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This study examined the associations of common single\u2010nucleotide polymorphisms (SNPs) in key urate transporter genes (\n                    <jats:italic>SLC2A9<\/jats:italic>\n                    ,\n                    <jats:italic>ABCG2<\/jats:italic>\n                    ,\n                    <jats:italic>SLC17A3<\/jats:italic>\n                    ,\n                    <jats:italic>SLC22A7<\/jats:italic>\n                    ,\n                    <jats:italic>SLC22A6<\/jats:italic>\n                    ,\n                    <jats:italic>SLC22A11<\/jats:italic>\n                    ,\n                    <jats:italic>SLC22A12<\/jats:italic>\n                    , and\n                    <jats:italic>ABCC4<\/jats:italic>\n                    ) with salt sensitivity, longitudinal BP changes, and incident hypertension. Data were derived from the Baoji Salt\u2010Sensitivity Study, a family\u2010based cohort in which 514 Chinese adults completed a controlled dietary sodium intervention and were followed prospectively for 14 years. After multivariable adjustment and multiple\u2010testing correction,\n                    <jats:italic>ABCG2<\/jats:italic>\n                    rs2054576 and rs4491984 were associated with DBP response to low\u2010salt diet;\n                    <jats:italic>SLC22A6<\/jats:italic>\n                    rs4149170 with SBP and DBP responses;\n                    <jats:italic>ABCG2<\/jats:italic>\n                    rs12505410\n                    <jats:italic>and SLC22A12<\/jats:italic>\n                    rs7932775 with DBP and MAP responses; and\n                    <jats:italic>ABCC4<\/jats:italic>\n                    rs1189466 and rs17189390 with SBP, DBP, and MAP responses. During high\u2010salt intake,\n                    <jats:italic>SLC2A9<\/jats:italic>\n                    rs3733591 was associated with SBP and MAP responses; and\n                    <jats:italic>SLC22A11<\/jats:italic>\n                    rs3759053,\n                    <jats:italic>ABCC4<\/jats:italic>\n                    rs17189390 and rs9590211 were associated with SBP, DBP, and MAP responses. Over 14 years of follow\u2010up,\n                    <jats:italic>SLC2A9<\/jats:italic>\n                    rs3733591 and\n                    <jats:italic>SLC17A3<\/jats:italic>\n                    rs1165165 were associated with longitudinal systolic BP (SBP) change;\n                    <jats:italic>ABCG2<\/jats:italic>\n                    rs2054576,\n                    <jats:italic>SLC22A7<\/jats:italic>\n                    rs2270860,\n                    <jats:italic>SLC22A12<\/jats:italic>\n                    rs79226484, and\n                    <jats:italic>ABCC4<\/jats:italic>\n                    rs1189466 were associated with diastolic BP (DBP) and MAP change; and\n                    <jats:italic>SLC22A6<\/jats:italic>\n                    rs4149170 and\n                    <jats:italic>ABCC4<\/jats:italic>\n                    rs9590220 and rs7322318 were associated with change in SBP, DBP and MAP. Additionally,\n                    <jats:italic>ABCC4<\/jats:italic>\n                    rs7982809 and rs869951 were associated with incident hypertension over the 14\u2010year follow\u2010up. These findings suggest that genetic variation in urate transporters may contribute to salt sensitivity, long\u2010term BP progression, and hypertension risk, supporting a possible role for urate\u2010transport pathways in BP regulation.\n                  <\/jats:p>","DOI":"10.1111\/jch.70361","type":"journal-article","created":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T03:16:42Z","timestamp":1789528602000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Associations of Genetic Variants in Uric Acid Transporter Genes With Salt Sensitivity, Longitudinal Blood Pressure Changes, and Incident Hypertension in Chinese Adults"],"prefix":"10.1111","volume":"28","author":[{"given":"Ming\u2010Ke","family":"Chang","sequence":"first","affiliation":[{"name":"Department of Cardiology Xi'an No. 1 Hospital, The First Affiliated Hospital of Northwest University  Xi'an China"},{"name":"Department of Cardiovascular Medicine The First Affiliated Hospital of Xi'an Jiaotong University  Xi'an China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ling\u2010Yun","family":"Kong","sequence":"additional","affiliation":[{"name":"Guangdong Key Laboratory of Age\u2010Related Cardiac and Cerebral Diseases Affiliated Hospital of Guangdong Medical University  Zhanjiang Guangdong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhuo\u2010Ran","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology The Affiliated Hospital of Northwest University, Xi'an No. 3 Hospital  Xi'an China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shi","family":"Yao","sequence":"additional","affiliation":[{"name":"Guangdong Key Laboratory of Age\u2010Related Cardiac and Cerebral Diseases Affiliated Hospital of Guangdong Medical University  Zhanjiang Guangdong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Science and Technology The First Affiliated Hospital of Xi'an Jiaotong University  Xi'an China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hao","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Critical Care Medicine The First Affiliated Hospital of Xi'an Jiaotong University  Xi'an China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine The First Affiliated Hospital of Xi'an Jiaotong University  Xi'an China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei\u2010Hua","family":"Gao","sequence":"additional","affiliation":[{"name":"Department of Cardiology Xi'an No. 1 Hospital, The First Affiliated Hospital of Northwest University  Xi'an 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