affiliation":[{"name":"Medical Department, College of Medicine Kuwait University  Kuwait City Kuwait"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bara S.","family":"Abed","sequence":"additional","affiliation":[{"name":"Medical Department, College of Medicine Kuwait University  Kuwait City Kuwait"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maryam","family":"Alqouba","sequence":"additional","affiliation":[{"name":"Medical Department, College of Medicine Kuwait University  Kuwait City Kuwait"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abdulwahab","family":"Alsayegh","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Kuwait Institute For Medical Specialization  Kuwait City Kuwait"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abdullah","family":"Alawadi","sequence":"additional","affiliation":[{"name":"Sabah Al Ahmad Cardiac Center, Amiri Hospital Ministry of Health  Kuwait City Kuwait"},{"name":"Department of Internal Medicine Kuwait Institute For Medical Specialization  Kuwait City Kuwait"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Faisal Al","family":"Roomi","sequence":"additional","affiliation":[{"name":"Sabah Al Ahmad Cardiac Center, Amiri Hospital Ministry of Health  Kuwait City Kuwait"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohamed","family":"Mehana","sequence":"additional","affiliation":[{"name":"Sabah Al Ahmad Cardiac Center, Amiri Hospital Ministry of Health  Kuwait City Kuwait"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Budour","family":"Almandeel","sequence":"additional","affiliation":[{"name":"Sabah Al Ahmad Cardiac Center, Amiri Hospital Ministry of Health  Kuwait City Kuwait"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Othman","family":"Alothman","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine McGill University  Montreal Quebec Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nourhan","family":"Elsanadidy","sequence":"additional","affiliation":[{"name":"Medical Department, College of Medicine Kuwait University  Kuwait City Kuwait"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahmad","family":"Tifooni","sequence":"additional","affiliation":[{"name":"Medical Department, College of Medicine Kuwait University  Kuwait City Kuwait"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Khaled F. A. Al","family":"Mula","sequence":"additional","affiliation":[{"name":"Sabah Al Ahmad Cardiac Center, Amiri Hospital Ministry of Health  Kuwait City Kuwait"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,8,11]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehae178"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/HJH.0000000000003480"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIR.0000000000001356"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.111.068064"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1161\/HYP.0000000000000084"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1402670"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140\u20106736(17)32281\u2010X"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140\u20106736(18)30951\u20106"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140\u20106736(18)31082\u20101"},{"key":"e_1_2_9_11_1","first-page":"2476","article-title":"RADIANCE\u2010HTN TRIO Trial","volume":"397","author":"B\u00f6hm M.","year":"2021","journal-title":"Lancet"},{"key":"e_1_2_9_12_1","first-page":"1315","article-title":"European Clinical Consensus on Renal Denervation","volume":"44","author":"Mahfoud F.","year":"2023","journal-title":"European Heart Journal"},{"key":"e_1_2_9_13_1","first-page":"148","article-title":"Durability of Blood Pressure Reduction after Renal Denervation","volume":"79","author":"Kandzari D. E.","year":"2022","journal-title":"Journal of the American College of Cardiology"},{"key":"e_1_2_9_14_1","first-page":"736","article-title":"Renal Denervation: Current Evidence","volume":"78","author":"B\u00f6hm M.","year":"2021","journal-title":"Hypertension"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/cpt.857"},{"key":"e_1_2_9_16_1","first-page":"526","article-title":"Long\u2010Term Efficacy of Renal Denervation","volume":"75","author":"Schmieder R. E.","year":"2020","journal-title":"Hypertension"},{"key":"e_1_2_9_17_1","first-page":"3480","article-title":"Long\u2010Term Effects of Renal Denervation","volume":"43","author":"Kario K.","year":"2022","journal-title":"European Heart Journal"},{"key":"e_1_2_9_18_1","first-page":"1473","article-title":"Renal Denervation in Chronic Kidney Disease","volume":"74","author":"Kiuchi M. G.","year":"2019","journal-title":"Hypertension"},{"key":"e_1_2_9_19_1","first-page":"3319","article-title":"Expert Consensus on Renal Denervation","volume":"38","author":"Mahfoud F.","year":"2017","journal-title":"European Heart Journal"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1097\/HJH.0000000000003650"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1097\/HJH.0000000000000556"}],"container-title":["The Journal of Clinical Hypertension"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jch.70343","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/jch.70343","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jch.70343","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T03:19:03Z","timestamp":1787800743000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jch.70343"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8]]},"references-count":20,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2026,8]]}},"alternative-id":["10.1111\/jch.70343"],"URL":"https:\/\/doi.org\/10.1111\/jch.70343","archive":["Portico"],"relation":{},"ISSN":["1524-6175","1751-7176"],"issn-type":[{"value":"1524-6175","type":"print"},{"value":"1751-7176","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,8]]},"assertion":[{"value":"2026-03-27","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-07-28","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-08-11","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70343"}}