{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T04:17:22Z","timestamp":1787804242375,"version":"build-2784847793"},"reference-count":23,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2026,8,15]],"date-time":"2026-08-15T00:00:00Z","timestamp":1786752000000},"content-version":"vor","delay-in-days":14,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Clinical Hypertension"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Renal artery variations are recognized as potential contributors to hypertension through altered renal perfusion and activation of renin\u2013angiotensin system. However, their clinical and hemodynamic significance in children remains unclear. This retrospective study included 14 pediatric patients (0\u201318 years) with hypertension and renal artery variations. Demographic, laboratory, echocardiographic and ambulatory blood pressure monitoring (ABPM) data were analyzed at baseline and follow\u2010up. Patients were stratified according to serum renin levels (elevated vs. normal). Accessory renal arteries and early branching were identified in 78.4% and 42.8% of patients, respectively. At baseline, 38.4% of patients had left ventricular hypertrophy and most exhibited nocturnal hypertension with impaired dipping patterns. Although daytime, nighttime blood pressure (BP) SDS values tended to decrease during follow\u2010up; 24\u2010h, daytime, nighttime systolic, diastolic BP and mean arterial pressure values did not change significantly in either group. Patients with elevated renin levels showed persistently higher nocturnal BP\u2010SDS values and more pronounced non\u2010dipping patterns. In the high\u2010renin group, left ventricle relative wall thickness (RWT) decreased significantly from 0.41(0.36\u20130.43)\u20130.31(0.27\u20130.35) (\n                    <jats:italic>p\u00a0<\/jats:italic>\n                    =\u00a00.03), whereas left ventricular mass index (LVMI) remained unchanged [33(30\u201340] vs. 37(34\u201345) g\/m\n                    <jats:sup>2<\/jats:sup>\n                    \u00b7\n                    <jats:sup>7<\/jats:sup>\n                    ,\n                    <jats:italic>p\u00a0<\/jats:italic>\n                    =\u00a00.56]. In the normal\u2010renin group, LVMI showed nonsignificant tendency to decrease [34(32\u201355) vs. 30(29\u201351) g\/m\n                    <jats:sup>2<\/jats:sup>\n                    \u00b7\n                    <jats:sup>7<\/jats:sup>\n                    ,\n                    <jats:italic>p\u00a0<\/jats:italic>\n                    =\u00a00.06], while the reduction in RWT did not reach statistical significance (\n                    <jats:italic>p\u00a0<\/jats:italic>\n                    =\u00a00.12). Renal artery variations in children should not be considered purely anatomical findings. Persistent nocturnal hypertension and impaired dipping patterns, particularly in patients with elevated renin levels, may contribute to ongoing target organ damage. Although ABPM parameters remained largely unchanged during follow\u2010up, cardiac remodeling showed distinct patterns according to renin status.\n                  <\/jats:p>","DOI":"10.1111\/jch.70351","type":"journal-article","created":{"date-parts":[[2026,8,16]],"date-time":"2026-08-16T02:44:46Z","timestamp":1786848286000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Ambulatory Blood Pressure Characteristics and Target Organ Effects in Hypertensive Children With Renal Artery Variations"],"prefix":"10.1111","volume":"28","author":[{"given":"Mehmet Baha","family":"Aytac","sequence":"first","affiliation":[{"name":"Department of Pediatric Nephrology Kocaeli University, School of Medicine  Kocaeli Turkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenan","family":"Dogan","sequence":"additional","affiliation":[{"name":"Department of Pediatric Nephrology Kocaeli University, School of Medicine  Kocaeli Turkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Neslihan Dincer","family":"Malkoc","sequence":"additional","affiliation":[{"name":"Department of Pediatric Nephrology Kocaeli University, School of Medicine  Kocaeli Turkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sule Ayas","family":"Ergul","sequence":"additional","affiliation":[{"name":"Department of Pediatric Nephrology Kocaeli University, School of Medicine  Kocaeli Turkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yonca","family":"Anik","sequence":"additional","affiliation":[{"name":"Department of Radiology Kocaeli University, School of Medicine  Kocaeli Turkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mustafa","family":"Dogan","sequence":"additional","affiliation":[{"name":"Department of Pediatric Cardiology Kocaeli University, School of Medicine  Kocaeli Turkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kadir","family":"Babaoglu","sequence":"additional","affiliation":[{"name":"Department of Pediatric Cardiology Kocaeli University, School of Medicine  Kocaeli Turkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenan","family":"Bek","sequence":"additional","affiliation":[{"name":"Department of Pediatric Nephrology Kocaeli University, School of Medicine  Kocaeli Turkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,8,15]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/ca.24255"},{"key":"e_1_2_11_3_1","first-page":"233","article-title":"Anatomic Abnormalities of Cadaver Kidneys Produced for Purposes of Transplantation","volume":"52","author":"Pollak R.","year":"1986","journal-title":"American Surgeon"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1053\/crad.1999.0338"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00276-017-1930-z"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/chd.12608"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/jch.12893"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.4274\/jcrpe.2183"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2008030287"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.2214\/ajr.182.6.1821521"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF01794885"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.echo.2005.10.005"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/0735-1097(92)90385-Z"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9149(99)80200-8"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2017-1904"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1161\/HYP.0000000000000215"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1097\/00004872-200210000-00019"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00467-006-0087-5"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejvs.2013.12.012"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1054\/mehy.2000.1206"},{"key":"e_1_2_11_21_1","first-page":"735","article-title":"Should an Accessory Renal Artery be Considered as a Cause of Hypertension in Adolescents: A Case Report","volume":"62","author":"Moric B. V.","year":"2023","journal-title":"Acta clinica Croatica"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.2169\/internalmedicine.0023-17"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2005.04.042"},{"key":"e_1_2_11_24_1","first-page":"481","article-title":"Accessory Renal Arteries Are Not Related to Hypertension Risk: A Propensity Score\u2010matching Analysis","volume":"41","author":"Liang M.","year":"2025","journal-title":"Acta Cardiologica Sinica"}],"container-title":["The Journal of Clinical Hypertension"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jch.70351","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/jch.70351","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jch.70351","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T03:18:37Z","timestamp":1787800717000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jch.70351"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8]]},"references-count":23,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2026,8]]}},"alternative-id":["10.1111\/jch.70351"],"URL":"https:\/\/doi.org\/10.1111\/jch.70351","archive":["Portico"],"relation":{},"ISSN":["1524-6175","1751-7176"],"issn-type":[{"value":"1524-6175","type":"print"},{"value":"1751-7176","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,8]]},"assertion":[{"value":"2026-05-21","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-08-04","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-08-15","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70351"}}