{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T03:54:51Z","timestamp":1791172491068,"version":"4.1.0"},"reference-count":35,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T00:00:00Z","timestamp":1788480000000},"content-version":"vor","delay-in-days":3,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Clinical Hypertension"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Blood pressure variability (BPV) is an established cardiovascular risk factor associated with target organ damage beyond mean blood pressure levels. Arterial stiffness, assessed by carotid\u2013femoral pulse wave velocity (cfPWV), represents an early manifestation of hypertension and an independent predictor of cardiovascular events. Among short\u2010term BPV indices, Average Real Variability (ARV) is considered a robust marker of blood pressure fluctuations. This study evaluated the relationship between ARV and arterial stiffness and identified clinically relevant ARV thresholds associated with increased cfPWV. A total of 315 adults underwent 24\u2010h ambulatory blood pressure monitoring and cfPWV assessment. Receiver operating characteristic (ROC) analysis was performed to determine optimal systolic and diastolic ARV cut\u2010off values for detecting increased arterial stiffness (cfPWV \u226510 m\/s). Multivariable logistic regression models assessed independent associations between ARV indices and cfPWV. ROC analysis identified daytime systolic ARV \u226511.4\u00a0mmHg as the optimal threshold for predicting cfPWV \u226510 m\/s (AUC 0.68; 95% CI 0.61\u20130.76;\n                    <jats:italic>p<\/jats:italic>\n                    \u00a0&lt;\u00a00.001). Other significant ARV cut\u2010offs ranged between 11.4 and 12.0\u00a0mmHg for systolic and diastolic measures. After adjustment for age, sex, and mean systolic blood pressure, daytime systolic ARV remained independently associated with cfPWV \u226510 m\/s (OR 5.36 95% CI 1.70\u201317.04;\n                    <jats:italic>p<\/jats:italic>\n                    \u00a0&lt;\u00a00.01). All diastolic ARV indices also retained statistical significance, with lower effect sizes (OR 2.45\u20133.25).Daytime systolic ARV \u226511.4\u00a0mmHg shows the strongest independent association with increased arterial stiffness, while diastolic ARV ijch70355ndices remain significant but weaker predictors.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Trial Registration<\/jats:bold>\n                    : The study received approval from the institutional bioethics committee. As it does not meet the criteria for a clinical trial, registration was not applicable.\n                  <\/jats:p>","DOI":"10.1111\/jch.70355","type":"journal-article","created":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T09:50:11Z","timestamp":1788515411000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Average Real Variability Is an Independent Predictor of Increased Arterial Stiffness Assessed by Pulse Wave Velocity"],"prefix":"10.1111","volume":"28","author":[{"ORCID":"https:\/\/orcid.org\/0009-0006-9697-6762","authenticated-orcid":false,"given":"Stanis\u0142aw","family":"Wasiliew","sequence":"first","affiliation":[{"name":"Department of Hypertension, Angiology and Internal Medicine Poznan University of Medical Sciences  Poznan Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dawid","family":"Lipski","sequence":"additional","affiliation":[{"name":"Department of Hypertension, Angiology and Internal Medicine Poznan University of Medical Sciences  Poznan Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ludwina","family":"Chiche\u0142\u2010Szczepaniak","sequence":"additional","affiliation":[{"name":"Department of Hypertension, Angiology and Internal Medicine Poznan University of Medical Sciences  Poznan Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katarzyna","family":"Kostka\u2010Jeziorny","sequence":"additional","affiliation":[{"name":"Department of Hypertension, Angiology and Internal Medicine Poznan University of Medical Sciences  Poznan Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sebastian","family":"\u017burek","sequence":"additional","affiliation":[{"name":"Institute of Physics University of Zielona G\u00f3ra  Zielona G\u00f3ra Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrzej","family":"Tykarski","sequence":"additional","affiliation":[{"name":"Department of Hypertension, Angiology and Internal Medicine Poznan University of Medical Sciences  Poznan Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pawe\u0142","family":"Uruski","sequence":"additional","affiliation":[{"name":"Department of Hypertension, Angiology and Internal Medicine Poznan University of Medical Sciences  Poznan Poland"},{"name":"Greater Poland Center of Digital Medicine Poznan University of Medical Sciences  Poznan 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